ChemicalBook > CAS DataBase List > Ethyl N-Boc-piperidine-4-carboxylate

Ethyl N-Boc-piperidine-4-carboxylate

Product Name
Ethyl N-Boc-piperidine-4-carboxylate
CAS No.
142851-03-4
Chemical Name
Ethyl N-Boc-piperidine-4-carboxylate
Synonyms
1-TERT-BUTYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE;N-BOC-4-CARBETHOXY PIPERIDINE;Ethyl N-Boc-4-piperidinecarboxylate;1-Boc-isonipecotic acid ethyl ester;PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-ETHYL ESTER;calboxylate;BUTTPARK 153\33-50;ETHYL N-BOC-ISONIPECOTATE;1-Boc-piperidine-4-carboxyL;1-Boc-4-Carbethoxy Piperidine
CBNumber
CB4781820
Molecular Formula
C13H23NO4
Formula Weight
257.33
MOL File
142851-03-4.mol
More
Less

Ethyl N-Boc-piperidine-4-carboxylate Property

Boiling point:
120-135 °C/0.5 mmHg
Density 
1.046 g/mL at 25 °C
refractive index 
n20/D 1.458
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform, Ethyl Acetate
pka
-2.23±0.40(Predicted)
form 
Liquid
color 
Clear colorless to pale yellow
InChI
InChI=1S/C13H23NO4/c1-5-17-11(15)10-6-8-14(9-7-10)12(16)18-13(2,3)4/h10H,5-9H2,1-4H3
InChIKey
MYHJCTUTPIKNAT-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C(OCC)=O)CC1
CAS DataBase Reference
142851-03-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
665150
Product name
Ethyl N-Boc-piperidine-4-carboxylate
Purity
97%
Packaging
5g
Price
$34.59
Updated
2025/07/31
Sigma-Aldrich
Product number
665150
Product name
Ethyl N-Boc-piperidine-4-carboxylate
Purity
97%
Packaging
25g
Price
$132.3
Updated
2025/07/31
TCI Chemical
Product number
B2740
Product name
Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate
Purity
>97.0%(GC)
Packaging
5g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
B2740
Product name
Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate
Purity
>97.0%(GC)
Packaging
25g
Price
$108
Updated
2025/07/31
Usbiological
Product number
449692
Product name
Ethyl N-Boc-piperidine-4-carboxylate
Packaging
5g
Price
$312
Updated
2021/12/16
More
Less

Ethyl N-Boc-piperidine-4-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Liquid

Uses

Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.

Uses

Substrate used in a palladium-catalyzed α-arylation of esters with heterocyclic bromides and chlorides leading to, for example, 4-pyridylpiperidinyl esters.

Synthesis

24424-99-5

142851-03-4

The general procedure for the synthesis of ethyl N-Boc-4-piperidinecarboxylate from di-tert-butyl dicarbonate was as follows: ethyl isopiperidinate (5.00 g, 0.032 mol) and triethylamine (4.9 mL, 0.035 mol) were dissolved in dichloromethane (25 mL) at 0 °C, and the dichloromethane of di-tert-butyl dicarbonate (7.2 g, 0.033 mol) was slowly added ( 25mL) solution. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, it was washed three times with potassium bisulfate solution and then once with brine. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford the target product ethyl N-Boc-4-piperidinecarboxylate (8.23 g, 100% yield) as a colorless oil. The structure of the product was confirmed by 1H NMR (C6D6,500MHz) δ 3.88 (q, J=7.5Hz, 2H), 2.52 (m, 1H), 1.60-1.48 (m, 8H), 1.42 (s, 9H), 0.92 (t, 3H) and mass spectra (280.44 (M+Na)+).

References

[1] Patent: US2004/204397, 2004, A1
[2] Patent: US2003/144302, 2003, A1
[3] Patent: US2002/55631, 2002, A1
[4] Patent: US2002/86887, 2002, A1
[5] Patent: US5716965, 1998, A

Ethyl N-Boc-piperidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ethyl N-Boc-piperidine-4-carboxylate Suppliers

Americas 1 Belgium 1 Canada 1 China 231 Europe 3 Germany 5 India 24 Japan 3 Slovakia 1 Switzerland 2 United Kingdom 12 United States 45 Global 329
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Japan
Tel
--
Fax
--
Email
@TCIchemicals.com
Country
Japan
ProdList
2741
Advantage
58
TCI Chemical Trading Co., Ltd.
Tel
--
Fax
--
Email
sales@tci-chemical-trading.com
Country
Japan
ProdList
597
Advantage
58
More
Less

View Lastest Price from Ethyl N-Boc-piperidine-4-carboxylate manufacturers

Anhui Zhongda Biotechnology Co., Ltd
Product
Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100tons
Release date
2023-10-26
Hebei Mingeng Biotechnology Co., Ltd
Product
Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4
Price
US $120.00/KG
Min. Order
10g
Purity
99%
Supply Ability
500kg/month
Release date
2021-12-16
LY Global chemicals co.,ltd .
Product
Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98% Min
Supply Ability
1000kg
Release date
2023-03-18

142851-03-4, Ethyl N-Boc-piperidine-4-carboxylateRelated Search:

BUTYL OLEATE Ethyl propionate Ethylparaben Buprofezin Cyclohexanecarboxylic acid ethyl ester Ethanol OXALIC ACID Ethyl formate Trinexapac-ethyl ISOXADIFEN-ETHYL Ethyl 4-piperidinecarboxylate Urethane Ethyl cyanoformate Ethyl nipecotate Ethyl acetate 2-Ethoxyethanol Isonipecotic acid Cyhalofop-butyl

  • N-BOC-4-CARBETHOXY PIPERIDINE
  • PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-ETHYL ESTER
  • 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
  • 1-TERT-BUTYL 4-ETHYL 1,4-PIPERIDINEDICARBOXYLATE
  • 1-TERT-BUTYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
  • 1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE
  • Ethyl <I>N</I>-<WBR>Boc-<WBR>piperidine-<WBR>4-<WBR>carboxylate
  • N-BOC-4-piperidine forMic acid ethyl ester
  • Ethyl 1-Boc-piperidine-4-carboxylate, 95+%
  • N - bok - 4 - piperidine ethyl forMate
  • Ethyl N-Boc-piperidine-4-calboxylate
  • ETHYL N-BOC-ISONIPECOTATE
  • ETHYL N-BOC-PIPERIDIN-4-YL CARBOXYLATE
  • 1-Tert-butyl-4-ethyl 1,4-piperidie
  • N-Boc-Piperidine-4-carboxylate or ethyl 1-Boc-piperidine-4-carboxylate
  • 1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)piperidine
  • 1-tert-Butyl 4-ethyl piperidine-1,4-dicarboxylate 95+%
  • Ethyl <i>N</i>-boc-piperidine-4-carboxylate
  • Ethyl N-Boc-piperidine-4-carboxylate 97%
  • N-BOC-4-Carbethoxy-4-Piperidone
  • ETHYL N-BOC-PIPERIDINE-4-CARBOXYLATE
  • ETHYL 1-(TERT-BUTYLOXYCARBONYL)ISONIPECOTATE
  • ETHYL 1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINECARBOXYLATE
  • ETHYL 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLATE
  • DIMETHYLETHYL PIPERIDINEDICARBOXYLIC ACID ETHYL ESTER
  • BUTTPARK 153\33-50
  • 1-Boc-4-Carbethoxy Piperidine
  • N-Butoxycarbonyl-4-carbethoxy piperidine
  • Ethyl1-tert-buthoxycarbonylpyridine-4-carboxylate
  • Ethyl N-Boc-4-piperidinecarboxylate
  • 1-(tert-butyl) 4-ethyl tetrahydro-1,4(2H)-pyridinedicarboxylate (en)
  • Ethyl 1-(tert-butoxycarbonyl)-4-piperidinecarboxylate, Ethyl 1-(tert-Butyloxycarbonyl)isonipecotate, Piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
  • tert-butyl ethyl piperidine-1,4-dicarboxylate
  • 1-Boc-isonipecotic acid ethyl ester, 97+%
  • N-Boc-piperidine-4-carboxylic acid ethyl ester
  • Ethyl piperidine-4-carboxylate, N-BOC protected 95+%
  • 1-Boc-isonipecotic acid ethyl ester
  • 1-tert-butyl ester 4-ethyl ester
  • 1-tert-Butyl 4-ethyl piperidine-1,4-dicarboxylate, 1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)piperidine
  • 1,4-Piperidinedicarboxylic acid, 1-(1,1-diMethylethyl) 4-ethyl ester
  • China manufacturing Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4
  • 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid Ethyl Ester
  • China manufacturing Ethyl N-Boc-piperidine-4-carboxylate
  • Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate &gt
  • 1-Boc-piperidine-4-carboxyL
  • N-BOC isonipecotic acid ethyl ester
  • N-Boc-piperidine-4-carboxylate, ethyl ester
  • 1-Boc-4-piperidinecarboxylic Acid Ethyl Ester
  • Ethyl 1-Boc-4-piperidinecarboxylate
  • Piperidine-1,4-dicarboxylic Acid 1-tert-Butyl 4-Ethyl Ester
  • Ethyl N-Boc-piperidine-4-carboxylate USP/EP/BP
  • 1-O-tert-butyl 4-O-ethyl piperidine-1,4-dicarboxylate
  • calboxylate
  • Ethyl-N-BOC-4-Piperidine-4-Carboxylate
  • N-Boc-4-piperidinecarboxylic acid ethyl ester
  • 142851-03-4
  • Esters
  • Pyrans, Piperidines &Piperazines