Benzyl-PEG6-azide

Product Name: Benzyl-PEG6-azide
CAS No.: 86770-73-2
Chemical Name: Benzyl-PEG6-azide
Synonyms: CAS_86770-73-2;Benzyl-PEG6-N3;Benzyl-PEG6-azide;19-Azido-1-phenyl-2,5,8,11,14,17-hexaoxanonadecane;2,5,8,11,14,17-Hexaoxanonadecane, 19-azido-1-phenyl-
CBNumber: CB83048690
Molecular Formula: C19H31N3O6
Formula Weight: 397.47
MOL File: 86770-73-2.mol

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Hazard and Precautionary Statements (GHS)

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Benzyl-PEG6-azide Chemical Properties,Usage,Production

Uses

Benzyl-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Benzyl-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

Benzyl-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Benzyl-PEG6-azide Preparation Products And Raw materials

Raw materials

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Benzyl-PEG6-azide Suppliers

China 24 United States 1 Global 25

Chengdu Pukang Biotechnology Co., Ltd

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View Lastest Price from Benzyl-PEG6-azide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Benzyl-PEG6-N3 86770-73-2
Price: US $0.00/mg
Min. Order: 500mg
Purity: >98.00%
Supply Ability: 500mg
Release date: 2024-03-25

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Benzyl-PEG6-azide

Benzyl-PEG6-N3

CAS_86770-73-2

2,5,8,11,14,17-Hexaoxanonadecane, 19-azido-1-phenyl-

19-Azido-1-phenyl-2,5,8,11,14,17-hexaoxanonadecane

86770-73-2