ChemicalBook > CAS DataBase List > CC-92480

CC-92480

Product Name
CC-92480
CAS No.
2259648-80-9
Chemical Name
CC-92480
Synonyms
Mezigdomide;Benzonitrile, 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-;CC92489;CC-92480;RSYY（Avanafil)-4;Avanafil Impurity 80;Mezigdomide(CC-92480);CC-92480 ( Mezigdomide );(S)-4-[4-[4-[[[2-(2,6-Dioxo-3-piperidyl)-1-oxo-4-isoindolinyl]oxy]methyl]benzyl]-1-piperazinyl]-3-fluorobenzonitrile;(S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile
CBNumber
CB45821189
Molecular Formula
C32H30FN5O4
Formula Weight
567.61
MOL File
2259648-80-9.mol
More
Less

CC-92480 Property

Boiling point:
833.0±65.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
pka
10.70±0.40(Predicted)
color 
White to off-white
InChIKey
YTINZZFBHWSAGL-NDEPHWFRSA-N
SMILES
C(#N)C1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@H]4CCC(=O)NC4=O)C5=O)C=C3)CC2)C(F)=C1
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0105182
Product name
CC-92480
Purity
98.02%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0105182
Product name
CC-92480
Purity
98.02%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0105182
Product name
CC-92480
Purity
98.02%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0105182
Product name
CC-92480
Purity
98.02%
Packaging
100mg
Price
$2250
Updated
2021/12/16
More
Less

CC-92480 Chemical Properties,Usage,Production

Uses

Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity[1].

References

[1] Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31. DOI:10.1097/PPO.0000000000000354

CC-92480 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CC-92480 Suppliers

China 66 United States 4 Global 70
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

2259648-80-9, CC-92480Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- CC-885 CCT245737 CCF-642 CC-90001 CC-90009 CC-223 CC-90011

  • CC-92480
  • Benzonitrile, 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-
  • CC92489
  • Mezigdomide
  • (S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile
  • RSYY（Avanafil)-4
  • CC 92480,Molecular Glues,Ubiquitin ligase,Ubiquitin activating enzyme,E1/E2/E3 Enzyme,Apoptosis,inhibit,E1 activating enzyme,Mezigdomide,E2 conjugating enzyme,Inhibitor,Ubiquitin conjugating enzyme,CC92480,E3 ligating enzyme
  • Avanafil Impurity 80
  • (S)-4-[4-[4-[[[2-(2,6-Dioxo-3-piperidyl)-1-oxo-4-isoindolinyl]oxy]methyl]benzyl]-1-piperazinyl]-3-fluorobenzonitrile
  • CC-92480 ( Mezigdomide )
  • Mezigdomide(CC-92480)
  • 2259648-80-9
  • C32H30FN5O4