2-BROMO-3-METHOXYPYRIDINE
- Product Name
- 2-BROMO-3-METHOXYPYRIDINE
- CAS No.
- 24100-18-3
- Chemical Name
- 2-BROMO-3-METHOXYPYRIDINE
- Synonyms
- AKOS BBS-00006021;TIMTEC-BB SBB005633;BROMO-3-METHOXYPYRIDINE;2-BROMO-3-METHOXYPYRIDI;2-BROMO-3-METHOXYPYRIDINE;Pyridine,2-bromo-3-methoxy-;2-Bromo-3-methoxypyridine >2-BROMO-3-METHOXYPYRIDINE, 98+%;2-BROMO-3-METHOXYPYRIDINE, PURUM, 97%;2-BROMO-3-METHOXYPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB4354149
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 24100-18-3.mol
2-BROMO-3-METHOXYPYRIDINE Property
- Melting point:
- 45-49 °C (lit.)
- Boiling point:
- 233.4±20.0 °C(Predicted)
- Density
- 1.530±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Dichloromethane
- pka
- -0.51±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to cream
- InChI
- InChI=1S/C6H6BrNO/c1-9-5-3-2-4-8-6(5)7/h2-4H,1H3
- InChIKey
- PDOWLYNSFYZIQX-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=CC=C1OC
- CAS DataBase Reference
- 24100-18-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 649716
- Product name
- 2-Bromo-3-methoxypyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $31.2
- Updated
- 2023/06/20
- Product number
- 649716
- Product name
- 2-Bromo-3-methoxypyridine
- Purity
- 97%
- Packaging
- 10g
- Price
- $278
- Updated
- 2023/06/20
- Product number
- B3861
- Product name
- 2-Bromo-3-methoxypyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- B3861
- Product name
- 2-Bromo-3-methoxypyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $327
- Updated
- 2025/07/31
- Product number
- B684820
- Product name
- 2-Bromo-3-methoxypyridine
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
2-BROMO-3-METHOXYPYRIDINE Chemical Properties,Usage,Production
Chemical Properties
2-BROMO-3-METHOXYPYRIDINE is Light yellow Cryst
Uses
2-BROMO-3-METHOXYPYRIDINE is used in the preparation of triazolopyrimidine derivatives and analogs as AXL receptor tyrosine kinase function inhibitors.
Synthesis Reference(s)
Tetrahedron, 42, p. 1475, 1986 DOI: 10.1016/S0040-4020(01)87367-1
Synthesis
6602-32-0
74-88-4
24100-18-3
Under nitrogen protection, sodium hydride (605 mg, 15.1 mmol) was added in batches to ice-cooled methanol (10 mL). After stirring for 20 min, a solution of 2-bromo-3-hydroxypyridine (2.5 g, 14.4 mmol) in dimethylformamide (20 mL) was added to the reaction system. Subsequently, methanol was removed by distillation under reduced pressure and iodomethane (0.94 mL, 15.1 mmol) was added to the residue. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was concentrated to dryness and the residue was treated with water (50 mL) and ether (50 mL). The organic layer was separated and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic phase was dried with anhydrous magnesium sulfate and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 8:1) to afford the target compound 2-bromo-3-methoxypyridine (1.51 g, 56% yield) as colorless needle-like crystals. The product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 3.90 (3H, s), 7.12 (1H, m), 7.21 (1H, dd, J = 4.8, 8.0 Hz), 7.97 (1H, m). IR (ATR) showed characteristic absorption peaks: 1556, 1410, 1076, 1049, 788 cm-1. The melting point is 34°C.
References
[1] Chemische Berichte, 1983, vol. 116, # 6, p. 2394 - 2397
[2] Patent: EP1466898, 2004, A1. Location in patent: Page 100
[3] Tetrahedron, 1986, vol. 42, # 5, p. 1475 - 1485
[4] Patent: US2003/212110, 2003, A1
[5] Patent: US6166006, 2000, A
2-BROMO-3-METHOXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-BROMO-3-METHOXYPYRIDINE Suppliers
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View Lastest Price from 2-BROMO-3-METHOXYPYRIDINE manufacturers
- Product
- 2-BROMO-3-METHOXYPYRIDINE 24100-18-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 2-BROMO-3-METHOXYPYRIDINE 24100-18-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-05
- Product
- 2-Bromo-3-methoxypyridine 24100-18-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-04