2-[2-(BENZYLOXY)ETHOXY]ETHANOL
- Product Name
- 2-[2-(BENZYLOXY)ETHOXY]ETHANOL
- CAS No.
- 2050-25-1
- Chemical Name
- 2-[2-(BENZYLOXY)ETHOXY]ETHANOL
- Synonyms
- Bn-PEG2-OH;BnO-PEG2-OH;CAS_2050-25-1;Benzyl-PE2-OH;Benzyl-PEG2-OH;Benzyl-PEG2-alcohol;Benzyl-PEG3-alcohol;2-[2-(BENZYLOXY)ETHOXY]ETHANOL;5-(Benzyloxy)-3-oxapentane-1-ol;DI(ETHYLENE GLYCOL) BENZYL ETHER
- CBNumber
- CB4301749
- Molecular Formula
- C11H16O3
- Formula Weight
- 196.24
- MOL File
- 2050-25-1.mol
2-[2-(BENZYLOXY)ETHOXY]ETHANOL Property
- Boiling point:
- 80-110 °C0.5 mm Hg(lit.)
- Density
- 1.094 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.51(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- form
- clear liquid
- pka
- 14.36±0.10(Predicted)
- color
- Colorless to Almost colorless
- Specific Gravity
- 1.084
- InChI
- InChI=1S/C11H16O3/c12-6-7-13-8-9-14-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2
- InChIKey
- LJVNVNLFZQFJHU-UHFFFAOYSA-N
- SMILES
- C(O)COCCOCC1=CC=CC=C1
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29094990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 499633
- Product name
- Di(ethylene glycol) benzyl ether
- Purity
- 97%
- Packaging
- 25ml
- Price
- $133
- Updated
- 2025/07/31
- Product number
- D3408
- Product name
- Diethylene Glycol Monobenzyl Ether
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- D3408
- Product name
- Diethylene Glycol Monobenzyl Ether
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $109
- Updated
- 2025/07/31
- Product number
- D446328
- Product name
- Diethylene Glycol Monobenzyl Ether
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Y4930
- Product name
- Diethylene Glycol Monobenzyl Ether
- Packaging
- 100g
- Price
- $67
- Updated
- 2021/12/16
2-[2-(BENZYLOXY)ETHOXY]ETHANOL Chemical Properties,Usage,Production
Description
Benzyl-PEG3-alcohol is a PEG linker with an acid labile, benzyl protecting group and a reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Chemical Properties
Colorless to light yellow liquid
Uses
Di(ethylene glycol) benzyl ether may be used as an initiator in the preparation of linear-PLA (poly(L-lactide).
Synthesis
100-44-7
111-46-6
2050-25-1
GENERAL METHOD: Dioxane (15 mL), benzyl chloride (25 mmol) and tetrabutylammonium bromide (0.4 g, 1.2 mmol) were sequentially added to a reaction flask, followed by addition of the mixture to a solution of diethylene glycol (75-125 mmol) containing KOH (1.6 g, 27.5 mmol). The reaction system was heated to 100-105 °C and the reaction was continuously stirred for 5-10 hours. Upon completion of the reaction, the reaction mixture was diluted with CHCl3 (15 mL) and water (10 mL). The organic layer was separated, washed with water (3 x 20 mL) and dried over anhydrous Na2SO4. The organic phase was concentrated under reduced pressure and the residue was purified by distillation through a Vigreux column to afford the target product 2-[2-(phenylmethoxy)ethoxy]ethanol. The specific reaction conditions, yields, physicochemical parameters and 1H NMR data are detailed in Table 6 of the literature.
IC 50
PEGs
References
[1] Synthetic Communications, 1986, vol. 16, # 1, p. 19 - 26
[2] Carbohydrate Research, 1986, vol. 150, p. 199 - 212
[3] Russian Chemical Bulletin, 2014, vol. 63, # 11, p. 2445 - 2454
[4] Izv. Akad. Nauk, Ser. Khim., 2014, # 11, p. 2445 - 2454
[5] Analytical Chemistry, 1992, vol. 64, # 15, p. 1685 - 1690
2-[2-(BENZYLOXY)ETHOXY]ETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-[2-(BENZYLOXY)ETHOXY]ETHANOL manufacturers
- Product
- BnO-PEG2-OH 2050-25-1
- Price
- US $429.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2025-11-20