3-Iodopyridin-2-amine
- Product Name
- 3-Iodopyridin-2-amine
- CAS No.
- 104830-06-0
- Chemical Name
- 3-Iodopyridin-2-amine
- Synonyms
- 3-iodo-2-aMinopyridine;3-IODOPYRIDIN-2-AMINE;3-Iodopyrid-2-ylaMine;3-IODO-2-PYRIDINAMINE;2-AMINO-3-IODOPYRIDINE;2-Pyridinamine, 3-iodo-;3-IODO-PYRIDIN-2-YLAMINE;2-Amino-3-iodopyridine >2-Amino-3-iodopyridine,98%;2-Amino-3-iodopyridine 97%
- CBNumber
- CB4704524
- Molecular Formula
- C5H5IN2
- Formula Weight
- 220.01
- MOL File
- 104830-06-0.mol
3-Iodopyridin-2-amine Property
- Melting point:
- 87-91 °C
- Boiling point:
- 289.6±25.0 °C(Predicted)
- Density
- 2.055±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- pka
- 4.50±0.36(Predicted)
- form
- Powder, Crystalline Powder or Needles
- color
- White to pale brown
- Sensitive
- Air & Light Sensitive
- InChI
- InChI=1S/C5H5IN2/c6-4-2-1-3-8-5(4)7/h1-3H,(H2,7,8)
- InChIKey
- UUDNBWSHTUFGDQ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC=C1I
- CAS DataBase Reference
- 104830-06-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 2
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 704474
- Product name
- 2-Amino-3-iodopyridine
- Purity
- 96%
- Packaging
- 5g
- Price
- $79.8
- Updated
- 2023/06/20
- Product number
- A2542
- Product name
- 2-Amino-3-iodopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- A2542
- Product name
- 2-Amino-3-iodopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- I719433
- Product name
- 3-Iodopyridin-2-amine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FA32708
- Product name
- 2-Amino-3-iodopyridine
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
3-Iodopyridin-2-amine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Needles
Uses
2-Amino-3-iodopyridine (3-Iodopyridin-2-amine) can be coupled with formyl derivatives under a copper-catalyzed indole synthesis method, and then constructed azide analogs through copper-mediated conjugated adducts things. The nucleophilicity of 2-Amino-3-iodopyridine is lower than that of the corresponding aniline used in the synthesis of indole, a potential obstacle for future synthesis[1].
Synthesis
113975-31-8
104830-06-0
General procedure for the synthesis of 2-amino-3-iodopyridine from N-(3-iodopyridin-2-yl)palmitamide: N-(3-iodopyridin-2-yl)neopentanamide (13.80 g, 45.36 mmol) was dissolved in 24 wt% sulfuric acid solution (394 mL), and the reaction mixture was stirred for 60 min under reflux conditions. After completion of the reaction, it was cooled to room temperature and neutralized with 4N sodium hydroxide solution and solid sodium bicarbonate. The aqueous phase was extracted with dichloromethane (3 x 200 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed by rotary evaporator to give 3-iodopyridin-2-amine (9.70 g, 97% yield) as a cream colored solid.
References
[1] Patent: US2009/156593, 2009, A1. Location in patent: Page/Page column 17
[2] Patent: US2006/183758, 2006, A1. Location in patent: Page/Page column 8
[3] Patent: US2009/82403, 2009, A1. Location in patent: Page/Page column 51
[4] Patent: US2007/105904, 2007, A1. Location in patent: Page/Page column 53
[5] Patent: US2010/331282, 2010, A1. Location in patent: Page/Page column 10
3-Iodopyridin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Iodopyridin-2-amine Suppliers
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- United Kingdom
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View Lastest Price from 3-Iodopyridin-2-amine manufacturers
- Product
- 3-Iodopyridin-2-amine 104830-06-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 2-Amino-3-iodopyridine 104830-06-0
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-04
- Product
- 3-Iodopyridin-2-amine 104830-06-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01