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Piperonyl butoxide

Product Name
Piperonyl butoxide
CAS No.
51-03-6
Chemical Name
Piperonyl butoxide
Synonyms
PBO;Butoxide;5-[2-(2-BUTOXYETHOXY)ETHOXYMETHYL]-6-PROPYL-1,3-BENZODIOXOLE;BUTACIDE;Poperonyl butoxide;Piperronyl butoxide;1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-;Vex;INCITE;Butacid
CBNumber
CB4337573
Molecular Formula
C19H30O5
Formula Weight
338.44
MOL File
51-03-6.mol
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Piperonyl butoxide Property

Melting point:
<25 °C
Boiling point:
180 °C
Density 
1.059 g/mL at 25 °C(lit.)
vapor pressure 
0.02 hPa (60 °C)
refractive index 
n20/D 1.498(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
water: slightly soluble0.0289g/L at 20.4°C
form 
Liquid
color 
Clear yellow
Specific Gravity
1.060 (20/4℃)
Odor
mild odor or odorless
Water Solubility 
<0.1 g/100 mL at 18 ºC
Merck 
14,7476
BRN 
288063
Stability:
Stable. Combustible. Incompatible with oxidizing agents.
InChIKey
HHZWGSFIZRNPFB-UHFFFAOYSA-N
LogP
4.750
CAS DataBase Reference
51-03-6(CAS DataBase Reference)
NIST Chemistry Reference
Piperonyl butoxide(51-03-6)
IARC
3 (Vol. 30, Sup 7) 1987
EPA Substance Registry System
Piperonyl butoxide (51-03-6)
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Safety

Hazard Codes 
N,T
Risk Statements 
50/53-51/53-24
Safety Statements 
60-61-45-36/37/39-28A
RIDADR 
UN 3082 9/PG 3
WGK Germany 
3
RTECS 
XS8050000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29329990
Hazardous Substances Data
51-03-6(Hazardous Substances Data)
Toxicity
LD50 orally in female, male rats: 6150, 7500 mg/kg (Gaines)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45626
Product name
Piperonyl Butoxide
Purity
PESTANAL , analytical standard
Packaging
100mg
Price
$63.1
Updated
2024/03/01
Sigma-Aldrich
Product number
291102
Product name
Piperonyl Butoxide
Purity
technical grade, 90%
Packaging
100ml
Price
$74.9
Updated
2024/03/01
Sigma-Aldrich
Product number
BP1171
Product name
Piperonylbutoxide
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
250MG
Price
$228
Updated
2023/01/07
TCI Chemical
Product number
P0458
Product name
Piperonyl Butoxide
Purity
>90.0%(GC)
Packaging
25g
Price
$21
Updated
2024/03/01
TCI Chemical
Product number
P0458
Product name
Piperonyl Butoxide
Purity
>90.0%(GC)
Packaging
500g
Price
$136
Updated
2024/03/01
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Piperonyl butoxide Chemical Properties,Usage,Production

Description

Piperonyl butoxide (PBO) is a water insoluble colorless to pale yellow liquid that was developed in the 1940s to increase the effectiveness of various pesticides. It is currently registered as an active ingredient in more than 1500 products used for indoor or outdoor pesticides, including agricultural maintenance of some food crops.

Chemical Properties

Piperonyl butoxide (PB) is a Light Yellow Liquid. It has no smell or a faint smell and a slightly bitter taste. It does not dissolve in water but can be dissolved in mineral oil and most organic solvents. It is stable to light, resistant to hydrolysis, and is not corrosive. In terms of toxicity, the LD50 (lethal dose for 50% of a test population) is 7500mg/kg in rats when administered orally.

Uses

Piperonyl butoxide is used as a synergist for pyrethrins and their synthetic analogues. It is typically added to carbamate, pyrethrin, pyrethroid, and rotenone pesticides to greatly enhance their potency. PBO alone does not have pesticidal properties.

Preparation

First, safrole is obtained from allyl chloride and methylenedioxybenzene. Then, piperonyl butoxide is produced by catalytic hydrogenation, chloromethylation, and etherification reactions.

Definition

ChEBI: Piperonyl butoxide is a member of benzodioxoles. It has a role as a pesticide synergist.

General Description

Pale yellow to light brown liquid with a mild odor and a faint bitter taste.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Piperonyl butoxide can react with oxidizing materials.

Fire Hazard

Piperonyl butoxide is combustible.

Agricultural Uses

Insecticide synergist: A U.S. EPA restricted Use Pesticide (RUP). Not listed for use in EU countries. Piperonyl butoxide is a synergist, i.e., not a pesticide itself, but enhances the properties of other chemicals. It is used with other pesticides such as pyrethrins, pyrethroids, rotenone and carbamates in food and non-food agricultural products, home and garden products, termite and mosquito products, and veterinary pesticide products. It inhibits the insect’s ability to break down an insecticide before it takes effect, thereby prolonging the action, and reduces the necessity for using a stronger formulation.

Trade name

Trade names have included Butoxide, Butacide, Butocide, and Pyrenone (mixture with allethrin).

Safety Profile

Poison by skin contact. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Many glycol ether compounds have dangerous human reproductive effects, Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomDosition it emits PLATINOL 0 cis-PLATlNUM(II) DIAMMINE- DICHLORIDE

Environmental Fate

PBO is rapidly degraded (half-life 8 h) in the environment by photolysis and is metabolized by soil microorganisms. Its estimated atmospheric half-life is approximately 3 h.

Metabolic pathway

Piperonyl butoxide is used primarily in admixture with pyrethrins and some of the pyrethroids to enhance and prolong their insecticidal action. Much of this use is in domestic and industrial situations. Metabolism studies were conducted soon after its discovery and first use in the 1950s and 1960s. The main impetus initially was to understand the mode of action as a synergist. When this was shown to be due to the inhibition of oxidative metabolism, further studies were conducted to address possible toxic interactions with other pesticides and drugs in man.
Piperonyl butoxide undergoes rapid photodegradation and microbial degradation in soil. It is also rapidly metabolised in insects and mammals by oxidative attack at the methylenedioxy carbon atom and in the side chain. A comprehensive review by Casida (1970) describes the chemistry, mode of action and metabolism of piperonyl butoxide and several related methylenedioxyphenyl compounds. Though published nearly 30 years ago, the review remains a very useful compilation of a large amount of information, supported by more than 300 references.

Degradation

Piperonyl butoxide is stable to hydrolysis at pH 5,7 and 9 in sterile buffers in the dark at 25 °C. It is rapidly degraded in aqueous solution at pH 7 in sunlight with a DT50 of 8.4 hours (PM). The compound was found to be relatively stable under a variety of irradiation conditions as a thin film on glass or in organic solvent (methanol, benzene and cyclohexane). Loss of the butoxyethoxy side chain was observed to give 5-methyl-6-propyl-l,3- benzodioxole (2), butoxyethanol (3) and ethanediol (4) (Fishbein and Gaibel, 1970). These studies did not utilise radiolabelled compound. The partial pathways are shown in Scheme 1.

Toxicity evaluation

Piperonyl butoxide has low to very low toxicity in birds.Researchers consider piperonyl butoxide moderately toxic to fish,although it is unlikely to accumulate.Some aquatic invertebrates may be highly sensitive to this compound.
As a synergist, PBO inhibits mixed-function oxidases, including cytochrome P450, and resistance-associated esterases that allow insects to degrade an insecticide, allowing enhanced insecticide efficacy. It does not effectively act as a synergist in mammals.

Piperonyl butoxide Preparation Products And Raw materials

Raw materials

Preparation Products

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Piperonyl butoxide Suppliers

Wujiang Shuguang Chemical Co.,Ltd
Tel
0512-63682668 13000000000
Fax
86-512-63681308
Email
sales@shuguangchem.com
Country
China
ProdList
1
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
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View Lastest Price from Piperonyl butoxide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Piperonyl butoxide 51-03-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
95%min
Supply Ability
10 tons
Release date
2024-07-19
Watson Biotechnology Co.,Ltd
Product
Piperonyl butoxide 51-03-6
Price
US $0.00-0.00/kg
Min. Order
25kg
Purity
95%
Supply Ability
20MT
Release date
2024-10-25
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Piperonyl butoxide 51-03-6
Price
US $75.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30

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