2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 174346-82-8
Chemical Name: 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: tert-Butyl 2-(hydroxyMethyl)azetidine-1-carboxylate;1-Boc-2-azetidinemethanol;N-Boc-2-azetidinemethanol;1-BOC-2-HYDROXYMETHYL-AZETIDINE;1-Boc-2-azetidinemethanol - [B8003];1-(tert-Butoxycarbonyl)-2-azetidinemethanol;[1-(TERT-BUTOXYCARBONYL)AZETIDIN-2-YL]METHANOL;R,S-1-[(1,1-Dimethylethoxy)carbonyl]azetidine-2-methanol;2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester
CBNumber: CB4763691
Molecular Formula: C9H17NO3
Formula Weight: 187.24
MOL File: 174346-82-8.mol

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2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 270.3±13.0 °C(Predicted)
Density: 1.115±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.77±0.10(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B809838
Product name: [1-(tert-Butoxycarbonyl)azetidin-2-yl]methanol
Packaging: 1g
Price: $160
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-MC
Product name: 1-Boc-2-azetidinemethanol
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Synthonix

Product number: B8003
Product name: 1-Boc-2-azetidinemethanol
Purity: 97.0%
Packaging: 1g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-MC
Product name: 1-Boc-2-azetidinemethanol
Packaging: 1g
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1051910
Product name: TERT-BUTYL-2-(HYDROXYMETHYL)AZETIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $457.16
Updated: 2021/12/16

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2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

[1-(tert-Butoxycarbonyl)azetidin-2-yl]methanol is used as a potential positiron emission tomography imaging agents for nicotinic acetylcholine receptors.

Synthesis

159749-28-7

174346-82-8

General procedure for the synthesis of tert-butyl 2-hydroxymethyl-azetidine-1-carboxylate from N-Boc-azetidine-2-carboxylic acid: to a solution of N-Boc-azetidine-2-carboxylic acid (1.45 g, 7.21 mmol) in anhydrous THF (12 mL) was added slowly and dropwise borane-methyl sulfide complex (10 M, 3 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched with methanol (10 mL) followed by dilution of the reaction mixture with dichloromethane (100 mL). The organic phase was washed with water (40 mL x 3), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford tert-butyl 2-hydroxymethyl-azetidine-1-carboxylate (1.25 g) as a colorless oil.MS-ESI (m/z): 132.0 [M+1-56]+.

References

[1] Patent: WO2015/7219, 2015, A1. Location in patent: Page/Page column 38

2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 68 Germany 1 India 1 United States 11 Global 81

Alchem Pharmtech,Inc.

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View Lastest Price from 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 174346-82-8
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

174346-82-8, 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

Azetidine (S)-N-BOC-AZETIDINE-2-CARBOXYLIC ACID METHYL ESTER 1-Boc-L-azetidine-2-carboxylic acid AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-ETHYL ESTER (3-[2(S)-N-(TERT-BUTOXYCARBONYL)-2-AZETIDINYL-METHOXY]PYRIDIN-2-YL)TRIMETHYLAMMONIUM TRIFLUOROMETHANESULFONATE Boc-D-Azetidine-2-carboxylic acid (R)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL 2-[[(2-FLUORO-3-PYRIDINYL)OXY]METHYL]-1-AZETIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 2-IODO-3-(1-TERT-BUTOXYCARBONYL-2-(S)-AZETIDINYLMETHOXY)PYRIDINE Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 1-Boc-azetidine-2-carboxylic acid methyl ester (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL 1-AZETIDINECARBOXYLIC ACID, 2-[[[2-NITRO-3-PYRIDINYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER, (2S)- (2S)-2-[[[5-(TRIMETHYLSTANNYL)-3-PYRIDINYL]OXY]METHYL]-1-AZETIDINECARBOXYLIC ACID, T-BUTYL ESTER 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER H-SAR-OTBU HCL 1-N-Boc-2-(hydroxymethyl)piperazine

2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

[1-(TERT-BUTOXYCARBONYL)AZETIDIN-2-YL]METHANOL

1-BOC-2-HYDROXYMETHYL-AZETIDINE

1-Boc-2-azetidinemethanol

tert-Butyl 2-(hydroxyMethyl)azetidine-1-carboxylate

N-Boc-2-azetidinemethanol

R,S-1-[(1,1-Dimethylethoxy)carbonyl]azetidine-2-methanol

1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

1-(tert-Butoxycarbonyl)-2-azetidinemethanol

1-Boc-2-azetidinemethanol - [B8003]

174346-82-8