ChemicalBook > CAS DataBase List > 4-THIOURACIL

4-THIOURACIL

Product Name
4-THIOURACIL
CAS No.
591-28-6
Chemical Name
4-THIOURACIL
Synonyms
KC 135;4-thiouracyl;4-THIOURACIL;4-Thiouracil97%;Uracil, 4-thio-;4-Thiouracil 97%;4-Thiouracil ,98%;4-mercaptopyrimidin-2-ol;4-Thioxo-1H-pyrimidin-2-one;2-HYDROXY-4-MERCAPTOPYRIMIDINE
CBNumber
CB4469328
Molecular Formula
C4H4N2OS
Formula Weight
128.15
MOL File
591-28-6.mol
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4-THIOURACIL Property

Melting point:
295 °C (dec.) (lit.)
Density 
1.368 (estimate)
refractive index 
1.7000 (estimate)
storage temp. 
Store at -20°C
solubility 
1 M NaOH: soluble50mg/mL
form 
Powder
pka
5.38±0.20(Predicted)
color 
Yellow
CAS DataBase Reference
591-28-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
440736
Product name
4-Thiouracil
Purity
97%
Packaging
1g
Price
$105
Updated
2024/03/01
TCI Chemical
Product number
T2757
Product name
4-Thiouracil
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$137
Updated
2024/03/01
Alfa Aesar
Product number
H61919
Product name
4-Thiouracil, 97%
Packaging
1g
Price
$80.65
Updated
2024/03/01
Alfa Aesar
Product number
H61919
Product name
4-Thiouracil, 97%
Packaging
250mg
Price
$29.1
Updated
2023/06/20
Cayman Chemical
Product number
16952
Product name
4-Thiouracil
Purity
≥98%
Packaging
1g
Price
$88
Updated
2024/03/01
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4-THIOURACIL Chemical Properties,Usage,Production

Description

4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm. 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.

Chemical Properties

yellow powder

Uses

4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique.

Uses

4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.

Synthesis Reference(s)

Synthesis, p. 256, 1987 DOI: 10.1055/s-1987-27906

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View Lastest Price from 4-THIOURACIL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Thiouracil 591-28-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Career Henan Chemical Co
Product
4-THIOURACIL 591-28-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

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