2-Bromo-5-trifluoromethylphenol

Product Name: 2-Bromo-5-trifluoromethylphenol
CAS No.: 402-05-1
Chemical Name: 2-Bromo-5-trifluoromethylphenol
Synonyms: 2-Bromo-5-trifluoromethylphenol;5-BROMO-3-TRIFLUOROMETHYLPHENOL;5-Bromo-2-Trifluoromethyl-Phenol;2-Bromo-3-(trifluoromethyl)phenol;Phenol, 2-bromo-5-(trifluoromethyl)-;5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID)
CBNumber: CB4855015
Molecular Formula: C7H4BrF3O
Formula Weight: 241.01
MOL File: 402-05-1.mol

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2-Bromo-5-trifluoromethylphenol Property

Melting point:: 22-23°
Boiling point:: 56.0-57.5 °C(Press: 3.5-4.0 Torr)
Density: 1.752
storage temp.: Inert atmosphere,Room Temperature
form: Liquid
pka: 7.43±0.10(Predicted)
color: Pale brown

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Safety

RIDADR: UN1760
HazardClass: IRRITANT
HazardClass: 8
HS Code: 2905599890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H332Harmful if inhaled

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B695955
Product name: 2-Bromo-5-trifluoromethylphenol
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: B695955
Product name: 2-Bromo-5-trifluoromethylphenol
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB64425
Product name: 2-Bromo-5-(trifluoromethyl)phenol
Packaging: 5G
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0353134
Product name: 2-BROMO-5-TRIFLUOROMETHYLPHENOL
Purity: 95.00%
Packaging: 5MG
Price: $495.19
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB64425
Product name: 2-Bromo-5-(trifluoromethyl)phenol
Packaging: 25g
Price: $500
Updated: 2021/12/16

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2-Bromo-5-trifluoromethylphenol Chemical Properties,Usage,Production

Chemical Properties

light brown liquid

Uses

2-Bromo-3-(trifluoromethyl)phenol is used as a reactant in the synthesis of benzimidazolone and benzothiazolone compounds as AMPA receptor modulators.

Synthesis

98-17-9

402-05-1

General procedure for the synthesis of 2-bromo-5-trifluoromethylphenol from 3-trifluoromethylphenol: To a stirred solution of 61.65 g (0.38 mol) of 3-trifluoromethylphenol dissolved in 240 ml of carbon disulfide, 19.6 ml (0.38 mol) of bromine was slowly added dropwise. The reaction mixture was stirred continuously at room temperature for about 18 hours. Subsequently, the reaction solution was partitioned between 200 ml of dichloromethane and 100 ml of water. The organic phase was separated, washed with 20 mL of saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using dichloromethane containing 40% hexane as eluent. The eluate containing the target product was collected and concentrated under reduced pressure to give 48.8 g (53% yield) of 2-bromo-5-trifluoromethylphenol as a yellow oil. Ion spray mass spectrometry (MS) analysis showed m/e = 239,241 (M + 1).

References

[1] Journal of the American Chemical Society, 1951, vol. 73, p. 1325
[2] Journal of Organic Chemistry, 1951, vol. 16, p. 586,606
[3] Patent: US6638936, 2003, B1

2-Bromo-5-trifluoromethylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-trifluoromethylphenol Suppliers

China 117 Germany 1 India 3 United Kingdom 2 United States 15 Global 138

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View Lastest Price from 2-Bromo-5-trifluoromethylphenol manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: 2-Bromo-5-trifluoromethylphenol 402-05-1
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-04

Career Henan Chemical Co

Product: 2-Bromo-5-trifluoromethylphenol 402-05-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-30

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5-BROMO-3-TRIFLUOROMETHYLPHENOL

5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID)

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402-05-1

C7H4OBrF3

Fluorine series