ChemicalBook > CAS DataBase List > Ethyl N-Boc-piperidine-4-carboxylate
Ethyl N-Boc-piperidine-4-carboxylate
- Product Name
- Ethyl N-Boc-piperidine-4-carboxylate
- CAS No.
- 142851-03-4
- Chemical Name
- Ethyl N-Boc-piperidine-4-carboxylate
- Synonyms
- 1-TERT-BUTYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE;N-BOC-4-CARBETHOXY PIPERIDINE;Ethyl N-Boc-4-piperidinecarboxylate;1-Boc-isonipecotic acid ethyl ester;PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-ETHYL ESTER;calboxylate;BUTTPARK 153\33-50;ETHYL N-BOC-ISONIPECOTATE;1-Boc-piperidine-4-carboxyL;1-Boc-4-Carbethoxy Piperidine
- CBNumber
- CB4781820
- Molecular Formula
- C13H23NO4
- Formula Weight
- 257.33
- MOL File
- 142851-03-4.mol
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Ethyl N-Boc-piperidine-4-carboxylate Property
- Boiling point:
- 120-135 °C/0.5 mmHg
- Density
- 1.046 g/mL at 25 °C
- refractive index
- n20/D 1.458
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform, Ethyl Acetate
- pka
- -2.23±0.40(Predicted)
- form
- Liquid
- color
- Clear colorless to pale yellow
- InChI
- InChI=1S/C13H23NO4/c1-5-17-11(15)10-6-8-14(9-7-10)12(16)18-13(2,3)4/h10H,5-9H2,1-4H3
- InChIKey
- MYHJCTUTPIKNAT-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(C(OCC)=O)CC1
- CAS DataBase Reference
- 142851-03-4(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 665150
- Product name
- Ethyl N-Boc-piperidine-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $34.59
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 665150
- Product name
- Ethyl N-Boc-piperidine-4-carboxylate
- Purity
- 97%
- Packaging
- 25g
- Price
- $132.3
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2740
- Product name
- Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $27
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2740
- Product name
- Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $108
- Updated
- 2025/07/31
Usbiological
- Product number
- 449692
- Product name
- Ethyl N-Boc-piperidine-4-carboxylate
- Packaging
- 5g
- Price
- $312
- Updated
- 2021/12/16
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Ethyl N-Boc-piperidine-4-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Liquid
Uses
Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.
Uses
Substrate used in a palladium-catalyzed α-arylation of esters with heterocyclic bromides and chlorides leading to, for example, 4-pyridylpiperidinyl esters.
Synthesis
24424-99-5
142851-03-4
The general procedure for the synthesis of ethyl N-Boc-4-piperidinecarboxylate from di-tert-butyl dicarbonate was as follows: ethyl isopiperidinate (5.00 g, 0.032 mol) and triethylamine (4.9 mL, 0.035 mol) were dissolved in dichloromethane (25 mL) at 0 °C, and the dichloromethane of di-tert-butyl dicarbonate (7.2 g, 0.033 mol) was slowly added ( 25mL) solution. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, it was washed three times with potassium bisulfate solution and then once with brine. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford the target product ethyl N-Boc-4-piperidinecarboxylate (8.23 g, 100% yield) as a colorless oil. The structure of the product was confirmed by 1H NMR (C6D6,500MHz) δ 3.88 (q, J=7.5Hz, 2H), 2.52 (m, 1H), 1.60-1.48 (m, 8H), 1.42 (s, 9H), 0.92 (t, 3H) and mass spectra (280.44 (M+Na)+).
References
[1] Patent: US2004/204397, 2004, A1
[2] Patent: US2003/144302, 2003, A1
[3] Patent: US2002/55631, 2002, A1
[4] Patent: US2002/86887, 2002, A1
[5] Patent: US5716965, 1998, A
Ethyl N-Boc-piperidine-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl N-Boc-piperidine-4-carboxylate manufacturers
Anhui Zhongda Biotechnology Co., Ltd
- Product
- Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-10-26
Hebei Mingeng Biotechnology Co., Ltd
- Product
- Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4
- Price
- US $120.00/KG
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 500kg/month
- Release date
- 2021-12-16
LY Global chemicals co.,ltd .
- Product
- Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98% Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-18
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