ChemicalBook > CAS DataBase List > Felodipine

Felodipine

Product Name
Felodipine
CAS No.
72509-76-3
Chemical Name
Felodipine
Synonyms
Agon;modip;Hydac;Spendil;CGH-869;P|endil;h154/82;Munobal;Plendil;odipine
CBNumber
CB4300661
Molecular Formula
C18H19Cl2NO4
Formula Weight
384.25
MOL File
72509-76-3.mol
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Felodipine Property

Melting point:
142-145°C
Boiling point:
471.5±45.0 °C(Predicted)
Density 
1.3506 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Store at +4°C
solubility 
DMSO: 28 mg/mL
form 
solid
pka
2.73±0.70(Predicted)
color 
light yellow
Water Solubility 
insoluble
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
CAS DataBase Reference
72509-76-3(CAS DataBase Reference)
NIST Chemistry Reference
Felodipine(72509-76-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
US7968700
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F9677
Product name
Felodipine
Purity
solid
Packaging
5mg
Price
$110
Updated
2021/03/22
Sigma-Aldrich
Product number
F0030000
Product name
Felodipine
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1269389
Product name
Felodipine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$366
Updated
2021/03/22
TCI Chemical
Product number
F0814
Product name
Felodipine
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$101
Updated
2021/03/22
TCI Chemical
Product number
F0814
Product name
Felodipine
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$351
Updated
2021/03/22
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Felodipine Chemical Properties,Usage,Production

Description

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

Chemical Properties

White or Light Yellow Crystalline Powder

Originator

Astra (Sweden)

Uses

vasodilator, Ca channel blocker

Uses

Zanarnivir influenza prophylaxis and therapy

Uses

A dihydropyridine calcium channel blocker

Definition

ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth m scle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Manufacturing Process

Preparation of 2,3-dichlorobenzylideneacetylacetic acid-methylester.
2,3-Dichlorobenzaldehyde is reacted with methyl acetoacetate in a suitable solvent in the presence of a catalytic amount of acetic acid and piperidine. Water is azeotropically separated off during the reaction. The reaction mixture is extracted in order to remove the catalysts. The solvent is evaporated and methanol is added. The product is crystallized by cooling the solution, isolated by filtration and finally washed with methanol.

brand name

Plendil (AstraZeneca).

Therapeutic Function

Antihypertensive

General Description

Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

Biological Activity

L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Clinical Use

Felodipine is used inthe treatment of angina and mild-to-moderate essential hypertension.Felodipine, like most of the dihydropyridines,exhibits a high degree of protein binding and has a half-liferanging from 10 to 18 hours.

Felodipine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Felodipine manufacturers

Hebei Lingding Biological Technology Co., Ltd
Product
Hot selling high quality Felodipine 72509-76-3
Price
US $189.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-04-21
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Felodipine 72509-76-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-101%
Supply Ability
500KGS
Release date
2021-06-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
Felodipine 72509-76-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

72509-76-3, FelodipineRelated Search:


  • ,ethylmethylester
  • ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica
  • 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl ethyl ester
  • Fjodil:Hydac
  • P|endil
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester
  • CGH-869
  • Spendil
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylicacidethylmethylester
  • Felodipine,4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil
  • Felodipine (300 mg)
  • Felodipine (200 mg)
  • Felodipine/Plendil
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester
  • Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Felodipine, USP
  • Felodipine API
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Ethyl Methyl Ester Ethyl Methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • 3-ethyl 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Clevidipine Butyrate iMpurity Ⅱ
  • 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
  • Cleviprex Impurity E
  • Plendil, 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
  • Clevidipine Impurity E
  • h154/82
  • modip
  • FEXOFENADINE HCL
  • 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
  • Felodipin
  • FelodipineUsp25DmfGmp
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil,
  • (RS)-Felodipine
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
  • Agon
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  • Felodipine
  • Plendil
  • Felodipine, 98%, a selective L-type Ca2+ channel blocker
  • Clevidipine Butyrate Impurity 2
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  • Felodipine, ≥98.0%
  • Felodipine CRS
  • Felodipine&gt
  • odipine
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester
  • Hot selling high quality Felodipine
  • Felodipine USP/EP/BP
  • 72509-76-3
  • 72509-76-3;8618
  • C18H19Cl2NO4
  • C18H19NO4Cl2
  • Pharmaceutical material and intermeidates
  • Active Pharmaceutical Ingredients
  • Dihydropyridine Class Chemicals