ChemicalBook > CAS DataBase List > APETx2
APETx2
- Product Name
- APETx2
- CAS No.
- 713544-47-9
- Chemical Name
- APETx2
- Synonyms
- APETx2;Cys6-Cys30;Cys20-Cys38);APETx2 USP/EP/BP;APETx2, ASIC3 channel blocker;APETx2, Anthopleura elegantissima, Recombinant, E. coli;H-Gly-Thr-Ala-Cys-Ser-Cys-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys-Arg-Tyr-Phe-Leu-Gly-Thr-Cys-Cys-Thr-Pro-Ala-Asp-OH(Disulfide bridge：Cys4-Cys37;2-[2-[[1-[2-[[52-[2-[[2-[(2-aminoacetyl)amino]-3-hydroxybutanoyl]amino]propanoylamino]-34-(4-aminobutyl)-40-(2-amino-2-oxoethyl)-19,69-dibenzyl-28-butan-2-yl-13,75,96-tris(3-carbamimidamidopropyl)-99-(carboxymethyl)-2~{a},60,87-tris(1-hydroxyethyl)-4,37,49,81-tetrakis(hydroxymethyl)-16,25,72,90-tetrakis[(4-hydroxyphenyl)methyl]-22-(1~{H}-indol-3-ylmethyl)-66-(2-methylpropyl)-1~{a},3,4~{a},6,10~{a},12,15,17~{a},18,21,24,27,30,33,36,39,42,45,48,51,59,62,65,68,71,74,77,80,83,86,89,92,95,98-tetratriacontaoxo-12~{a},13~{a},19~{a},20~{a},54,55-hexathia-~{a},2,3~{a},5,9~{a},11,14,16~{a},17,20,23,26,2
- CBNumber
- CB44673963
- Molecular Formula
- C196H280N54O61S6
- Formula Weight
- 0
- MOL File
- Mol file
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APETx2 Property
- storage temp.
- Store at -20°C
- solubility
- aqueous buffer: soluble
- form
- Powder
- Water Solubility
- Soluble to 5 mg/ml in water
- Sequence
- Gly-Thr-Ala-Cys-Ser-Cys-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys-Arg-Tyr-Phe-Leu-Gly-Thr-Cys-Cys-Thr-Pro-Ala-Asp (Disulfide bridge:Cys4-Cys37;Cys6-Cys30;Cys20-Cys38)
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N-Bromosuccinimide Price
Tocris
- Product number
- 4804
- Product name
- APETx2
- Packaging
- 100U
- Price
- $363
- Updated
- 2021/12/16
Usbiological
- Product number
- 254652
- Product name
- APETx2
- Packaging
- 100ug
- Price
- $644
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B5720
- Product name
- APETx2
- Packaging
- 100ug
- Price
- $528
- Updated
- 2021/12/16
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APETx2 Chemical Properties,Usage,Production
Uses
APETx2 is a highly pure, synthetic and biologically active peptide toxin.
Biological Activity
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible acid-sensing ion channel inhibitor of ASIC3 (acid-sensing ion channel) with IC50 of 63 nM. It acts outside the ASIC3 channel. APETx2 reverses acid-induced inflammatory pain.
in vitro
APETx2 (it or im application, 0.022 to 2.2 μM) resulted in a potent and complete reversal of established mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model.
storage
Store at -20°C
APETx2 Preparation Products And Raw materials
Raw materials
Preparation Products
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