DANSYLCADAVERINE
- Product Name
- DANSYLCADAVERINE
- CAS No.
- 10121-91-2
- Chemical Name
- DANSYLCADAVERINE
- Synonyms
- 5-
- CBNumber
- CB4266400
- Molecular Formula
- C17H25N3O2S
- Formula Weight
- 335.46
- MOL File
- 10121-91-2.mol
DANSYLCADAVERINE Property
- Melting point:
- 137-140 °C
- Boiling point:
- 505.5±60.0 °C(Predicted)
- Density
- 1.190±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Methanol: 10 mg/ml
- form
- powder
- pka
- 11.96±0.50(Predicted)
- color
- Yellow to yellowish green
- Appearance
- Solid Powder
- λmax
- 335 nm
- BRN
- 2951070
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
- Biological Applications
- Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson’s disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington’s disease,spinobulbar atrophy,spinocerebellar ataxia,denta
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 30432
- Product name
- Dansylcadaverine
- Purity
- BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
- Packaging
- 100mg
- Price
- $52
- Updated
- 2025/07/31
- Product number
- 30432
- Product name
- Dansylcadaverine
- Purity
- BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
- Packaging
- 1g
- Price
- $261
- Updated
- 2025/07/31
- Product number
- 15571
- Product name
- Monodansylcadaverine
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 15571
- Product name
- Monodansylcadaverine
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $58
- Updated
- 2024/03/01
- Product number
- D4008
- Product name
- Dansylcadaverine
- Purity
- ≥97% (TLC)
- Packaging
- 100mg
- Price
- $45.6
- Updated
- 2025/07/31
DANSYLCADAVERINE Chemical Properties,Usage,Production
Description
Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.
Uses
Fluorescent substrate for the assay of transamidating enzymes.
Uses
Lysosomotropic fluorescent Probe
Uses
Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells.
Definition
ChEBI: Monodansylcadaverine is a sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. It has a role as a fluorochrome, a protective agent and an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is a sulfonamide, an aminonaphthalene, a tertiary amino compound and a primary amino compound. It is functionally related to a cadaverine.
References
[1] A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation
[2] QI JIANG. Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy.[J]. Journal of Urology, 2012, 188 4: 1361-1368. DOI:10.1016/j.juro.2012.06.004
[3] H T HAIGLER. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.[J]. The Journal of Biological Chemistry, 1980, 255 4: 1239-1241.
[4] S N MURTHY. Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase.[J]. The Journal of Biological Chemistry, 1994, 269 36: 22907-22911.
[5] A NIEMANN H P E A Takatsuki. The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe.[J]. Journal of Histochemistry & Cytochemistry, 2000, 48 2: 251-258. DOI: 10.1177/002215540004800210
[6] A BIEDERBICK H P E H F Kern. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.[J]. European journal of cell biology, 1995, 66 1: 3-14.
DANSYLCADAVERINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DANSYLCADAVERINE manufacturers
- Product
- DANSYLCADAVERINE 10121-91-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03