Ozagrel hydrochloride

Product Name: Ozagrel hydrochloride
CAS No.: 78712-43-3
Chemical Name: Ozagrel hydrochloride
Synonyms: Vega;Ozag;Domenan;OKY-046 HCl;(e)-ohydrat;OZAGREL HCL;OzagrelHcl99%;oky046hydrochloride;Ozagrel Impurity 44;oky-046hydrochloride
CBNumber: CB4765488
Molecular Formula: C13H13ClN2O2
Formula Weight: 264.71
MOL File: 78712-43-3.mol

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Ozagrel hydrochloride Property

Melting point:: 214-217°
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: H₂O: soluble
form: solid
color: white to off-white
Water Solubility: H2O: soluble
Merck: 14,6980
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
CAS DataBase Reference: 78712-43-3(CAS DataBase Reference)

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Safety

RIDADR: 3077
WGK Germany: 2
RTECS: UD3380000
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O1385
Product name: Ozagrel hydrochloride hydrate
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $116
Updated: 2025/07/31

Sigma-Aldrich

Product number: O1385
Product name: Ozagrel hydrochloride hydrate
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $354
Updated: 2022/05/15

TCI Chemical

Product number: O0419
Product name: Ozagrel Hydrochloride Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: O0419
Product name: Ozagrel Hydrochloride Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $118
Updated: 2025/07/31

Tocris

Product number: 1510
Product name: Ozagrelhydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $104
Updated: 2021/12/16

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Ozagrel hydrochloride Chemical Properties,Usage,Production

Description

Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane A2 (TXA2) synthetase (IC50 = 4 nM). It does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase, or PGE2 isomerase (IC50 > 1 mM)[1]. Ozagrel HCl inhibits platelet aggregation in vitro[2] and arachidonate-induced arterial contraction in vivo. It protects against arachidonate-induced sudden death in rabbits[3] and alleviates liver injury induced by acetaminophen overdose in mice[4].

History

Ozagrel hydrochloride was initially developed jointly by Ono Pharmaceutical Co., Ltd. and Kissei Pharmaceutical Co., Ltd. in Japan. Approved for marketing in Japan in 1988, it became the world's first commercially available potent thromboxane A2 (TXA2) synthase inhibitor. This medication is primarily indicated for the treatment of patients with ischaemic cerebrovascular disease, as it exhibits dual effects of inhibiting platelet aggregation and dilating blood vessels, thereby effectively preventing thrombus formation.

Uses

Ozagrel Hydrochloride is a selective thromboxane A2 synthase inhibitor, which alleviates liver injury induced by acetaminophen overdose in mice.

Definition

ChEBI: Ozagrel hydrochloride is an organic molecular entity.

IC 50

TXA₂/TP

References

[1] SEIJI HIRAKU . Pharmacological Studies on the TXA2 Synthetase Inhibitor (E)-3-[p(1H-lmidazol-1-Ylmethyl)Phenyl]-2-Propenoic Acid (OKY-046)[J]. Japanese journal of pharmacology, 1986, 41 3: Pages 393-401. DOI:10.1254/jjp.41.393
[2] JUN NAITO . Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets[J]. European journal of pharmacology, 1983, 91 1: Pages 41-48. DOI:10.1016/0014-2999(83)90359-x
[3] LEE C. EDMONDS Allan M L. Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death[J]. Life sciences, 1984, 35 17: Pages 1763-1768. DOI:10.1016/0024-3205(84)90273-x
[4] YOSHIRO TOMISHIMA. Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.[J]. BMC Gastroenterology, 2013, 13: 21. DOI:10.1186/1471-230x-13-21

Ozagrel hydrochloride Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from Ozagrel hydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ozagrel hydrochloride 78712-43-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: Ozagrel hydrochloride 78712-43-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-19

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OKY-046, (E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrate hydrochloride

Ozagrel hydrate hydrochloride

Domenan

OKY-046 HCl

Vega

Ozagrel hydrochloride hydrate,(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate, OKY-046

(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid,hydrochloride (1:1)

(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate

Hydrochloride Ozagrel

(E)-3-(4-((1H-Imidazol-1-yl)methyl)phenyl)acrylic acid hydrochloride

Ozagrel hydrochloride hydrate, 99%, a selective thromboxane A(2) synthetase inhibitor

(E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid hydrochloride

Ozag

(e)-3-(4-(1h-imidazol-1-ylmethyl)phenyl)-2-propenoicacidhydrochloridehydra

(e)-ohydrat

2-propenoicacid,3-(4-(1h-imidazol-1-ylmethyl)phenyl)-,monohydrochloride,mon

oky046hydrochloride

oky-046hydrochloride

OZAGREL HYDROCHLORIDE HYDRATE

OzagrelHcl99%

OzagrelHclC13H12N2O2.Hcl

(e)-3-[4-(imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride

(e)-3-(4-(1h-imidazol-1-ylmethyl)phenyl)-2-propenoic acid hydrochloride

OZAGREL HCL

OZAGREL HYDROCHLORIDE

(2E)-3-[4-(1H-IMIDAZOL-1-YLMETHYL)PHENYL]-2-PROPENOIC ACID HYDROCHLORIDE

OzagrelHydrochlorideHydrate&gt

Ozagrel Impurity 44

(E)-Ozagrel hydrochloride

trans-4-[(1-Imidazolyl)methyl]cinnamic Acid Hydrochloride

Ozagrel hydrochloride USP/EP/BP

Ozagrel HCl (OKY046 HCl

Ozagrel hydrochloride, 10 mM in DMSO

Ozagrel HCl - Bio-X ?

78712-43-3

C13H12N2O2ClH

C13H12N2O2HCl

C13H12N2O2HClxH2O

C13H12N2O2ClHH2O

R to Z

Thromboxane A2 synthase

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Biochemicals and Reagents

BioChemical

Enzymes, Inhibitors, and Substrates

Inhibitors

Piperidones ,Piperidines ,Homopiperidines

Cardiovascular