2-Bromopyridine-4-methanol

Product Name: 2-Bromopyridine-4-methanol
CAS No.: 118289-16-0
Chemical Name: 2-Bromopyridine-4-methanol
Synonyms: CAS:118289-16-0;RARECHEM AL BD 1524;Bromopyridine-4-Methanol;2-BROMOPYRIDINE-4-METHANOL;2-Bromopyridine-4-methano1;2-BROMO-4-PYRIDINE METHANOL;(2-bromo-4-pyridyl)methanol;4-Pyridinemethanol, 2-bromo-;2-Bromopyridine-4-methanol ,96%;4-Hydroxymethyl-2-bromopyridine
CBNumber: CB4367567
Molecular Formula: C6H6BrNO
Formula Weight: 188.02
MOL File: 118289-16-0.mol

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2-Bromopyridine-4-methanol Property

Melting point:: 58-61°C
Boiling point:: 316.6±27.0 °C(Predicted)
Density: 1.668±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 13.06±0.10(Predicted)
color: White
BRN: 4244047
InChI: InChI=1S/C6H6BrNO/c7-6-3-5(4-9)1-2-8-6/h1-3,9H,4H2
InChIKey: IQNUGAFIKDRYRP-UHFFFAOYSA-N
SMILES: C1(Br)=NC=CC(CO)=C1
CAS DataBase Reference: 118289-16-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36-37-22
WGK Germany: 1
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 725072
Product name: 2-Bromo-4-hydroxymethylpyridine
Purity: 96%
Packaging: 1g
Price: $64.2
Updated: 2023/06/20

TRC

Product number: B687885
Product name: 2-Bromo-4-hydroxymethylpyridine
Packaging: 500mg
Price: $50
Updated: 2021/12/16

TRC

Product number: B687885
Product name: 2-Bromo-4-hydroxymethylpyridine
Packaging: 10g
Price: $455
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B10424
Product name: 2-Bromo-4-(hydroxymethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $8
Updated: 2021/12/16

Matrix Scientific

Product number: 021365
Product name: 2-Bromo-4-(hydroxymethyl)pyridine
Purity: 97%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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2-Bromopyridine-4-methanol Chemical Properties,Usage,Production

Chemical Properties

2-Bromopyridine-4-methanol is a white to brown powder, it is stable under normal conditions.

Uses

2-Bromo-4-hydroxymethylpyridine is used to synthesize aza- and diazabiphenyl analogs of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824). It is also used to N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine with antiproliferative properties.

Health Hazard

Contact with 2-Bromopyridine-4-methanol causes skin irritation and serious eye irritation.

Synthesis

66572-56-3

118289-16-0

General procedure for the synthesis of 2-bromo-4-pyridinemethanol from 2-bromo-4-pyridinecarboxylic acid: To a solution of tetrahydrofuran (30 mL) containing 2-bromo-4-pyridinecarboxylic acid (2 g, 9.9 mmol, 1.0 eq.) was added drop-wise the boron trifluoride ether compound (4.18 g, 29.7 mmol, 3.0 eq.) at 0 °C. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction mixture was transferred to ice water and the product was extracted with ethyl acetate. The organic layers were combined, washed with brine solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-bromo-4-pyridine methanol (1.4 g, 75.21% yield). Mass spectrum (electrospray): m/z 189.65 [M]+.

References

[1] Patent: WO2018/71794, 2018, A1. Location in patent: Paragraph 00983; 00984
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 18, p. 2866 - 2875
[4] Patent: US2005/54654, 2005, A1. Location in patent: Page/Page column 36
[5] Patent: EP2098517, 2009, A1. Location in patent: Page/Page column 32

2-Bromopyridine-4-methanol Preparation Products And Raw materials

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Preparation Products

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2-Bromopyridine-4-methanol Suppliers

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View Lastest Price from 2-Bromopyridine-4-methanol manufacturers

Hebei Fengjia New Material Co., Ltd

Product: 2-Bromopyridine-4-methanol 118289-16-0
Price: US $30.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100 tons
Release date: 2024-08-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromopyridine-4-methanol 118289-16-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-25

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Bromopyridine-4-methanol 118289-16-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

118289-16-0, 2-Bromopyridine-4-methanolRelated Search:

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2-BROMOPYRIDINE-4-METHANOL

RARECHEM AL BD 1524

Bromopyridine-4-Methanol

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2-Bromopyridine-4-methanol ISO 9001：2015 REACH

(2-bromo-4-pyridyl)methanol

CAS:118289-16-0

2-Bromopyridine-4-methano1

118289-16-0

Heterocycle-Pyridine series

Hydroxymethyl's

Pyridines

Pyridine

Building Blocks