ChemicalBook > CAS DataBase List > Felodipine

Felodipine

Product Name
Felodipine
CAS No.
72509-76-3
Chemical Name
Felodipine
Synonyms
FEXOFENADINE HCL;Plendil;Felodipin;Agon;modip;Hydac;Spendil;CGH-869;P|endil;h154/82
CBNumber
CB4300661
Molecular Formula
C18H19Cl2NO4
Formula Weight
384.25
MOL File
72509-76-3.mol
More
Less

Felodipine Property

Melting point:
142-145°C
Boiling point:
471.5±45.0 °C(Predicted)
Density 
1.3506 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL
form 
solid
pka
2.73±0.70(Predicted)
color 
light yellow
Water Solubility 
insoluble
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC(Cl)=C2Cl)C=1C(OCC)=O
CAS DataBase Reference
72509-76-3(CAS DataBase Reference)
NIST Chemistry Reference
Felodipine(72509-76-3)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
US7968700
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F9677
Product name
Felodipine
Purity
solid
Packaging
5mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
BP777
Product name
Felodipine
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
BP758
Product name
Felodipine impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
20MG
Price
$251
Updated
2024/03/01
Sigma-Aldrich
Product number
1269389
Product name
Felodipine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
BP758
Product name
Felodipine impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
BP758
Price
$246
Updated
2023/06/20
More
Less

Felodipine Chemical Properties,Usage,Production

Description

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

Chemical Properties

White or Light Yellow Crystalline Powder

Originator

Astra (Sweden)

Uses

vasodilator, Ca channel blocker

Uses

Zanarnivir influenza prophylaxis and therapy

Uses

Felodipine is used as a dihydropyridine calcium channel blocker. It displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Definition

ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth m scle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Manufacturing Process

Preparation of 2,3-dichlorobenzylideneacetylacetic acid-methylester.
2,3-Dichlorobenzaldehyde is reacted with methyl acetoacetate in a suitable solvent in the presence of a catalytic amount of acetic acid and piperidine. Water is azeotropically separated off during the reaction. The reaction mixture is extracted in order to remove the catalysts. The solvent is evaporated and methanol is added. The product is crystallized by cooling the solution, isolated by filtration and finally washed with methanol.

brand name

Plendil (AstraZeneca).

Therapeutic Function

Antihypertensive

General Description

Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

Biological Activity

L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Clinical Use

Felodipine is used inthe treatment of angina and mild-to-moderate essential hypertension.Felodipine, like most of the dihydropyridines,exhibits a high degree of protein binding and has a half-liferanging from 10 to 18 hours.

storage

+4°C

References

1) Todd and Faulds, (1992)?Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders; Drugs?44?251 2) Furukawa?et al. (1999)?Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in Xenopus Oocytes; J. Pharmacol. Exp. Ther.?291?464

Felodipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate Methyl acetoacetate 3-Amino-2-butenoic acid ethyl ester 2,3-Dichlorobenzaldehyde Isopropyl alcohol

Preparation Products

More
Less

Felodipine Suppliers

Americas 1 Austria 1 Belgium 2 Brazil 1 Canada 8 China 353 China Hong Kong 1 Czech Republic 1 Europe 4 Finland 1 France 2 Germany 3 India 48 Japan 2 Malaysia 1 Mexico 1 Nepal 1 Poland 1 Singapore 1 South Korea 2 Spain 2 Switzerland 2 The Netherlands 1 United Arab Emirates 1 United Kingdom 17 United States 51 Global 509
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Laksh Finechem Private Limited
Tel
--
Fax
--
Email
lakshfinechem@yahoo.com
Country
India
ProdList
195
Advantage
58
Maas Pharma Chemicals
Tel
--
Fax
--
Email
info@maaspharmachemicals.com
Country
India
ProdList
1607
Advantage
58
Rivashaa Agrotech Biopharma Pvt. Ltd.
Tel
--
Fax
--
Email
source@rivashaa.com
Country
India
ProdList
986
Advantage
58
AURORE LIFE SCIENCES PRIVATE LIMITED
Tel
--
Fax
--
Email
info@aurorels.com
Country
India
ProdList
42
Advantage
58
Placid Pharmachem
Tel
--
Fax
--
Email
parikshitjain@vsnl.com
Country
India
ProdList
115
Advantage
58
Nivon Specialties (India)
Tel
--
Fax
--
Email
info@nivonindia.com
Country
India
ProdList
154
Advantage
58
NIVEDITA CHEMICALS PVT LTD.
Tel
--
Fax
--
Email
nivechem@gmail.com
Country
India
ProdList
14
Advantage
58
ALEMBIC PHARMACEUTICALS LIMITED
Tel
--
Fax
--
Email
infoal@alembic.co.in
Country
India
ProdList
62
Advantage
58
Sachem
Tel
--
Fax
--
Country
India
ProdList
75
Advantage
58
Oceanic Pharmachem Pvt. Ltd.
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
2005
Advantage
58
Cipla Ltd.
Tel
--
Fax
--
Email
exports@cipla.com
Country
India
ProdList
72
Advantage
58
KPS Chemicals & Pharmaceuticals
Tel
--
Fax
--
Email
kpschempharma@gmail.com
Country
India
ProdList
240
Advantage
58
Esschem Pvt., Ltd.
Tel
--
Fax
--
Email
esschem@vsnl.com
Country
India
ProdList
96
Advantage
58
Vitalchemie Exim Pvt., Ltd.
Tel
--
Fax
--
Email
enquiries@vitalchemie.com
Country
India
ProdList
85
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
Athos Chemicals
Tel
--
Fax
--
Email
export@athoschemicals.com
Country
India
ProdList
315
Advantage
58
Medkem Laboratories
Tel
--
Fax
--
Email
info@medkem.com
Country
India
ProdList
295
Advantage
58
Bridge Chem Pvt., Ltd.
Tel
--
Fax
--
Email
exports@bridgechem.com
Country
India
ProdList
128
Advantage
58
Rawia International HealthCare Pvt. Ltd.
Tel
--
Fax
--
Email
info@rawia.in
Country
India
ProdList
170
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Refsyn Biosciences Pvt., Ltd.
Tel
--
Fax
--
Email
info@refsynbio.com
Country
India
ProdList
226
Advantage
58
Shagun Pharmaceuticals
Tel
--
Fax
--
Email
info@shagunpharma.com
Country
India
ProdList
193
Advantage
58
Emcure Pharmaceuticals Pvt., Ltd.
Tel
--
Fax
--
Email
sachin.ghorpade@emcure.co.in
Country
India
ProdList
18
Advantage
58
Trichem Healthcare Pvt. Ltd.
Tel
--
Fax
--
Email
info@tricheminc.net
Country
India
ProdList
9
Advantage
58
Pharma Chemicals
Tel
--
Fax
--
Country
India
ProdList
130
Advantage
58
Rensun Pharmaceuticals Pvt Ltd.
Tel
--
Fax
--
Email
rensun@mtnl.net.in
Country
India
ProdList
152
Advantage
58
Vyshno Bio Sciences
Tel
--
Fax
--
Email
info@vyshnobio.com
Country
India
ProdList
239
Advantage
58
Prism Consultancy
Tel
--
Fax
--
Email
info@prismconsultancy.biz
Country
India
ProdList
66
Advantage
58
Innorex Pharmaceuticals Private Limited
Tel
--
Fax
--
Email
info@innorexpharma.com
Country
India
ProdList
173
Advantage
58
Orbit Lifescience Pvt., Ltd.
Tel
--
Fax
--
Email
orbit@orbitlifescience.com
Country
India
ProdList
206
Advantage
58
Dazzle Corporation
Tel
--
Fax
--
Email
enquiry@dazzlecorporation.co.in
Country
India
ProdList
209
Advantage
58
Shivam Pharma Chemicals
Tel
--
Fax
--
Email
info@shivampharma.com
Country
India
ProdList
656
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Asara Medi Pharma
Tel
--
Fax
--
Country
India
ProdList
124
Advantage
58
Ebenezer Industries
Tel
--
Fax
--
Email
info@ebenezerindia.in
Country
India
ProdList
53
Advantage
58
Euroasia Trans Continental
Tel
--
Fax
--
Email
eurasia@vsnl.com
Country
India
ProdList
518
Advantage
47
Indogulf Group
Tel
--
Fax
--
Email
info@indogulfgroup.com
Country
India
ProdList
249
Advantage
58
Min Chem India
Tel
--
Fax
--
Country
India
ProdList
6
Advantage
58
Vasudha Pharma Chem Limited
Tel
--
Fax
--
Country
India
ProdList
31
Advantage
58
Life Drug Product
Tel
--
Fax
--
Country
India
ProdList
1
Advantage
58
Lantech Pharmaceuticals Limited
Tel
--
Fax
--
Country
India
ProdList
12
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
OCEAN TRADING CORPORATION
Tel
--
Fax
--
Email
otcchem@otcchem.com
Country
India
ProdList
6202
Advantage
58
More
Less

View Lastest Price from Felodipine manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Felodipine 72509-76-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-06
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Felodipine 72509-76-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-101%
Supply Ability
500KGS
Release date
2021-06-30
Hebei Weibang Biotechnology Co., Ltd
Product
Felodipine 72509-76-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06

72509-76-3, FelodipineRelated Search:

ETHANE Dichlorodimethylsilane Dimethyl phthalate Amlodipine maleate Dimethyl carbonate Amlodipine Dimethyl fumarate N,N-Dimethylformamide Dimethyl sulfoxide Dimethyl sebacate (S)-Amlodipine Dichlorodiphenylsilane Chlorodimethylphenylsilane Amlodipine Besylate Dihydromyrcenol Dimethyl ether Felodipine Metabolite Lactone DEHYDRO FELODIPINE-13C4

  • ,ethylmethylester
  • ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica
  • 4-(2，3-Dichlorophenyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl ethyl ester
  • Fjodil：Hydac
  • P|endil
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester
  • CGH-869
  • Spendil
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylicacidethylmethylester
  • Felodipine,4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil
  • Felodipine (300 mg)
  • Felodipine (200 mg)
  • Felodipine/Plendil
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester
  • Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Felodipine, USP
  • Felodipine API
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Ethyl Methyl Ester Ethyl Methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • 3-ethyl 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Clevidipine Butyrate iMpurity Ⅱ
  • 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
  • Cleviprex Impurity E
  • Plendil, 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
  • Clevidipine Impurity E
  • h154/82
  • modip
  • FEXOFENADINE HCL
  • 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
  • Felodipin
  • FelodipineUsp25DmfGmp
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil,
  • (RS)-Felodipine
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
  • Agon
  • dl-Felodipine
  • Hydac
  • Munobal
  • Splendil
  • Felodipine
  • Plendil
  • Felodipine, 98%, a selective L-type Ca2+ channel blocker
  • Clevidipine Butyrate Impurity 2
  • Felodipine, 98%, Selective L-type Ca2+ channel blocker
  • Felodipine, ≥98.0%
  • Felodipine CRS
  • Felodipine&gt
  • odipine
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester
  • Hot selling high quality Felodipine
  • Felodipine USP/EP/BP
  • Felodipine (CGH869)
  • FelodipineQ: What is Felodipine Q: What is the CAS Number of Felodipine Q: What is the storage condition of Felodipine Q: What are the applications of Felodipine
  • Felodipine (1269389)
  • Felodipine in methanol
  • Felodipine in Acetonitrile
  • Felodipine, 10 mM in DMSO
  • (4R,12aS)-N-(2,3-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide