ChemicalBook > CAS DataBase List > BAY-1163877
BAY-1163877
- Product Name
- BAY-1163877
- CAS No.
- 1443530-05-9
- Chemical Name
- BAY-1163877
- Synonyms
- Rogaratinib;BAY-1163877;Rogaratinib (BAY1163877);Rogaratinib,inhibit,BAY 1163877,Fibroblast growth factor receptor,BAY-1163877,FGFR,Inhibitor;2-Piperazinone, 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]-;4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-2-one
- CBNumber
- CB43339855
- Molecular Formula
- C23H26N6O3S
- Formula Weight
- 466.56
- MOL File
- 1443530-05-9.mol
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BAY-1163877 Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:5.0(Max Conc. mg/mL);10.72(Max Conc. mM)
- form
- Solid
- pka
- 15.49±0.20(Predicted)
- color
- White to light yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-8129
- Product name
- Rogaratinib
- Purity
- 99.86%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-8129
- Product name
- Rogaratinib
- Purity
- 99.86%
- Packaging
- 5mg
- Price
- $540
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-8129
- Product name
- Rogaratinib
- Purity
- 99.86%
- Packaging
- 10mg
- Price
- $780
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-8129
- Product name
- Rogaratinib
- Purity
- 99.86%
- Packaging
- 50mg
- Price
- $2340
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-8129
- Product name
- Rogaratinib
- Purity
- 99.86%
- Packaging
- 100mg
- Price
- $3540
- Updated
- 2021/12/16
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BAY-1163877 Chemical Properties,Usage,Production
Uses
Rogaratinib (BAY1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor. Rogaratinib inhibits FGFRs with IC50s of 11.2 nM (FGFR1), <1 nM (FGFR2), 18.5 nM (FGFR3), 127 nM (VEGFR3/FLT4), 201 nM (FGFR4), respectively[1][2].
IC 50
FGFR1; FGFR2; FGFR3; FGFR4
References
[1] Heroult M, et al. Preclinical profile of BAY 1163877-a selective pan-FGFR inhibitor in phase 1 clinical trial[J]. Cancer Res, 2014, 74(suppl 19): 1739a.
[2] Kim SM, et al. Activation of the Met kinase confers acquired drug resistance in FGFR-targeted lung cancer therapy. Oncogenesis. 2016 Jul 18;5(7):e241. DOI:10.1038/oncsis.2016.48
BAY-1163877 Preparation Products And Raw materials
Raw materials
Preparation Products
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BAY-1163877 Suppliers
- Tel
- 021-58170097
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- Country
- China
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- Fax
- +86-21-52996696
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- China
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- 021-61350663 13052117465
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- China
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- China
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