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tert-Butyl 2,6-dichloroisonicotinate

Product Name
tert-Butyl 2,6-dichloroisonicotinate
CAS No.
75308-46-2
Chemical Name
tert-Butyl 2,6-dichloroisonicotinate
Synonyms
TERT-BUTYL 2,6-DICHLOROISONICOTINATE;tert-Butyl 2,6-Dichloroisonicotinate >tert-Butyl 2,6-Dichloroisonicotinate;2,6-Dichloroisonicotinic Acid t-butyl ester;tert-Butyl 2,6-Dichloropyridine-4-carboxylate;tert-Butyl 2,6-dichloro-4-pyridinecarboxylate;2,6-Dichloroisonicotinic acid tert-butyl ester;2,6-dichloro-4-pyridinecarboxylic acid tert-butyl ester;2,6-dichloro-4-pyridinecarboxylic acid 1,1-dimethylethyl ester;4-Pyridinecarboxylic acid, 2,6-dichloro-, 1,1-dimethylethyl ester
CBNumber
CB4669250
Molecular Formula
C10H11Cl2NO2
Formula Weight
248.11
MOL File
75308-46-2.mol
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tert-Butyl 2,6-dichloroisonicotinate Property

Melting point:
80.0 to 84.0 °C
Boiling point:
326°C
Density 
1.278
Flash point:
151°C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
-4.43±0.10(Predicted)
color 
White to Light yellow to Light orange
CAS DataBase Reference
75308-46-2(CAS DataBase Reference)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3595
Product name
tert-Butyl 2,6-Dichloroisonicotinate
Purity
>98.0%(GC)
Packaging
5g
Price
$157
Updated
2025/07/31
TRC
Product number
B903155
Product name
tert-Butyl 2,6-Dichloroisonicotinate
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B903155
Product name
tert-Butyl 2,6-Dichloroisonicotinate
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
1699AC
Product name
tert-Butyl 2,6-Dichloroisonicotinate
Packaging
250mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB149300
Product name
tert-Butyl 2,6-Dichloroisonicotinate
Packaging
250mg
Price
$57.5
Updated
2021/12/16
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tert-Butyl 2,6-dichloroisonicotinate Chemical Properties,Usage,Production

Synthesis

To a solution of 2,6-dichloroisonicotinic acid (2 g, 10.4 mmol) in toluene (50 mL) N, N- dimethylformamide di-fert-butil acetal (15 mL, 62.5 mmol) was added under nitrogen atmosphere and mixture heated at 80°C overnight. Ethyl acetate was added, and the organic layer was washed with water and brine, dried (MgS04), filtered and concentrated to yield tert-Butyl 2,6-dichloroisonicotinate (2.34 g, 87 per cent) as a solid.

References

[1] Patent: WO2008/11499, 2008, A1. Location in patent: Page/Page column 37-38
[2] Organic Process Research and Development, 2009, vol. 13, # 6, p. 1145 - 1155
[3] Patent: WO2010/111058, 2010, A1. Location in patent: Page/Page column 79

tert-Butyl 2,6-dichloroisonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 2,6-dichloroisonicotinate Suppliers

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View Lastest Price from tert-Butyl 2,6-dichloroisonicotinate manufacturers

Career Henan Chemical Co
Product
tert-Butyl 2,6-dichloroisonicotinate 75308-46-2
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

75308-46-2, tert-Butyl 2,6-dichloroisonicotinateRelated Search:

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  • 2,6-Dichloroisonicotinic acid tert-butyl ester
  • 2,6-Dichloroisonicotinic Acid t-butyl ester
  • <i>tert</i>-Butyl 2,6-Dichloroisonicotinate
  • tert-Butyl 2,6-Dichloropyridine-4-carboxylate
  • 2,6-Dichloroisonicotinic Acid tert-Butyl Ester tert-Butyl 2,6-Dichloro-4-pyridinecarboxylate 2,6-Dichloro-4-pyridinecarboxylic Acid tert-Butyl Ester
  • 2,6-dichloro-4-pyridinecarboxylic acid tert-butyl ester
  • tert-Butyl 2,6-Dichloroisonicotinate &gt
  • 4-Pyridinecarboxylic acid, 2,6-dichloro-, 1,1-dimethylethyl ester
  • 75308-46-2