Uses
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YANGONIN

Uses
Product Name
YANGONIN
CAS No.
500-62-9
Chemical Name
YANGONIN
Synonyms
Yan;Y100550;YANGONIN;Yangonin-RM;11-METHOXYYANGONIN;Yangoninpproved, it should be;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-on;Yangonin, 98%, from Piper methysticum Forst;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-one;4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one
CBNumber
CB4393593
Molecular Formula
C15H14O4
Formula Weight
258.27
MOL File
500-62-9.mol
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YANGONIN Property

Melting point:
155-157°
Boiling point:
487.6±45.0 °C(Predicted)
Density 
1.325 g/cm3
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Yellow to Pale Green
BRN 
230710
Stability:
Light Sensitive
LogP
1.750 (est)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
75575
Product name
Yangonin
Purity
analytical standard
Packaging
5MG
Price
$501
Updated
2022/05/15
Cayman Chemical
Product number
14351
Product name
Yangonin
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
14351
Product name
Yangonin
Purity
≥98%
Packaging
5mg
Price
$180
Updated
2024/03/01
Cayman Chemical
Product number
14351
Product name
Yangonin
Purity
≥98%
Packaging
10mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
14351
Product name
Yangonin
Purity
≥98%
Packaging
25mg
Price
$595
Updated
2024/03/01
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YANGONIN Chemical Properties,Usage,Production

Uses

A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.

Description

Yangonin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABAA at 1.0 μM. Yangonin also binds the central cannabinoid (CB1) receptor with a Ki value of 0.72 μM, but whether it serves as an agonist or antagonist at this receptor remains to be determined. Yangonin blocks the activation of NF-κB by TNF-α. It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL).

Uses

A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.

Uses

A lactone isolated from the Kava plant (Piper methysticum). rokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety d isorders. a supplements.

Definition

ChEBI: Yangonin is a member of 2-pyranones and an aromatic ether.

YANGONIN Preparation Products And Raw materials

Raw materials

Preparation Products

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YANGONIN Suppliers

Canada 1 China 125 France 1 Germany 2 India 1 Switzerland 1 United Kingdom 4 United States 20 Global 155
Extrasynthese
Tel
--
Fax
--
Email
info@extrasynthese.com
Country
France
ProdList
1333
Advantage
64
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View Lastest Price from YANGONIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Yangonin 500-62-9
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-02-25
Career Henan Chemical Co
Product
YANGONIN 500-62-9
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

500-62-9, YANGONINRelated Search:

L-KAWAIN FLAVOKAVAIN A(P) DIHYDROMETHYSTICIN Dihydrokawain 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE METHYSTICIN FLAVOKAWAINC Kavain YANGONIN(P),YANGONIN SNAP-N-SHOOT 0.1mg/mL(P) YANGONIN(PRIMARY STANDARD) 2-ACETOXY-1,3-BUTADIENE 4-Methoxy-6-methyl-2H-pyran-2-one DIHYDROKAVAIN DEHYDROMETHYSTICIN YANGONIN

  • YANGONIN
  • 11-METHOXYYANGONIN
  • 4-methoxy-6-(beta-(p-anisyl)vinyl)-alpha-pyrone
  • 4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-on
  • 4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-one
  • 5-hydroxy-3-methoxy-7-(p-methoxyphenyl)-2,4,6-heptatrienoicacidgamma-lacton
  • 4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one
  • 4-Methoxy-6-[(E)-2-(4-methoxyphenyl)vinyl]-2H-pyran-2-one
  • 4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one
  • Yan
  • Yangoninpproved, it should be
  • Yangonin, 98%, from Piper methysticum Forst
  • Y100550
  • (E)-4-Methoxy-6-(4-methoxystyryl)-2H-pyran-2-one
  • 2H-Pyran-2-one, 4-methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]-
  • Yangonin-RM
  • 500-62-9
  • 500-62-0
  • C15H14O4
  • Aromatics
  • Heterocycles
  • Mutagenesis Research Chemicals