ChemicalBook > CAS DataBase List > 2-[2-(BENZYLOXY)ETHOXY]ETHANOL

2-[2-(BENZYLOXY)ETHOXY]ETHANOL

Product Name
2-[2-(BENZYLOXY)ETHOXY]ETHANOL
CAS No.
2050-25-1
Chemical Name
2-[2-(BENZYLOXY)ETHOXY]ETHANOL
Synonyms
Bn-PEG2-OH;BnO-PEG2-OH;CAS_2050-25-1;Benzyl-PE2-OH;Benzyl-PEG2-OH;Benzyl-PEG2-alcohol;Benzyl-PEG3-alcohol;2-[2-(BENZYLOXY)ETHOXY]ETHANOL;5-(Benzyloxy)-3-oxapentane-1-ol;DI(ETHYLENE GLYCOL) BENZYL ETHER
CBNumber
CB4301749
Molecular Formula
C11H16O3
Formula Weight
196.24
MOL File
2050-25-1.mol
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2-[2-(BENZYLOXY)ETHOXY]ETHANOL Property

Boiling point:
80-110 °C0.5 mm Hg(lit.)
Density 
1.094 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.51(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
Water Solubility 
Soluble in water
form 
clear liquid
pka
14.36±0.10(Predicted)
color 
Colorless to Almost colorless
Specific Gravity
1.084
InChI
InChI=1S/C11H16O3/c12-6-7-13-8-9-14-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2
InChIKey
LJVNVNLFZQFJHU-UHFFFAOYSA-N
SMILES
C(O)COCCOCC1=CC=CC=C1
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29094990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
499633
Product name
Di(ethylene glycol) benzyl ether
Purity
97%
Packaging
25ml
Price
$133
Updated
2025/07/31
TCI Chemical
Product number
D3408
Product name
Diethylene Glycol Monobenzyl Ether
Purity
>98.0%(GC)
Packaging
25g
Price
$49
Updated
2025/07/31
TCI Chemical
Product number
D3408
Product name
Diethylene Glycol Monobenzyl Ether
Purity
>98.0%(GC)
Packaging
500g
Price
$109
Updated
2025/07/31
TRC
Product number
D446328
Product name
Diethylene Glycol Monobenzyl Ether
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
Y4930
Product name
Diethylene Glycol Monobenzyl Ether
Packaging
100g
Price
$67
Updated
2021/12/16
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2-[2-(BENZYLOXY)ETHOXY]ETHANOL Chemical Properties,Usage,Production

Description

Benzyl-PEG3-alcohol is a PEG linker with an acid labile, benzyl protecting group and a reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Chemical Properties

Colorless to light yellow liquid

Uses

Di(ethylene glycol) benzyl ether may be used as an initiator in the preparation of linear-PLA (poly(L-lactide).

Synthesis

100-44-7

111-46-6

2050-25-1

GENERAL METHOD: Dioxane (15 mL), benzyl chloride (25 mmol) and tetrabutylammonium bromide (0.4 g, 1.2 mmol) were sequentially added to a reaction flask, followed by addition of the mixture to a solution of diethylene glycol (75-125 mmol) containing KOH (1.6 g, 27.5 mmol). The reaction system was heated to 100-105 °C and the reaction was continuously stirred for 5-10 hours. Upon completion of the reaction, the reaction mixture was diluted with CHCl3 (15 mL) and water (10 mL). The organic layer was separated, washed with water (3 x 20 mL) and dried over anhydrous Na2SO4. The organic phase was concentrated under reduced pressure and the residue was purified by distillation through a Vigreux column to afford the target product 2-[2-(phenylmethoxy)ethoxy]ethanol. The specific reaction conditions, yields, physicochemical parameters and 1H NMR data are detailed in Table 6 of the literature.

IC 50

PEGs

References

[1] Synthetic Communications, 1986, vol. 16, # 1, p. 19 - 26
[2] Carbohydrate Research, 1986, vol. 150, p. 199 - 212
[3] Russian Chemical Bulletin, 2014, vol. 63, # 11, p. 2445 - 2454
[4] Izv. Akad. Nauk, Ser. Khim., 2014, # 11, p. 2445 - 2454
[5] Analytical Chemistry, 1992, vol. 64, # 15, p. 1685 - 1690

2-[2-(BENZYLOXY)ETHOXY]ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-(BENZYLOXY)ETHOXY]ETHANOL Suppliers

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View Lastest Price from 2-[2-(BENZYLOXY)ETHOXY]ETHANOL manufacturers

LAURENT
Product
BnO-PEG2-OH 2050-25-1
Price
US $429.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg
Release date
2025-11-20

2050-25-1, 2-[2-(BENZYLOXY)ETHOXY]ETHANOLRelated Search:

Diethylene glycol Diethylene glycol monomethyl ether Diglyme Diethylene Glycol Monoethyl Ether 2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL 2-[2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL Benzyl-PEG2-Amino Benzyl-PEG3-Mes 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL Benzyl-PEG7-amino Benzyl-PEG2-Azide Nonaethylene glycol Monobenzyl ether Benzyl-PEG6-azide Benzyl-PEG8-THP Benzyl-PEG7-alcohol 2,3,4,6-TETRA-O-BENZOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE 2,3,4,6-Tetra-O-benzyl-D-glucopyranose METHYL 4,6-O-BENZYLIDENE-ALPHA-D-GLUCOPYRANOSIDE

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