Coumarin 151
- Product Name
- Coumarin 151
- CAS No.
- 53518-15-3
- Chemical Name
- Coumarin 151
- Synonyms
- AFC;7-AMINO-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE;7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN;Coumarin 490;AKOS B000459;COUMARIN 151;Coumarine151;BUTTPARK 20\02-79;Coumarin 490. Coumarin 15;7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
- CBNumber
- CB4277334
- Molecular Formula
- C10H6F3NO2
- Formula Weight
- 229.16
- MOL File
- 53518-15-3.mol
Coumarin 151 Property
- Melting point:
- 221-222 °C(lit.)
- Boiling point:
- 314.6±42.0 °C(Predicted)
- Density
- 1.4096 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.12±0.20(Predicted)
- form
- Powder
- color
- Yellow
- Water Solubility
- Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.
- BRN
- 4456797
- CAS DataBase Reference
- 53518-15-3(CAS DataBase Reference)
- EPA Substance Registry System
- 2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)- (53518-15-3)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- TSCA
- T
- HazardClass
- IRRITANT
- HS Code
- 29322090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 248924
- Product name
- 7-Amino-4-(trifluoromethyl)coumarin
- Purity
- ≥99%
- Packaging
- 250mg
- Price
- $59.4
- Updated
- 2024/03/01
- Product number
- 248924
- Product name
- 7-Amino-4-(trifluoromethyl)coumarin
- Purity
- ≥99%
- Packaging
- 1g
- Price
- $196
- Updated
- 2024/03/01
- Product number
- A18400
- Product name
- 7-Amino-4-(trifluoromethyl)coumarin, 99%
- Packaging
- 0.25g
- Price
- $34.65
- Updated
- 2024/03/01
- Product number
- A18400
- Product name
- 7-Amino-4-(trifluoromethyl)coumarin, 99%
- Packaging
- 1g
- Price
- $110
- Updated
- 2024/03/01
- Product number
- A593890
- Product name
- 7-Amino-4-(trifluoromethyl)coumarin
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
Coumarin 151 Chemical Properties,Usage,Production
Chemical Properties
Coumarin 151 is yellow powder
Uses
Coumarin 151 is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.
Uses
7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.
Definition
ChEBI: 7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome.
Purification Methods
Purify the coumarin by column chromatography on a C18 column, elute with acetonitrile/0.01M H2O/HCl (1:1), and recrystallise it from isopropanol. Alternatively, it is eluted from a silica gel column with CH2Cl2, or by extracting a CH2Cl2 solution (4g/L) with 1M aqueous NaOH (3 x 0.1L), followed by drying (MgSO4), filtration and evaporation. [Bissell J Org Chem 45 2283 1980, Zimmermann et al. Anal Biochem 70 258 1976.]