5-BROMO-2-FLUORO-6-PICOLINE
- Product Name
- 5-BROMO-2-FLUORO-6-PICOLINE
- CAS No.
- 375368-83-5
- Chemical Name
- 5-BROMO-2-FLUORO-6-PICOLINE
- Synonyms
- 3-Bromo-6-fluoro-2-methylpyridine;5-BROMO-2-FLUORO-6-PICOLINE;5-Bromo-2-flouro-6-picoline;5-Bromo-2-fluoro-6-methylpyridine;Pyridine,3-bromo-6-fluoro-2-methyl-;5-BROMO-2-FLUORO-6-PICOLINE ISO 9001：2015 REACH
- CBNumber
- CB4754716
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 375368-83-5.mol
5-BROMO-2-FLUORO-6-PICOLINE Property
- Boiling point:
- 189.5±35.0 °C(Predicted)
- Density
- 1.592±0.06 g/cm3(Predicted)
- refractive index
- 1.5270-1.5310
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- -2.07±0.10(Predicted)
- color
- Colorless to Light yellow
- InChI
- InChI=1S/C6H5BrFN/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3
- InChIKey
- GUYGQQWIKZLHTP-UHFFFAOYSA-N
- SMILES
- C1(C)=NC(F)=CC=C1Br
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B5135
- Product name
- 3-Bromo-6-fluoro-2-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- B5135
- Product name
- 3-Bromo-6-fluoro-2-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $160
- Updated
- 2025/07/31
- Product number
- B692663
- Product name
- 3-Bromo-6-fluoro-2-methylpyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B10104
- Product name
- 3-Bromo-6-fluoro-2-methylpyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $5
- Updated
- 2021/12/16
- Product number
- PC7144
- Product name
- 3-Bromo-6-fluoro-2-methylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
5-BROMO-2-FLUORO-6-PICOLINE Chemical Properties,Usage,Production
Chemical Properties
Light yellow powder
Uses
5-Bromo-2-fluoro-6-methylpyridine is a Light yellow powder, it is used as an intermediate in organic synthesis and is widely used in the fields of pesticide, medicine and materials science.
Synthesis
42753-71-9
375368-83-5
The general procedure for the synthesis of 3-bromo-2-methyl-6-fluoropyridine from 2-amino-5-bromo-6-methylpyridine was as follows: 5-bromo-2-amino-6-methylpyridine (5 g) was dissolved in pyridine hydrogen fluoride (35 mL). The reaction system was cooled to -20°C, followed by the slow addition of potassium nitrite (KNO2, 2.7 g). The reaction was continued by keeping the temperature low. Once the reaction was complete, it was slowly warmed to room temperature and stirred continuously for 4 hours. The reaction mixture was slowly poured into ice water (200 mL) and extracted with a solvent mixture of dichloromethane (50 mL) and ethyl acetate (EtOAc). The organic phases were combined, washed with 1N hydrochloric acid solution and concentrated under reduced pressure to give 5-bromo-2-fluoro-6-methylpyridine (4 g, 78% yield).
References
[1] Patent: CN108341769, 2018, A. Location in patent: Paragraph 0021-0023; 0025-0027
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 22, p. 3979 - 3982
5-BROMO-2-FLUORO-6-PICOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2-FLUORO-6-PICOLINE manufacturers
- Product
- 5-BROMO-2-FLUORO-6-PICOLINE 375368-83-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 3-Bromo-6-fluoro-2-methylpyridine 375368-83-5
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 5-BROMO-2-FLUORO-6-PICOLINE 375368-83-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25