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Flavin adenine dinucleotide disodium salt

Product Name
Flavin adenine dinucleotide disodium salt
CAS No.
84366-81-4
Chemical Name
Flavin adenine dinucleotide disodium salt
Synonyms
FAD;flavin adenine dinucleotide sodium;FAD Disodium Salt Hydrate;FLAVINE ADENINE DINUCLEOTIDE DISODIUM SALT;FACD;FANCD;FAD-N;FAD-NA2;FAD 2NA;FAD/FAD-Na2
CBNumber
CB4725259
Molecular Formula
C27H34N9NaO15P2
Formula Weight
809.55
MOL File
84366-81-4.mol
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Flavin adenine dinucleotide disodium salt Property

Melting point:
>203°C (dec.)
storage temp. 
2-8°C
solubility 
Methanol (Slightly, Heated), Water (Slightly)
form 
Powder
color 
yellow to orange-brown
Water Solubility 
5 g/L
Merck 
14,4091
BRN 
5326842
Stability:
Hygroscopic
InChI
InChI=1/C27H33N9O15P2.Na.H/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;/t14-,15+,16+,19-,20+,21+,26+;;/s3
InChIKey
PGEPWKYNISSNIQ-JQOOTDDSNA-N
SMILES
C(N1C2=CC(C)=C(C)C=C2N=C2C(NC(=O)N=C12)=O)[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@@H]1[C@H]([C@@H](O)[C@H](N2C=NC3=C(N=CN=C23)N)O1)O.[NaH] |&1:19,21,23,36,37,38,40,r|
CAS DataBase Reference
84366-81-4(CAS DataBase Reference)
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Safety

Safety Statements 
24/25-22
WGK Germany 
3
RTECS 
AU7470000
8-10-21
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F6625
Product name
Flavin adenine dinucleotide disodium salt hydrate
Purity
≥95% (HPLC), powder
Packaging
10mg
Price
$68.3
Updated
2024/03/01
Sigma-Aldrich
Product number
F6625
Product name
Flavin adenine dinucleotide disodium salt hydrate
Purity
≥95% (HPLC), powder
Packaging
1g
Price
$697
Updated
2024/03/01
TCI Chemical
Product number
F0014
Product name
Flavin Adenine Dinucleotide Disodium Salt Hydrate
Purity
>94.0%(HPLC)
Packaging
1g
Price
$210
Updated
2021/12/16
TCI Chemical
Product number
F0014
Product name
Flavin Adenine Dinucleotide Disodium Salt Hydrate
Purity
>94.0%(HPLC)
Packaging
100mg
Price
$44
Updated
2021/12/16
Alfa Aesar
Product number
A14495
Product name
Flavin adenine dinucleotide disodium salt hydrate, 94% (dry wt.), water <10%
Packaging
100mg
Price
$50.8
Updated
2021/12/16
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Flavin adenine dinucleotide disodium salt Chemical Properties,Usage,Production

Description

Flavin Adenine Dinucleotide Disodium Salt hydrate is an adenine-containing enzymatic redox cofactor. Also known as flavin cofactors and is critical electron transporter in living systems. FAD has been used as a predominant fluorophore to study unstained eosinophils, which exhibit autofluorescence compared to other leucocytes.

Chemical Properties

yellow-orange powder

Uses

The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase.

Uses

Used as a redox cofactor (electron carrier) for flavoproteins including succinate dehydrogenase (complex), alpha-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2) , AMID), folate/FAD-dependent tRNA methyltransferase, and N-hydroxylated flavoprotein monooxygenase.

Definition

ChEBI: Flavin adenine dinucleotide disodium is a flavin nucleotide.

Application

Flavin adenine dinucleotide disodium salt is the sodium salt form of Flavin adenine dinucleotide (FAD). FAD is used by flavoproteins as redox cofactors (electron carriers), including succinate dehydrogenase (complex), α-ketoglutarate dehydrogenase, apoptosis inducing factor 2 (AIF-M2, AMID), folate/FAD-dependent tRNA methyltransferase, and N-hydroxylated flavoprotein monooxygenase. FAD is a component of the pyruvate dehydrogenase complex. Flavin adenine dinucleotide disodium salt hydrate has been used as a component of plant tissue extraction buffers.

Biological Activity

Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, a prosthetic group of proteins, involved in several important enzymatic reactions during metabolism.

in vitro

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.

in vivo

With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.

Purification Methods

Small quantities of FAD are purified by paper chromatography using tert-butyl alcohol/water, cutting out the main spot and eluting with water. Larger amounts can be precipitated from water as the uranyl complex by adding a slight excess of uranyl acetate to a solution at pH 6.0, dropwise and with gentle stirring. The solution is set aside overnight in the cold, and the precipitate is centrifuged off, washed with small portions of cold EtOH, then with cold peroxide-free diethyl ether. It is dried in the dark under vacuum over P2O5 at 50-60o. The uranyl complex is suspended in water, and, after adding sufficient 0.01M NaOH to adjust the pH to 7, the precipitate of uranyl hydroxide is removed by centrifugation [Huennekens & Felton Methods Enzymol 3 954 1957]. It can also be crystallised from water. It should be kept in the dark. More recently it was purified by elution from a DEAE-cellulose (Whatman DE 23) column with 0.1M phosphate buffer pH 7, and the purity was checked by TLC. [Holt & Cotton, J Am Chem Soc 109 1841 1987, Beilstein 26 III/IV 3632.]

Flavin adenine dinucleotide disodium salt Preparation Products And Raw materials

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View Lastest Price from Flavin adenine dinucleotide disodium salt manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Flavin adenine dinucleotide disodium salt 84366-81-4
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99% HPLC
Supply Ability
10000
Release date
2024-09-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Riboflavin 5'-adenosine diphosphate disodium salt 84366-81-4
Price
US $0.00/g
Min. Order
1g
Purity
≥95.0%
Supply Ability
1kg/month
Release date
2021-09-28
Hebei Yanxi Chemical Co., Ltd.
Product
Flavin adenine dinucleotide disodium salt 84366-81-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-15

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