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4-THIOURACIL

Product Name
4-THIOURACIL
CAS No.
591-28-6
Chemical Name
4-THIOURACIL
Synonyms
KC 135;4-thiouracyl;4-THIOURACIL;4-Thiouracil97%;Uracil, 4-thio-;4-Thiouracil 97%;4-Thiouracil ,98%;4-mercaptopyrimidin-2-ol;4-Thioxo-1H-pyrimidin-2-one;2-HYDROXY-4-MERCAPTOPYRIMIDINE
CBNumber
CB4469328
Molecular Formula
C4H4N2OS
Formula Weight
128.15
MOL File
591-28-6.mol
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4-THIOURACIL Property

Melting point:
295 °C (dec.) (lit.)
Density 
1.368 (estimate)
refractive index 
1.7000 (estimate)
storage temp. 
Store at -20°C
solubility 
1 M NaOH: soluble50mg/mL
form 
Powder
pka
5.38±0.20(Predicted)
color 
Yellow
CAS DataBase Reference
591-28-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
440736
Product name
4-Thiouracil
Purity
97%
Packaging
1g
Price
$105
Updated
2024/03/01
TCI Chemical
Product number
T2757
Product name
4-Thiouracil
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$137
Updated
2024/03/01
Alfa Aesar
Product number
H61919
Product name
4-Thiouracil, 97%
Packaging
1g
Price
$80.65
Updated
2024/03/01
Alfa Aesar
Product number
H61919
Product name
4-Thiouracil, 97%
Packaging
250mg
Price
$29.1
Updated
2023/06/20
Cayman Chemical
Product number
16952
Product name
4-Thiouracil
Purity
≥98%
Packaging
1g
Price
$88
Updated
2024/03/01
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4-THIOURACIL Chemical Properties,Usage,Production

Description

4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm. 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.

Chemical Properties

yellow powder

Uses

4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique.

Uses

4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.

Synthesis Reference(s)

Synthesis, p. 256, 1987 DOI: 10.1055/s-1987-27906

4-THIOURACIL Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethanol Phosphorus oxychloride 2-Thiouracil Benzene Hydrochloric acid Ethylene glycol Acetic acid Sodium hydroxide Sodium hydrosulfide Magnesium sulfate Iodomethane Carbon

Preparation Products

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4-THIOURACIL Suppliers

Belgium 1 China 89 Europe 3 Germany 3 India 4 Japan 1 Slovakia 2 Switzerland 3 United Kingdom 8 United States 21 Global 135
Georganics Ltd.
Tel
--
Fax
--
Email
georganics@nextra.sk
Country
Slovakia
ProdList
613
Advantage
50
MDP ChemControl Ltd.
Tel
--
Fax
--
Email
chemcontrol@nextra.sk
Country
Slovakia
ProdList
6700
Advantage
60
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View Lastest Price from 4-THIOURACIL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Thiouracil 591-28-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Career Henan Chemical Co
Product
4-THIOURACIL 591-28-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

591-28-6, 4-THIOURACILRelated Search:

4-THIOURACIL 6-AZA-2-THIOURACIL 6-PHENYL-2-THIOURACIL,6-Phenyl-2-thiouracil(4-) 6-AMINO-5-NITROSO-2-THIOURACIL AMMONIUM SALT 6-AMINO-2-THIOURACIL HYDRATE,6-AMINO-2-THIOURACIL MONOHYDRATE 5-METHYL-2-THIOURACIL 5-ETHYL-2-THIOURACIL 6-(TRIFLUOROMETHYL)-2-THIOURACIL DITHIOURACIL 6-BENZYL-2-THIOURACIL 6-Thiouracil,Thiouracil,2-THIOURACIL VETRANAL, 250 MG,2-Thiouracil, 98+%,2-THIOURACIL 6-FORMYL-2-THIOURACIL,6-FORMYL-2-THIOURACIL H2O,6-FORMYL-2-THIOURACIL X H2O >95% 6-PROPYL-2-THIOURACIL,6-N-PROPYL-2-THIOURACIL,Propyl-2-thiouracil 5-PROPYL-2-THIOURACIL,3-PROPYL-2-THIOURACIL 6-AMINO-2-THIOURACIL ETHYL 2-THIOURACIL-5-CARBOXYLATE,5-CARBETHOXY-2-THIOURACIL CRYSTALLINE,5-carboethoxy-2-thiouracil 2-Thiouracil, 6-methyl-,4-METHYL-2-THIOURACIL 98%,6-METHYL-2-THIOURACIL,6-METHYL-2-THIOURACIL,REAGENT 5-BROMO-2-METHOXY-4-(METHYLTHIO)PYRIMIDINE

  • 4-Thiouracil97%
  • 4-Thiouracil 97%
  • 2(1H)-Pyrimidinone, 3,4-dihydro-4-thioxo- (9CI)
  • 4-Thiouracil ,98%
  • 4-Thioxo-1H-pyrimidin-2-one
  • 2-HYDROXY-4-MERCAPTOPYRIMIDINE / 4-THIOURACIL
  • 4-thiouracyl
  • 4-sulfanylidene-1,2,3,4-tetrahydropyriMidin-2-one
  • 2-Hydroxy-4-mercaptopyrimidine 3,4-Dihydro-4-thioxo-2(1H)-pyrimidinone
  • 4-thioxo-3,4-dihydropyriMidin-2(1H)-one
  • 4-mercaptopyrimidin-2-ol
  • 2(1H)-Pyrimidinone, 3,4-dihydro-4-thioxo-
  • KC 135
  • Uracil, 4-thio-
  • 4-THIOURACIL
  • 2-HYDROXY-4-MERCAPTOPYRIMIDINE
  • 3,4-Dihydro-4-thioxo-2(1H)-pyrimidinone
  • 4-sulfanylidene-1H-pyrimidin-2-one
  • 2-hydroxypyrimidine-4(3H)-thione
  • 591-28-6
  • C4H4N2OS
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • PYRIMIDINE