ChemicalBook > CAS DataBase List > Coumarin 151

Coumarin 151

Product Name
Coumarin 151
CAS No.
53518-15-3
Chemical Name
Coumarin 151
Synonyms
AFC;7-AMINO-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE;7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN;Coumarin 490;AKOS B000459;COUMARIN 151;Coumarine151;BUTTPARK 20\02-79;Coumarin 490. Coumarin 15;7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
CBNumber
CB4277334
Molecular Formula
C10H6F3NO2
Formula Weight
229.16
MOL File
53518-15-3.mol
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Coumarin 151 Property

Melting point:
221-222 °C(lit.)
Boiling point:
314.6±42.0 °C(Predicted)
Density 
1.4096 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
Powder
pka
1.12±0.20(Predicted)
color 
Yellow
Water Solubility 
Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.
λmax
≤207 nm
BRN 
4456797
CAS DataBase Reference
53518-15-3(CAS DataBase Reference)
EPA Substance Registry System
2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)- (53518-15-3)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-37/39
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
248924
Product name
7-Amino-4-(trifluoromethyl)coumarin
Purity
≥99%
Packaging
250mg
Price
$58.42
Updated
2025/07/31
Sigma-Aldrich
Product number
248924
Product name
7-Amino-4-(trifluoromethyl)coumarin
Purity
≥99%
Packaging
1g
Price
$192.85
Updated
2025/07/31
TCI Chemical
Product number
A3747
Product name
7-Amino-4-(trifluoromethyl)coumarin
Purity
min. 97.0 %
Packaging
1G
Price
$88
Updated
2025/07/31
TCI Chemical
Product number
A3747
Product name
7-Amino-4-(trifluoromethyl)coumarin
Purity
min. 97.0 %
Packaging
5G
Price
$264
Updated
2025/07/31
TRC
Product number
A593890
Product name
7-Amino-4-(trifluoromethyl)coumarin
Packaging
250mg
Price
$85
Updated
2021/12/16
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Coumarin 151 Chemical Properties,Usage,Production

Description

Coumarin 490 is a laser dye.

Chemical Properties

Coumarin 151 is yellow powder

Uses

Coumarin 151 is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.

Uses

7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.

Definition

ChEBI: 7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome.

Purification Methods

Purify the coumarin by column chromatography on a C18 column, elute with acetonitrile/0.01M H2O/HCl (1:1), and recrystallise it from isopropanol. Alternatively, it is eluted from a silica gel column with CH2Cl2, or by extracting a CH2Cl2 solution (4g/L) with 1M aqueous NaOH (3 x 0.1L), followed by drying (MgSO4), filtration and evaporation. [Bissell J Org Chem 45 2283 1980, Zimmermann et al. Anal Biochem 70 258 1976.]

Coumarin 151 Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Zinc chloride 3-Aminophenol

Preparation Products

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53518-15-3, Coumarin 151Related Search:

4-Methylcumarin Coumarin ALTRENOGEST Coumarin 120 3-Aminophenol 4-Methylumbelliferone DICUMAROL Glycine 6-Methylcoumarin 3-（trifluoromethyl) Cinnamaldehyde 3-(Trifluoromethyl)benzaldehyde 2-Methylbenzotrifluoride Trifluoromethanesulfonic anhydride N,N-Dimethyl-1,4-phenylenediamine 6-Aminocaproic acid (Trifluoromethyl)trimethylsilane Tris(hydroxymethyl)aminomethane Coumarin-3-carboxylic acid

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