Oxipurinol

Product Name: Oxipurinol
CAS No.: 2465-59-0
Chemical Name: Oxipurinol
Synonyms: Oxyprim;BW-55-5;NSC-76239;OXIPURINOL;OXYPURINOL;1,7-Dihydro-;Alloxanthine;Oxoallopurinol;Allopurinol Impurity5;Allopurinol Impurity 6
CBNumber: CB4709190
Molecular Formula: C5H4N4O2
Formula Weight: 152.11
MOL File: 2465-59-0.mol

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Oxipurinol Property

Melting point:: 300 °C
Boiling point:: 274.55°C (rough estimate)
Density: 1.637
refractive index: 1.8500 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO.
pka: pKa 7.7 (Uncertain)
form: Powder
color: Light yellow
BRN: 139956
Stability:: Hygroscoipic
CAS DataBase Reference: 2465-59-0(CAS DataBase Reference)
EPA Substance Registry System: Oxypurinol (2465-59-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O6881
Product name: Oxypurinol
Purity: ≥98% (HPLC)
Packaging: 100mg
Price: $227
Updated: 2024/03/01

Sigma-Aldrich

Product number: 42688
Product name: Oxypurinol
Purity: analytical standard
Packaging: 10mg
Price: $99
Updated: 2022/05/15

Alfa Aesar

Product number: L07160
Product name: 4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%
Packaging: 1g
Price: $72.65
Updated: 2024/03/01

Alfa Aesar

Product number: L07160
Product name: 4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%
Packaging: 5g
Price: $238.65
Updated: 2024/03/01

Cayman Chemical

Product number: 18716
Product name: Oxipurinol
Purity: ≥95%
Packaging: 1g
Price: $115
Updated: 2024/03/01

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Oxipurinol Chemical Properties,Usage,Production

Chemical Properties

Off White Solid

Uses

4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine is an inhibitor to study the specificity and kinetics of xanthine oxidase. It is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.

Uses

Oxypurinol, an allopurinol metabolite, is used as an inhibitor to study the specificity and kinetics of of xanthine oxidase(s). Oxypurinol is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.

Uses

A metabolite of Allopurinol.

Definition

ChEBI: A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.

Biological Activity

oxipurinol is a xanthine oxidoreductase inhibitor.xanthine oxidoreductase (xo), a complex molybdoflavoenzyme present in milk and many other tissues, has been studied for many years. xo is generally recognized as a critical enzyme in purine catabolism.

Biochem/physiol Actions

An allopurinol metabolite.

in vitro

allopurinol could be rapidly oxidized by xo to its active metabolite oxypurinol (both isosteres of hypoxanthine and xanthine, respectively), which also could inhibit xo. oxypurinol was identified as a noncompetitive inhibitor of xo; the formation of this compound was reported to be responsible for much of the pharmacological activity of allopurinol. moreover, both allopurinol and oxypurinol showed free radical scavenging effects in isolated hearts, and exerted cardioprotective effects despite no detectable xo activities [1].

in vivo

animal study found that in the vasculature of hypercholesterolemic rabbits, oxypurinol treatment led to a decrease in vascular free radical production [1].

References

[1] p. pacher, a. nivorozhkin and c. szabó. therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. pharmacological reviews 58(1), 87-114 (2006).
[2] day ro, graham gg, hicks m, mclachlan aj, stocker sl, williams km. clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. clin pharmacokinet. 2007;46(8):623-44.

Oxipurinol Preparation Products And Raw materials

Raw materials

Diethyl oxalacetate Sodium hypochlorite Hydrazinium hydroxide solution Ethanol Acetic anhydride Triethyl orthoformate Diethyl oxalate Sodium Sodium ethoxide Diethyl ether Ethyl acetate

Preparation Products

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Oxipurinol Suppliers

Belgium 2 Canada 2 China 96 Germany 5 India 15 Japan 3 South Korea 1 Switzerland 2 United Kingdom 16 United States 35 Global 177

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View Lastest Price from Oxipurinol manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Oxipurinol 2465-59-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

2465-59-0, OxipurinolRelated Search:

Xanthine 8-Bromoguanosine 6-Mercaptopurine monohydrate 2-Thioxanthine 9-[(2-Acetoxyethoxy)methyl]-N2-acetylguanine Guanine hydrochloride Guanine Purine Uric acid 6-Hydroxypurine Oxipurinol Allopurinol-d2 Allopurinol ETHYL 5,7-DIHYDROXYPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE Allopurinol Related CoMpound F ALLOPURINOL IMPURITY C Allopurinol Impurity 1 5-(forMylaMino)-1H-pyrazole-4-carboxaMide

4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%

4,6-Dihydropyrazolo Pyrimidine

4,6-Dihydroxypyrazolo[3,4-d]pyrimidine,99%

4,6-Dihydroxypyrazolo[3,4-d]pyriMidine (Oxypurinol)

OXYPURINOL

OXIPURINOL

4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine

4,6-Dioxopyrazolo[3,4-d]pyrimidine

Oxyprim

4,6-Dihydroxypyrazolo[3,4-d]pyrimidine ,96%

4,6-Dihydroxypyrazolo[3,4-d]pyriMidine, 99% 5GR

1,7-Dihydro-

4,6-DIHYDROXYPYRAZOLE(3,4D)PYRIMIDINE

4,6-DIHYDROXYPYRAZOLO[3,4-D]PYRIMIDINE

1H-Pyrazolo[3,4-d]pyrimidin-4,6-diol

Oxoallopurinol

1H-PYRAZOLO[3,4-D]PYRIMIDINE-4,6(5H,7H)-DIONE

4,6-DIHYDROXYPYRAZOLO[3,4-D]PYRIMIDINE 99%

1H-pyrazolo[3,4-d]pyrimidine-4,6-diol

4,6-DIOXO-1,3A-DIHYDRO-PYRAZOLO[3,4-D]-PYRIMIDINE

4,6-Dihydroxypyrazolo3,4-düpyrimidine, 98%

4,6-Dihydroxypyrazolo3,4-düpyrimidine, 98+%

Alloxanthine

BW-55-5

NSC-76239

Allopurinol Impurity 6

4,6-Dihydroxypyrazolo[3,4-d]pyrimidine, 98+%

Allopurinol Impurity 2 (Oxypurinol)

Allopurinol Impurity1583

Allopurinol Impurity5

OxypurinolQ: What is Oxypurinol Q: What is the CAS Number of Oxypurinol Q: What is the storage condition of Oxypurinol Q: What are the applications of Oxypurinol

1,2-dihydropyrazolo[3,4-d]pyrimidine-4,6-dione

1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione

Lactic Acid Impurity 61

2465-59-0

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