METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Property

Melting point:

92-94°C

Boiling point:

324.2±32.0 °C(Predicted)

Density 

1.432

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

powder to crystal

color 

White to Light yellow

CAS DataBase Reference

70264-94-7(CAS DataBase Reference)

Safety

Hazard Codes 

Xi,N

Risk Statements 

36/37/38-50/53-43-41-38

Safety Statements 

26-36/37/39-61-60

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

2918999090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Chemical Properties,Usage,Production

Preparation

Methyl 4-(bromomethyl)-3-methoxybenzoate is prepared by the following steps:A mixture of methyl 3-methoxy-4-methylbenzoate 37 (5 g, 27.8 mmol),  NBS (4.94 g, 27.8 mmol), and benoyl peroxide (0.0008 g, 0.003 mmol)  was refluxed in CCl4 (25 ml) for 10 hours. The reaction mixture was  allowed to cool and filtered. The residue was washed with CCl4 and the  combined filtrate concentrated in vacuo. Purification by column  chromatography over silica gel (5-10% EtOAc-pet ether) furnished a colourless solid (7.19  g).Yield : 100%

Uses

Methyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.