2-BROMO-3-METHOXYPYRIDINE

Product Name: 2-BROMO-3-METHOXYPYRIDINE
CAS No.: 24100-18-3
Chemical Name: 2-BROMO-3-METHOXYPYRIDINE
Synonyms: AKOS BBS-00006021;TIMTEC-BB SBB005633;BROMO-3-METHOXYPYRIDINE;2-BROMO-3-METHOXYPYRIDI;2-BROMO-3-METHOXYPYRIDINE;Pyridine,2-bromo-3-methoxy-;2-Bromo-3-methoxypyridine >2-BROMO-3-METHOXYPYRIDINE, 98+%;2-BROMO-3-METHOXYPYRIDINE, PURUM, 97%;2-BROMO-3-METHOXYPYRIDINE ISO 9001：2015 REACH
CBNumber: CB4354149
Molecular Formula: C6H6BrNO
Formula Weight: 188.02
MOL File: 24100-18-3.mol

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2-BROMO-3-METHOXYPYRIDINE Property

Melting point:: 45-49 °C (lit.)
Boiling point:: 233.4±20.0 °C(Predicted)
Density: 1.530±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Dichloromethane
pka: -0.51±0.10(Predicted)
form: Crystalline Powder
color: White to cream
InChI: InChI=1S/C6H6BrNO/c1-9-5-3-2-4-8-6(5)7/h2-4H,1H3
InChIKey: PDOWLYNSFYZIQX-UHFFFAOYSA-N
SMILES: C1(Br)=NC=CC=C1OC
CAS DataBase Reference: 24100-18-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 649716
Product name: 2-Bromo-3-methoxypyridine
Purity: 97%
Packaging: 1g
Price: $31.2
Updated: 2023/06/20

Sigma-Aldrich

Product number: 649716
Product name: 2-Bromo-3-methoxypyridine
Purity: 97%
Packaging: 10g
Price: $278
Updated: 2023/06/20

TCI Chemical

Product number: B3861
Product name: 2-Bromo-3-methoxypyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $92
Updated: 2025/07/31

TCI Chemical

Product number: B3861
Product name: 2-Bromo-3-methoxypyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $327
Updated: 2025/07/31

TRC

Product number: B684820
Product name: 2-Bromo-3-methoxypyridine
Packaging: 250mg
Price: $140
Updated: 2021/12/16

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2-BROMO-3-METHOXYPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

2-BROMO-3-METHOXYPYRIDINE is Light yellow Cryst

Uses

2-BROMO-3-METHOXYPYRIDINE is used in the preparation of triazolopyrimidine derivatives and analogs as AXL receptor tyrosine kinase function inhibitors.

Synthesis Reference(s)

Tetrahedron, 42, p. 1475, 1986 DOI: 10.1016/S0040-4020(01)87367-1

Synthesis

6602-32-0

74-88-4

24100-18-3

Under nitrogen protection, sodium hydride (605 mg, 15.1 mmol) was added in batches to ice-cooled methanol (10 mL). After stirring for 20 min, a solution of 2-bromo-3-hydroxypyridine (2.5 g, 14.4 mmol) in dimethylformamide (20 mL) was added to the reaction system. Subsequently, methanol was removed by distillation under reduced pressure and iodomethane (0.94 mL, 15.1 mmol) was added to the residue. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was concentrated to dryness and the residue was treated with water (50 mL) and ether (50 mL). The organic layer was separated and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic phase was dried with anhydrous magnesium sulfate and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 8:1) to afford the target compound 2-bromo-3-methoxypyridine (1.51 g, 56% yield) as colorless needle-like crystals. The product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 3.90 (3H, s), 7.12 (1H, m), 7.21 (1H, dd, J = 4.8, 8.0 Hz), 7.97 (1H, m). IR (ATR) showed characteristic absorption peaks: 1556, 1410, 1076, 1049, 788 cm-1. The melting point is 34°C.

References

[1] Chemische Berichte, 1983, vol. 116, # 6, p. 2394 - 2397
[2] Patent: EP1466898, 2004, A1. Location in patent: Page 100
[3] Tetrahedron, 1986, vol. 42, # 5, p. 1475 - 1485
[4] Patent: US2003/212110, 2003, A1
[5] Patent: US6166006, 2000, A

2-BROMO-3-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-3-METHOXYPYRIDINE Suppliers

Americas 1 Canada 1 China 196 Europe 1 France 1 Germany 4 India 21 Japan 1 South Korea 1 Sweden 1 Switzerland 1 United Kingdom 7 United States 41 Global 277

Shanghai Kaiwei Chemical Technology Co., Ltd.

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View Lastest Price from 2-BROMO-3-METHOXYPYRIDINE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-BROMO-3-METHOXYPYRIDINE 24100-18-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-BROMO-3-METHOXYPYRIDINE 24100-18-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-05

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2-Bromo-3-methoxypyridine 24100-18-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-04

24100-18-3, 2-BROMO-3-METHOXYPYRIDINERelated Search:

2-Bromo-3-methoxy-6-methylpyridine 2-Bromo-3-ethoxypyridine 6-Bromo-5-methoxypicolinic acid 2-BROMO-3-METHOXYPYRIDINE-4-CARBOXALDEHYDE 2-BROMO-3-(TETRAHYDRO-2-PYRANYLOXY)PYRIDINE 2-BROMO-3-METHOXYPYRIDINE 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile 3-Bromo-5-methoxypyridine CAS:50720-12-2,5-BROMO-3-METHOXYPYRIDINE,3-BROMO-5-METHOXYPYRIDINE 3-Bromo-2-methoxy-5-trifluoromethylpyridine 5-BROMO-2-METHOXYPYRIDINE-3-CARBOXALDEHYDE 5-Bromo-2-Methoxypyridine-3-Bo,5-Bromo-2-methoxypyridine-3-boronic acid 97% 3-Amino-6-bromo-2-methoxypyridine 5-BROMO-2-METHOXYPYRIDINE-3-BORONIC ACID PINACOL ESTER 2-Bromo-6-methoxypyridine ,98%,2-BROMO-6-METHOXYPYRIDINE 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE 5-Bromo-2-methoxypyridine-3-carboxylic acid 3-(5-BROMO-2-METHOXY-PYRIDIN-3-YL)-ACRYLIC ACID ETHYL ESTER 2-Bromo-4-methoxypyridine,bromo-4-methoxypyridine

TIMTEC-BB SBB005633

2-BROMO-3-METHOXYPYRIDINE

AKOS BBS-00006021

2-BROMO-3-METHOXYPYRIDINE, 98+%

2-BROMO-3-METHOXYPYRIDINE, PURUM, 97%

BROMO-3-METHOXYPYRIDINE

Pyridine,2-bromo-3-methoxy-

2-BROMO-3-METHOXYPYRIDI

2-Bromo-3-methoxypyridine &gt

2-BROMO-3-METHOXYPYRIDINE ISO 9001：2015 REACH

24100-18-3

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyridines

Building Blocks

blocks

Bromides

Pyridines

Halides

Pyridine

Heterocyclic Compounds

Heterocycles

C6Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Aromatics