3'-Fluoro-4'-hydroxyacetophenone
- Product Name
- 3'-Fluoro-4'-hydroxyacetophenone
- CAS No.
- 403-14-5
- Chemical Name
- 3'-Fluoro-4'-hydroxyacetophenone
- Synonyms
- BUTTPARK 153\33-64;3-FLUORO-4-HYDROXYACETOPHENONE;3'-Fluoro-4'-hydroxyacetophenone;3'-Fluoro-4'-hydroxyacetophenone>1-(3-FLUORO-4-HYDROXYPHENYL)ETHANONE;3'-Fluoro-4'-hydroxyacetophenone, 98+%;Ethanone, 1-(3-fluoro-4-hydroxyphenyl)-;1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE;1-(3-fluoro-4-hydroxyphenyl)ethan-1-one;1-(3-fluoro-4-hydroxyphenyl)-1-ethanone (en)
- CBNumber
- CB4675321
- Molecular Formula
- C8H7FO2
- Formula Weight
- 154.14
- MOL File
- 403-14-5.mol
3'-Fluoro-4'-hydroxyacetophenone Property
- Melting point:
- 127-129°C
- Boiling point:
- 125-135 °C(Press: 2 Torr)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 6.91±0.18(Predicted)
- color
- Light yellow to Yellow to Orange
- BRN
- 1936529
- InChIKey
- GSWTXZXGONEVJC-UHFFFAOYSA-N
- CAS DataBase Reference
- 403-14-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS002790
- Product name
- 3′-Fluoro-4′-hydroxyacetophenone
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- F0843
- Product name
- 3'-Fluoro-4'-hydroxyacetophenone
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- F0843
- Product name
- 3'-Fluoro-4'-hydroxyacetophenone
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $235
- Updated
- 2025/07/31
- Product number
- F597378
- Product name
- 3''-Fluoro-4''-hydroxyacetophenone
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F597378
- Product name
- 3''-Fluoro-4''-hydroxyacetophenone
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
3'-Fluoro-4'-hydroxyacetophenone Chemical Properties,Usage,Production
Uses
3''-Fluoro-4''-hydroxyacetophenone
Preparation
Preparation by reaction of pyridinium chloride on 3-fluoro-4- methoxyacetophenone at reflux (78%).
Synthesis
29650-44-0
367-12-4
403-14-5
699-92-3
The mixture was heated to 120 °C with 2-fluorophenyl acetate (3,1.070 kg, 6.94 mol) and monochlorobenzene (5.34 L). Aluminum trichloride (1.39 kg, 10.42 mol) was added in batches over a period of 70-75 min at 120 °C, increasing the temperature by about 5 °C by controlling the rate of addition. The reaction was continued at the same temperature for 3 hours. Subsequently, the reaction mixture was cooled to 0-5 °C. Water (1.07 L) and 3.5% hydrochloric acid (2.14 L) were added sequentially under vigorous stirring using an ice bath to keep the internal temperature below 30 °C. The mixture was stirred vigorously at 5-10 °C for 1 h and then filtered, the solid filter cake was washed with water (1 L) and dried to give a beige solid, i.e., para-isomer 4 (416 g, 38.8% yield, HPLC purity >98%). The organic layer was separated from the filtrate and the organic layer was washed with water (2 L) and concentrated at atmospheric pressure to give the crude product (530 g), which was subsequently purified by steam distillation. The first part of the steam distillation was a liquid rich in 2-fluorophenol (45.2 g, LC analysis showed 70% 2-fluorophenol, 4% 4, 21% 5), and the second part was a light yellow solid, i.e., the neighboring isomer 5. The product 5 was separated by filtration, washed with water (80 mL), and then dried under vacuum to give the title compound (257.6 g, yield 24%, HPLC purity > 98.2%) as a light yellow solid. Steam distillation of the residue (HPLC analysis showed 92.7% 4, 3.63% 5) was crystallized by MTBE:hexane to give compound 4 (205.4 g, 19.2% yield, HPLC purity >98%).1H NMR (CDCl3, 400 MHz) data for 3-fluoro-4-hydroxyacetophenone (4): δ 7.75-7.67 (m, 2H, ArH), 7.06 (t, 1H, J = 8.4 Hz, ArH), 5.98 (d, 1H, J = 4 Hz, Ar-OH), 2.56 (s, 3H, Ac). m/z 153.00 was observed by LCMS. 1H NMR (CDCl3, 400 MHz) data of 3-fluoro-2-hydroxyacetophenone (5): δ 12.29 (s, 1H OH), 7.56-7.51 (m, 1H, ArH), 7.32-7.25 (m, 1H, ArH), 6.88-6.81 (m, 1H, ArH), 2.66 (s, 3H, CH3). m/z 153.00 observed by LCMS.
References
[1] Tetrahedron Letters, 2014, vol. 55, # 15, p. 2426 - 2429
3'-Fluoro-4'-hydroxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
3'-Fluoro-4'-hydroxyacetophenone Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 3'-Fluoro-4'-hydroxyacetophenone manufacturers
- Product
- 3'-Fluoro-4'-hydroxyacetophenone 403-14-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06
- Product
- 3'-Fluoro-4'-hydroxyacetophenone 403-14-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-08
- Product
- 3'-Fluoro-4'-hydroxyacetophenone 403-14-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.3%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20