ChemicalBook > CAS DataBase List > ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE

ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE

Product Name: ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE
CAS No.: 26893-12-9
Chemical Name: ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE
Synonyms: BUTTPARK 10\01-32;ethyl 4-oxo-6-(trifluoromethyl)-1H-quinoline-3-carboxylate;ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE;ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE;4-HYDROXY-6-TRIFLUOROMETHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;4-oxo-6-(trifluoromethyl)-1H-quinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 4-hydroxy-6-(trifluoromethyl)-, ethyl ester;3-(Ethoxycarbonyl)-6-(trifluoromethyl)quinolin-4-ol, 3-(Ethoxycarbonyl)-4-hydroxy-6-(trifluoromethyl)quinoline
CBNumber: CB4279909
Molecular Formula: C13H10F3NO3
Formula Weight: 285.22
MOL File: 26893-12-9.mol

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ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE Property

Melting point:: 336(dec.)
Boiling point:: 343.5±37.0 °C(Predicted)
Density: 1.404±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 1.84±0.50(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: E945528
Product name: Ethyl4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 007022
Product name: Ethyl 4-hydroxy-6-(trifluoromethyl)-3-quinolinecarboxylate
Packaging: 1g
Price: $49
Updated: 2021/12/16

Apolloscientific

Product number: PC0654
Product name: Ethyl4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-3-X0
Product name: Ethyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate
Packaging: 1g
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: PC0654
Product name: Ethyl4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate
Packaging: 5g
Price: $195
Updated: 2021/12/16

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ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

49713-39-5

26893-12-9

GENERAL METHODS: Polyphosphoric acid (PPA) (2 eq. by weight) was mixed with Intermediate 1 (40 mmol), followed by the addition of phosphoryl chloride (POCl3) (10 mmol). The reaction mixture was heated to 75 °C and maintained for 8 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was quenched by slowly pouring it into 10% sodium hydroxide solution in an ice bath while adjusting the pH to about 7. The resulting solid was separated by filtration, dried, and washed with ether (3 x 20 mL) to afford ethyl 4-hydroxy-6-trifluoromethylquinoline-3-carboxylate in good yield.

References

[1] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[2] Organic Process Research and Development, 2014, vol. 18, # 11, p. 1482 - 1491
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 6, p. 1577 - 1580

ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

4-Aminobenzotrifluoride Acetic anhydride Triethyl orthoformate Diphenyl ether Diethyl malonate

Preparation Products

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View Lastest Price from ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 26893-12-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: customise
Release date: 2018-08-09

26893-12-9, ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATERelated Search:

METHYL 3-(TRIFLUOROMETHYL)BENZOYLACETATE 3-(3-Trifluoromethylphenyl)propionic acid 4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER 3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 4-HYDROXY-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLIC ACID 3-OXO-3-(3-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER 3'-(TRIFLUOROMETHYL)PROPIOPHENONE 4-HYDROXY-6-METHYLQUINOLINE 2-Methyl-4-(trifluoromethyl) aniline 3'-(Trifluoromethyl)acetophenone 6-(TRIFLUOROMETHYL)QUINOLIN-4-OL 6-(TRIFLUOROMETHYL)QUINOLINE,95% MIN(HPLC) 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE ASISCHEM C52002 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER

BUTTPARK 10\01-32

ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE

ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE

4-HYDROXY-6-TRIFLUOROMETHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

3-(Ethoxycarbonyl)-6-(trifluoromethyl)quinolin-4-ol, 3-(Ethoxycarbonyl)-4-hydroxy-6-(trifluoromethyl)quinoline

4-oxo-6-(trifluoromethyl)-1H-quinoline-3-carboxylic acid ethyl ester

ethyl 4-oxo-6-(trifluoromethyl)-1H-quinoline-3-carboxylate

3-Quinolinecarboxylic acid, 4-hydroxy-6-(trifluoromethyl)-, ethyl ester

26893-12-9

Acids and Derivatives

Heterocycles