BMS 833923

ChemicalBook > CAS DataBase List > BMS 833923

Product Name: BMS 833923
CAS No.: 1059734-66-5
Chemical Name: BMS 833923
Synonyms: XL139;CS-944;XL-139;XL 139;BMS 833923;BMS-833923 (XL-139);BMS 833923 USP/EP/BP;BMS 833923; BMS833923; XL-139; XL139; XL 139;N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide;Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-
CBNumber: CB42658184
Molecular Formula: C30H27N5O
Formula Weight: 473.57
MOL File: 1059734-66-5.mol

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BMS 833923 Property

Density: 1.252±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 13.42±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16240
Product name: BMS 833923
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 16240
Product name: BMS 833923
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16240
Product name: BMS 833923
Purity: ≥98%
Packaging: 25mg
Price: $194
Updated: 2024/03/01

Cayman Chemical

Product number: 16240
Product name: BMS 833923
Purity: ≥98%
Packaging: 50mg
Price: $317
Updated: 2024/03/01

TRC

Product number: B596320
Product name: BMS833923
Packaging: 100mg
Price: $395
Updated: 2021/12/16

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BMS 833923 Chemical Properties,Usage,Production

Description

Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC₅₀ = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC₅₀s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.

Uses

BMS 833923 is an antagonist of smoothened, a key hedgehog (Hh) pathway regulator.

BMS 833923 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 833923 Suppliers

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1059734-66-5, BMS 833923Related Search:

XL019 XL147 Y16 TENOVIN-1 LY 303511 (hydrochloride) PFK-015 CCT 137690 CTS-1027 TG101209 BIX 02189 MS436 CNX-1351 Mutant IDH1 inhibitor Glasdegib LDE225 (NVP-LDE225,Erismodegib) Vismodegib (GDC-0449) ABT 737 Sunitinib Malate

BMS 833923

XL 139

XL139

XL-139

BMS-833923 (XL-139)

N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide

Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-

BMS 833923 N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide

N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide BMS-833923

BMS 833923; BMS833923; XL-139; XL139; XL 139

CS-944

BMS 833923 USP/EP/BP

1059734-66-5

Inhibitors