GAMMA-SECRETASE INHIBITOR

Product Name: GAMMA-SECRETASE INHIBITOR
CAS No.: 133407-83-7
Chemical Name: GAMMA-SECRETASE INHIBITOR
Synonyms: IN1097;Z-LLNLE-CHO;Z-LEU-LEU-NLE-CHO;Z LLNle CHO,ZLLNleCHO;Z-LEU-LEU-NLE-ALDEHYDE;γ-Secretase Inhibitor I;γ–Secretase Inhibitor I;CBZ-Leu-Leu-Nle-Aldehyde;GAMMA-SECRETASE INHIBITOR;GAMMA-SECRETASE INHIBITOR I
CBNumber: CB4394833
Molecular Formula: C26H41N3O5
Formula Weight: 475.62
MOL File: 133407-83-7.mol

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GAMMA-SECRETASE INHIBITOR Property

storage temp.: −20°C
solubility: DMSO: soluble
form: powder
color: White to off-white
Sensitive: Hygroscopic

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 565750
Product name: γ-Secretase Inhibitor I
Purity: The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
Packaging: 1MG
Price: $176
Updated: 2025/07/31

TRC

Product number: S241008
Product name: γ-SecretaseInhibitorI
Packaging: 10mg
Price: $370
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000969
Product name: GAMMA-SECRETASE INHIBITOR
Purity: 95.00%
Packaging: 1MG
Price: $894.4
Updated: 2021/12/16

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GAMMA-SECRETASE INHIBITOR Chemical Properties,Usage,Production

Uses

gamma-Secretase Inhibitor I is a γ-secretase inhibitor.

Biological Activity

Cell permeable: yes', 'Primary Target
γ-secretase', 'Product does not compete with ATP.', 'Reversible: no

in vivo

Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model^[2].

Animal Model:	Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model)^[2].
Dosage:	5 mg/kg
Administration:	Subcutaneous injection; single daily for 12 days
Result:	Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group.

GAMMA-SECRETASE INHIBITOR Preparation Products And Raw materials

Raw materials

Preparation Products

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GAMMA-SECRETASE INHIBITOR Suppliers

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133407-83-7, GAMMA-SECRETASE INHIBITORRelated Search:

DAPT DIBENZAZEPINE γ-Secretase Inhibitor XXI BETA-SECRETASE INHIBITOR IV N-Cbz-D-glutamic acid alpha-benzyl ester N-Carbobenzyloxy-L-alanine Z-D-ASP(OTBU)-OH H2O Z-NVA-OH Z-PHE-ALA-DIAZOMETHYLKETONE Z-SAR-OH GAMMA-SECRETASE INHIBITOR XVI GAMMA-SECRETASE INHIBITOR XV GAMMA-SECRETASE INHIBITOR XVII GAMMA-SECRETASE INHIBITOR XI GAMMA-SECRETASE INHIBITOR VII GAMMA-SECRETASE INHIBITOR X GAMMA-SECRETASE INHIBITOR XVIII GAMMA-SECRETASE INHIBITOR XIX

Z-LEU-LEU-NLE-ALDEHYDE

Z-LEU-LEU-NLE-CHO

Z-LLNLE-CHO

GAMMA-SECRETASE INHIBITOR

GAMMA-SECRETASE INHIBITOR I

Cbz-leucinyl-leucinyl-norleucinal

γ-Secretase Inhibitor I

L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylpentyl]-

benzyl N-[4-methyl-1-[[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

CBZ-Leu-Leu-Nle-Aldehyde

Z LLNle CHO,ZLLNleCHO

Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxohexan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate

γ–Secretase Inhibitor I

IN1097

133407-83-7

C33H57F2N5O9

Biochemicals and Reagents

BioChemical

R to Z

gamma Secretase

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Alzheimers and Neurodegenerative Disease Research

gamma SecretaseNeurobiology

Neurodegenerative Disease Peptides

Other Alzheimer Peptides

Protease Inhibitor Specificity Index

Protease Inhibitors

R to

γSecretaseEnzyme Inhibitors by Enzyme

OtherNeuropeptides

Z-Leu-Leu-Nle-CHO

Pepetides

peptides