ChemicalBook > CAS DataBase List > m-Toluidine

m-Toluidine

Product Name
m-Toluidine
CAS No.
108-44-1
Chemical Name
m-Toluidine
Synonyms
META TOLUIDINE;m-Toluidin;3-METHYLANILINE;3-METHYLALANINE;3-Toluidine;3-AMINOTOLUENE;m-Aminotoluene;m-Methylaniline;1-Amino-3-methylbenzene;m-Toludine
CBNumber
CB4277541
Molecular Formula
C7H9N
Formula Weight
107.15
MOL File
108-44-1.mol
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m-Toluidine Property

Melting point:
-30 °C
Boiling point:
203-204 °C(lit.)
Density 
0.999 g/mL at 25 °C(lit.)
vapor pressure 
0.3 hPa (20 °C)
refractive index 
n20/D 1.567(lit.)
Flash point:
186 °F
storage temp. 
Store below +30°C.
solubility 
0.2 g/100 mL (20°C)
pka
4.73(at 25℃)
form 
Crystalline Solid or Liquid
color 
White
Odor
aromatic aniline-like odor
PH
7 (H2O, 20℃)
Water Solubility 
0.2 g/100 mL (20 ºC)
Merck 
14,9536
BRN 
635944
Exposure limits
TLV-TWA skin 2-ppm (～9 mg/m3) (ACGIH).
Dielectric constant
5.9500000000000002
InChIKey
JJYPMNFTHPTTDI-UHFFFAOYSA-N
LogP
1.4 at 25℃
CAS DataBase Reference
108-44-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 3-methyl-(108-44-1)
EPA Substance Registry System
m-Toluidine (108-44-1)
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Safety

Hazard Codes 
T,N
Risk Statements 
45-23/24/25-33-50
Safety Statements 
53-28-36/37-45-61-28A
RIDADR 
UN 1708 6.1/PG 2
WGK Germany 
2
RTECS 
XU2800000
F 
8-23
Autoignition Temperature
>500 °C
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29171990
HS Code 
29214300
Hazardous Substances Data
108-44-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
511218
Product name
m-Toluidine
Purity
99%
Packaging
5ml
Price
$50.82
Updated
2025/07/31
Sigma-Aldrich
Product number
511218
Product name
m-Toluidine
Purity
99%
Packaging
1l
Price
$155.8
Updated
2025/07/31
Sigma-Aldrich
Product number
8.08314
Product name
m-Toluidine
Purity
for synthesis
Packaging
100mL
Price
$36.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08314
Product name
m-Toluidine
Purity
for synthesis
Packaging
1L
Price
$95.6
Updated
2024/03/01
TCI Chemical
Product number
T0298
Product name
m-Toluidine
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$22
Updated
2025/07/31
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m-Toluidine Chemical Properties,Usage,Production

Description

m-Toluidine is an aromatic amine compound widely used as a dye raw material, but the aromatic amines of m-Toluidine and o-anisidine have shown damage to the bladder mucosa and potential carcinogenicity[2]. In addition, m-Toluidine monomers can be synthesized into poly(o-toluidine) by chemical oxidation polymerization in acidic medium, which has anti-corrosion properties for low-carbon steel in 3.5% NaCl[3]. Aniline-m-Toluidine copolymers can also be used to prepare NiO-based multicolor electrochromic films, and the composite films can achieve multiple color changes such as yellow, green, blue and dark brown[4].

Chemical Properties

Colorless liquid. Slightly soluble in water; soluble in alcohol or ether. Combustible.

Uses

Dyes, manufacture of organic chemicals.

Uses

m-Toluidine is an intermediate in the manu facture of dyes and other chemicals.

Uses

m-Toluidine is used in the manufacture of organic chemicals. It is also used in manufacture of various dyes and pigments, photo chemicals, pharmaceutical intermediates.antioxidants, curing agent, accelerator for polymer and rubber industry.

Preparation

m-Toluidine can be obtained by hydrocracking of 2,3-dimethylaniline in the presence of an alkaline nickel-magnesium catalyst.[1]

Synthesis Reference(s)

Synthetic Communications, 11, p. 925, 1981 DOI: 10.1080/00397918108065749

General Description

A clear colorless liquid. Flash point below 200°F. Vapors heavier than air. Toxic by inhalation, ingestion, and skin absorption in high concentrations or under prolonged exposures. Used in the manufacture of organic chemicals. Density about 8 lb / gal.

Reactivity Profile

m-Toluidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Can react vigorously with oxidizing reagents. Emits toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1253].

Health Hazard

Absorption of toxic quantities by any route causes cyanosis (blue discoloroation of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation.

Health Hazard

The toxicity of m-toluidine is similar to thatof o-toluidine. The exposure routes are ingestion, inhalation, and absorption through skin.The toxic effects are methemoglobinemia,anemia, and hematuria. It metabolizes to 2-amino-4-methylphenol, the major componentexcreted in urine. Inhalation of 40-ppm concentration for an hour produced severe poi soning in humans. The oral LD50 value inmice is 740 mg/kg, which is in a range com parable to its o- and p-isomers.
The pure liquid is a mild to moderate skinirritant. Its irritating effect on the eyes ofrabbits was strong.
m-Toluidine did not induce any carcino genicity in test subjects. This finding is incontrast to its ortho-isomer. Nor did it produce any mutagenic activity.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire.

Flammability and Explosibility

Non flammable

Safety Profile

Poison by ingestion and intraperitoneal routes, A skin and eye irritant. Flammable when exposed to heat or flame. Can react vigorously on contact with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx. See also ANILINE and o-TOLUIDINE.

Carcinogenicity

In an 18-month carcinogenicity diet evaluation in maleCD rats (8000 ppm for 3 months, and then 4000 ppm for additional 15 months; or 16,000 ppm for 3 months, and then 8000 for additional 15 months), and male and female CD-1 mice (16,000 ppm for 5 months, and then 4000 ppm in males and 8000 ppm in females for additional 13 months; or 32,000 ppm in both sexes for 5 months, and then 8000 ppm in males and 16,000 ppm in females for additional 13 months), there was no evidence of a significant increase of incidence of any kind of tumor in the rats, and only a significant increase in liver tumors in male mice.

Purification Methods

It can be purified as for aniline. Twice-distilled, m-toluidine is converted to the hydrochloride using a slight excess of HCl, and the salt is fractionally crystallised from 25% EtOH (five times), and from distilled water (twice), rejecting, in each case, the first material that crystallised out. The amine is regenerated and distilled as for o-toluidine. The benzoyl derivative has m 125o (from EtOH). [Berliner & May J Am Chem Soc 49 1007 1927, Beilstein 12 H 853, 12 I 397, 12 II 463, 12 III 1949, 12 IV 1813.]

References

[1] TADASHI MATSUMOTO; Hiroaki T; Y Tachibana. DEMETHYLATION OF 2,3-XYLIDINE TO m-TOLUIDINE[J]. Chemistry Letters, 1978, 7 1: 435-438. DOI:10.1246/CL.1978.435.
[2] TAKESHI TOYODA. Mucosal damage and γ-H2AX formation in the rat urinary bladder induced by aromatic amines with structures similar to o-toluidine and o-anisidine[J]. Archives of Toxicology, 2023, 97 12: 3197-3207. DOI:10.1007/s00204-023-03606-0.
[3] JIAWEI ZHANG; Sensen Z; Ying Li. Preparation, Characterization and Corrosion Evaluation of Poly(o-toluidine), Poly(m-Toluidine), and Poly(p-Toluidine) Blended with Waterborne Polyurethane[J]. JOM, 2018, 70 11: 2660-2666. DOI:10.1007/s11837-018-3122-7.
[4] HONGQIN ZHAO . An efficient multi-color electrochromic electrode based on nanocomposite of aniline and o-toluidine copolymer with nickel oxide[J]. Solar Energy Materials and Solar Cells, 2023, 257: Article 112374. DOI:10.1016/j.solmat.2023.112374.

m-Toluidine Preparation Products And Raw materials

Raw materials

Sodium sulfide nonahydrate 4-Nitrotoluene 3-Nitrotoluene

Preparation Products

1-(3-METHYLPHENYL)PIPERAZINE 5-Methyl-1H-benzotriazole 7-Methylquinoline Reactive Yellow 4 N,N-Diethyl-m-toluidine Solvent Blue 63 hydrogen [4-[[4-(diethylamino)phenyl][4-[ethyl[(3-sulphonatobenzyl)amino]-o-tolyl]methylene]-3-methylcyclohexa-2,5-dien-1-ylidene](ethyl)(3-sulphonatobenzyl)ammonium, sodium salt sodium 3-[[4-(benzoylethylamino)-2-methylphenyl]azo]-4-hydroxynaphthalene-1-sulphonate 3-Chlorotoluene Direct Yellow 86 DIRECT YELLOW 50 3-Fluorotoluene Quinoline-7-carbaldehyde 3-Fluorobenzotrifluoride Reactive Yeiiow M-3RE Solvent Red 25 Phenmedipham Toloxatone 7-Quinolinecarboxylic acid n-benzyl-m-toluidine 4'-BROMO-3'-METHYLACETANILIDE 2-(TRIFLUOROMETHYL)-5-METHYLQUINOLINE-4-CARBOXYLIC ACID N-Ethyl-3-methylaniline
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m-Toluidine Suppliers

Australia 1 Belgium 5 Bulgaria 1 Canada 1 China 256 Czech Republic 1 Europe 2 France 2 Germany 16 India 65 Japan 7 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 19 United States 57 Global 441
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View Lastest Price from m-Toluidine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
m-Toluidine 108-44-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21
Shanghai Xin Cheng Yue Chemical Co.,Ltd
Product
m-Toluidine 108-44-1
Price
US $0.00/kg
Min. Order
10000kg
Purity
99.8%
Supply Ability
100000ton
Release date
2024-01-25
Yixing Wencheng Chemical Co., Ltd
Product
m-Toluidine 108-44-1
Price
US $317.00/KG
Min. Order
5000KG
Purity
99.5% Min
Supply Ability
1000 tons/month
Release date
2025-04-02

108-44-1, m-ToluidineRelated Search:

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