ChemicalBook > CAS DataBase List > BAY-1163877

BAY-1163877

Product Name: BAY-1163877
CAS No.: 1443530-05-9
Chemical Name: BAY-1163877
Synonyms: Rogaratinib;BAY-1163877;Rogaratinib (BAY1163877);Rogaratinib,inhibit,BAY 1163877,Fibroblast growth factor receptor,BAY-1163877,FGFR,Inhibitor;2-Piperazinone, 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]-;4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-2-one
CBNumber: CB43339855
Molecular Formula: C23H26N6O3S
Formula Weight: 466.56
MOL File: 1443530-05-9.mol

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BAY-1163877 Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:5.0(Max Conc. mg/mL);10.72(Max Conc. mM)
form: Solid
pka: 15.49±0.20(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-8129
Product name: Rogaratinib
Purity: 99.86%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-8129
Product name: Rogaratinib
Purity: 99.86%
Packaging: 5mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-8129
Product name: Rogaratinib
Purity: 99.86%
Packaging: 10mg
Price: $780
Updated: 2021/12/16

ChemScene

Product number: CS-8129
Product name: Rogaratinib
Purity: 99.86%
Packaging: 50mg
Price: $2340
Updated: 2021/12/16

ChemScene

Product number: CS-8129
Product name: Rogaratinib
Purity: 99.86%
Packaging: 100mg
Price: $3540
Updated: 2021/12/16

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BAY-1163877 Chemical Properties,Usage,Production

Uses

Rogaratinib (BAY1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor. Rogaratinib inhibits FGFRs with IC50s of 11.2 nM (FGFR1), <1 nM (FGFR2), 18.5 nM (FGFR3), 127 nM (VEGFR3/FLT4), 201 nM (FGFR4), respectively[1][2].

IC 50

FGFR1; FGFR2; FGFR3; FGFR4

References

[1] Heroult M, et al. Preclinical profile of BAY 1163877-a selective pan-FGFR inhibitor in phase 1 clinical trial[J]. Cancer Res, 2014, 74(suppl 19): 1739a.
[2] Kim SM, et al. Activation of the Met kinase confers acquired drug resistance in FGFR-targeted lung cancer therapy. Oncogenesis. 2016 Jul 18;5(7):e241. DOI:10.1038/oncsis.2016.48

BAY-1163877 Preparation Products And Raw materials

Raw materials

Preparation Products

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1443530-05-9, BAY-1163877Related Search:

BAY1895344 2HCl BAY-2402234 BAY-1125976. BAY-885 BAY-985 BAY 1316957) BAY1895344 HCl BAY-1895344 Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl- BAY 2666605 BAY 2416964

BAY-1163877

Rogaratinib

4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-2-one

Rogaratinib (BAY1163877)

2-Piperazinone, 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]-

Rogaratinib,inhibit,BAY 1163877,Fibroblast growth factor receptor,BAY-1163877,FGFR,Inhibitor

1443530-05-9