Tenatumomab

Product Name: Tenatumomab
CAS No.: 1412891-40-7
Chemical Name: Tenatumomab
Synonyms: Tenatumomab;Research Grade Tenatumomab;Tenatumomab (anti-Tenascin C);Research Grade Tenatumomab (DHD64001)
CBNumber: CB48080774
Formula Weight: 0
MOL File: Mol file

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Tenatumomab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Tenatumomab Chemical Properties,Usage,Production

Uses

Tenatumomab (ST2146) is a murine monoclonal antibody against tenascin-C. And tenascin-C, the large extracellular glycoprotein, is overexpressed in cancer. Tenatumomab has been used for Pretargeted Antibody Guided Radioimmunoresearch (PAGRIT), and delivering radionuclides to tumors via PAGRIT and direct 131Iodine labeling approach[1][2].

in vivo

Tenatumomab (4 μg/mouse; i.v.; single dose) shows a biodistribution associated with low and high tenascin expression in nude mice transplanted with human HT-29 colon carcinoma and/or human U-118MG glioblastoma cells, respectively^[2].

References

[1] Giannini G, et al. Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors. Bioorg Med Chem. 2019 Aug 1;27(15):3248-3253. DOI:10.1016/j.bmc.2019.05.047
[2] De Santis R, et al. Low and high tenascin-expressing tumors are efficiently targeted by ST2146 monoclonal antibody. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2191-6. DOI:10.1158/1078-0432.CCR-05-2526

Tenatumomab Preparation Products And Raw materials

Raw materials

Preparation Products

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Tenatumomab Suppliers

China 15 United States 1 Global 16

Shanghai YuanYe Biotechnology Co., Ltd.

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Tenatumomab

Research Grade Tenatumomab (DHD64001)

Research Grade Tenatumomab

Tenatumomab (anti-Tenascin C)

1412891-40-7