2-Fluoro-6-methoxybenzaldehyde
- Product Name
- 2-Fluoro-6-methoxybenzaldehyde
- CAS No.
- 146137-74-8
- Chemical Name
- 2-Fluoro-6-methoxybenzaldehyde
- Synonyms
- RARECHEM AK VD 0022;5-Isobutylacetophenone;6-FLUORO-O-ANISALDEHYDE;2-Fluoro-6-mehoxybenzaldehyde;2-METHOXY-6-FLUOROBENZALDEHYDE;2-FLUORO-6-METHOXYBENZALDEHYDE;2-Fluoro-6-methoxybenzaldenyde;2-Fluoro-6-methoxybenzaldehyde99%;Benzaldehyde, 2-fluoro-6-methoxy-;2-Fluoro-6-methoxybenzaldehyde 99%
- CBNumber
- CB4683092
- Molecular Formula
- C8H7FO2
- Formula Weight
- 154.14
- MOL File
- 146137-74-8.mol
2-Fluoro-6-methoxybenzaldehyde Property
- Melting point:
- 59-63 °C (lit.)
- Boiling point:
- 218.5±20.0 °C(Predicted)
- Density
- 0.807 g/mL at 25 °C
- refractive index
- n20/D 1.339
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- 5 wt.% in methanol
- color
- White to tan
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 146137-74-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 536733
- Product name
- 2-Fluoro-6-methoxybenzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $36
- Updated
- 2023/06/20
- Product number
- 536733
- Product name
- 2-Fluoro-6-methoxybenzaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $53.2
- Updated
- 2023/06/20
- Product number
- F1175
- Product name
- 6-Fluoro-o-anisaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- F1175
- Product name
- 6-Fluoro-o-anisaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $134
- Updated
- 2025/07/31
- Product number
- F401495
- Product name
- 2-Fluoro-6-methoxybenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
2-Fluoro-6-methoxybenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
off-white crystalline
Synthesis
456-49-5
68-12-2
146137-74-8
General procedure for the synthesis of 2-fluoro-6-methoxybenzaldehyde from m-fluoroanisole and N,N-dimethylformamide: n-butyllithium (1.6 M in hexane, 74.3 ml, 0.118 mol) was added slowly and dropwise to a solution of diisopropylamine (13.23 g, 0.130 mol) in tetrahydrofuran (50 ml) at 0 °C. After maintaining this temperature for 15 min, the reaction system was cooled to -78°C. Subsequently, a tetrahydrofuran (5 ml) solution of 3-fluoroanisole (15 g, 0.118 mol) was added and stirred at -78 °C for 1 hour. Next, N,N-dimethylformamide (6.75 ml) was added and stirring was continued at the same temperature for 1 hour. After completion of the reaction, the reaction was burst with 2N hydrochloric acid solution followed by extraction with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 2-fluoro-6-methoxybenzaldehyde as a red waxy solid (17.45 g, 95% yield), which could be used in subsequent steps without further purification.
References
[1] Patent: US2012/289496, 2012, A1. Location in patent: Page/Page column 100
[2] Chemistry - A European Journal, 2015, vol. 21, # 29, p. 10322 - 10325
[3] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7499 - 7502
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 12, p. 2998 - 3001
[5] Patent: WO2012/151525, 2012, A1. Location in patent: Page/Page column 100; 101
2-Fluoro-6-methoxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-6-methoxybenzaldehyde Suppliers
- Tel
- 320-37350700
- Fax
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View Lastest Price from 2-Fluoro-6-methoxybenzaldehyde manufacturers
- Product
- 2-Fluoro-6-methoxybenzaldehyde 146137-74-8
- Price
- US $0.00-0.00/g
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 2-Fluoro-6-methoxybenzaldehyde 146137-74-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 90%-99.9%
- Supply Ability
- 1000kg
- Release date
- 2019-07-04