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Felodipine

Product Name
Felodipine
CAS No.
72509-76-3
Chemical Name
Felodipine
Synonyms
FEXOFENADINE HCL;Plendil;Felodipin;Agon;modip;Hydac;Spendil;CGH-869;P|endil;h154/82
CBNumber
CB4300661
Molecular Formula
C18H19Cl2NO4
Formula Weight
384.25
MOL File
72509-76-3.mol
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Felodipine Property

Melting point:
142-145°C
Boiling point:
471.5±45.0 °C(Predicted)
Density 
1.3506 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL
form 
solid
pka
2.73±0.70(Predicted)
color 
light yellow
Water Solubility 
insoluble
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC(Cl)=C2Cl)C=1C(OCC)=O
CAS DataBase Reference
72509-76-3(CAS DataBase Reference)
NIST Chemistry Reference
Felodipine(72509-76-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
US7968700
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F9677
Product name
Felodipine
Purity
solid
Packaging
5mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
BP777
Product name
Felodipine
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
BP758
Product name
Felodipine impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
20MG
Price
$251
Updated
2024/03/01
Sigma-Aldrich
Product number
1269389
Product name
Felodipine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
BP758
Product name
Felodipine impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
BP758
Price
$246
Updated
2023/06/20
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Felodipine Chemical Properties,Usage,Production

Description

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

Chemical Properties

White or Light Yellow Crystalline Powder

Originator

Astra (Sweden)

Uses

vasodilator, Ca channel blocker

Uses

Zanarnivir influenza prophylaxis and therapy

Uses

Felodipine is used as a dihydropyridine calcium channel blocker. It displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Definition

ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth m scle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Manufacturing Process

Preparation of 2,3-dichlorobenzylideneacetylacetic acid-methylester.
2,3-Dichlorobenzaldehyde is reacted with methyl acetoacetate in a suitable solvent in the presence of a catalytic amount of acetic acid and piperidine. Water is azeotropically separated off during the reaction. The reaction mixture is extracted in order to remove the catalysts. The solvent is evaporated and methanol is added. The product is crystallized by cooling the solution, isolated by filtration and finally washed with methanol.

brand name

Plendil (AstraZeneca).

Therapeutic Function

Antihypertensive

General Description

Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

Biological Activity

L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Clinical Use

Felodipine is used inthe treatment of angina and mild-to-moderate essential hypertension.Felodipine, like most of the dihydropyridines,exhibits a high degree of protein binding and has a half-liferanging from 10 to 18 hours.

storage

+4°C

References

1) Todd and Faulds, (1992)?Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders; Drugs?44?251 2) Furukawa?et al. (1999)?Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in Xenopus Oocytes; J. Pharmacol. Exp. Ther.?291?464

Felodipine Preparation Products And Raw materials

Raw materials

Preparation Products

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Felodipine Suppliers

Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
Olinax Inc.,
Tel
--
Fax
--
Country
Canada
ProdList
85
Advantage
58
Active Bio Research Inc
Tel
--
Fax
--
Country
Canada
ProdList
5
Advantage
58
Chemtex Pharma Inc.
Tel
--
Fax
--
Email
contact@chemtexpharma.com
Country
Canada
ProdList
163
Advantage
58
Syntech Pharmachem Ltd.
Tel
--
Fax
--
Email
kevinl@syntechpharmachem.com
Country
Canada
ProdList
386
Advantage
58
Apotex Pharmachem Inc.,
Tel
--
Fax
--
Country
Canada
ProdList
44
Advantage
58
Attix Pharmaceuticals/Darmerica
Tel
--
Fax
--
Email
sales@darmerica.com
Country
Canada
ProdList
964
Advantage
58
TLC PharmaChem Inc.
Tel
--
Fax
--
Email
research@tlcpharmachem.com
Country
Canada
ProdList
921
Advantage
60
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View Lastest Price from Felodipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Felodipine 72509-76-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-101%
Supply Ability
500KGS
Release date
2021-06-30
Hebei Weibang Biotechnology Co., Ltd
Product
Felodipine 72509-76-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06
Hebei Yanxi Chemical Co., Ltd.
Product
felodipine 72509-76-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-10

72509-76-3, FelodipineRelated Search:


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