ChemicalBook > CAS DataBase List > 2-Fluoro-6-methoxybenzaldehyde

2-Fluoro-6-methoxybenzaldehyde

Product Name: 2-Fluoro-6-methoxybenzaldehyde
CAS No.: 146137-74-8
Chemical Name: 2-Fluoro-6-methoxybenzaldehyde
Synonyms: RARECHEM AK VD 0022;5-Isobutylacetophenone;6-FLUORO-O-ANISALDEHYDE;2-Fluoro-6-mehoxybenzaldehyde;2-METHOXY-6-FLUOROBENZALDEHYDE;2-FLUORO-6-METHOXYBENZALDEHYDE;2-Fluoro-6-methoxybenzaldenyde;2-Fluoro-6-methoxybenzaldehyde99%;Benzaldehyde, 2-fluoro-6-methoxy-;2-Fluoro-6-methoxybenzaldehyde 99%
CBNumber: CB4683092
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 146137-74-8.mol

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2-Fluoro-6-methoxybenzaldehyde Property

Melting point:: 59-63 °C (lit.)
Boiling point:: 218.5±20.0 °C(Predicted)
Density: 0.807 g/mL at 25 °C
refractive index: n20/D 1.339
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: 5 wt.% in methanol
color: White to tan
Sensitive: Air Sensitive
CAS DataBase Reference: 146137-74-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: UN 1230 3/PG 2
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 536733
Product name: 2-Fluoro-6-methoxybenzaldehyde
Purity: 98%
Packaging: 1g
Price: $36
Updated: 2023/06/20

Sigma-Aldrich

Product number: 536733
Product name: 2-Fluoro-6-methoxybenzaldehyde
Purity: 98%
Packaging: 5g
Price: $53.2
Updated: 2023/06/20

TCI Chemical

Product number: F1175
Product name: 6-Fluoro-o-anisaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: F1175
Product name: 6-Fluoro-o-anisaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $134
Updated: 2025/07/31

TRC

Product number: F401495
Product name: 2-Fluoro-6-methoxybenzaldehyde
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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2-Fluoro-6-methoxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

off-white crystalline

Synthesis

456-49-5

68-12-2

146137-74-8

General procedure for the synthesis of 2-fluoro-6-methoxybenzaldehyde from m-fluoroanisole and N,N-dimethylformamide: n-butyllithium (1.6 M in hexane, 74.3 ml, 0.118 mol) was added slowly and dropwise to a solution of diisopropylamine (13.23 g, 0.130 mol) in tetrahydrofuran (50 ml) at 0 °C. After maintaining this temperature for 15 min, the reaction system was cooled to -78°C. Subsequently, a tetrahydrofuran (5 ml) solution of 3-fluoroanisole (15 g, 0.118 mol) was added and stirred at -78 °C for 1 hour. Next, N,N-dimethylformamide (6.75 ml) was added and stirring was continued at the same temperature for 1 hour. After completion of the reaction, the reaction was burst with 2N hydrochloric acid solution followed by extraction with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 2-fluoro-6-methoxybenzaldehyde as a red waxy solid (17.45 g, 95% yield), which could be used in subsequent steps without further purification.

References

[1] Patent: US2012/289496, 2012, A1. Location in patent: Page/Page column 100
[2] Chemistry - A European Journal, 2015, vol. 21, # 29, p. 10322 - 10325
[3] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7499 - 7502
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 12, p. 2998 - 3001
[5] Patent: WO2012/151525, 2012, A1. Location in patent: Page/Page column 100; 101

2-Fluoro-6-methoxybenzaldehyde Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 3-Fluoroanisole Tetrahydrofuran Ethyl acetate n-Butyllithium

Preparation Products

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View Lastest Price from 2-Fluoro-6-methoxybenzaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Fluoro-6-methoxybenzaldehyde 146137-74-8
Price: US $0.00-0.00/g
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Career Henan Chemical Co

Product: 2-Fluoro-6-methoxybenzaldehyde 146137-74-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 90%-99.9%
Supply Ability: 1000kg
Release date: 2019-07-04

146137-74-8, 2-Fluoro-6-methoxybenzaldehydeRelated Search:

2,4-Dimethoxybenzaldehyde 2,3-Dimethoxybenzaldehyde 2,6-Dimethoxybenzaldehyde 3-Methoxybenzaldehyde Anisole (Trifluoromethoxy)benzene Veratraldehyde 4-Dimethylaminobenzaldehyde 3-(Trifluoromethyl)benzaldehyde p-Anisaldehyde Benzaldehyde 4-(Trifluoromethyl)benzaldehyde 4-Hydroxybenzaldehyde 4-(Trifluoromethoxy)aniline 2,5-Dimethoxybenzaldehyde 3,5-Dimethoxybenzaldehyde Fluorine 2'-FLUORO-6'-METHOXYACETOPHENONE

RARECHEM AK VD 0022

2-FLUORO-6-METHOXYBENZALDEHYDE

2-METHOXY-6-FLUOROBENZALDEHYDE

6-FLUORO-O-ANISALDEHYDE

2-Fluoro-6-methoxybenzaldehyde 99%

2-Fluoro-6-methoxybenzaldehyde99%

Benzaldehyde, 2-fluoro-6-methoxy- (9CI)

2-Fluoro-6-mehoxybenzaldehyde

3-Fluoro-2-formylanisole, 3-Fluoro-o-anisaldehyde

3-Fluoro-2-formylanisole, 6-Fluoro-o-anisaldehyde

2-<WBR>Fluoro-<WBR>6-<WBR>Methoxybenzaldehyde

Benzaldehyde, 2-fluoro-6-methoxy-

2-fluoro-6-methoxybenzaldehyde(WXC04222)

5-Isobutylacetophenone

2-Fluoro-6-methoxybenzaldenyde

146137-74-8

Organic Building Blocks

ALDEHYDE

Aldehydes

Building Blocks

Carbonyl Compounds

HALIDE

ALDEHYDE

Aromatic Aldehydes & Derivatives (substituted)