2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine

Product Name: 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
CAS No.: 179687-79-7
Chemical Name: 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
Synonyms: Neratinib Impurity 35;2-((4-chloro-3-nitrophenoxy)methyl)pyridine;2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine;Pyridine, 2-[(2-chloro-4-nitrophenoxy)methyl]-;3-Chloro-4-(2-pyridinylmethoxy)-1-nitrobenzene
CBNumber: CB4855383
Molecular Formula: C12H9ClN2O3
Formula Weight: 264.66
MOL File: 179687-79-7.mol

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2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Property

storage temp.: Inert atmosphere,Room Temperature
Appearance: Light brown to brown Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M0296
Product name: 2-((2-chloro-4-nitrophenoxy)methyl)pyridine
Packaging: 250mg
Price: $104
Updated: 2021/12/16

AK Scientific

Product number: P372
Product name: 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
Packaging: 250mg
Price: $157
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC147747
Product name: 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
Packaging: 500mg
Price: $170
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC147747
Product name: 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
Packaging: 1g
Price: $260
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC147747
Product name: 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
Packaging: 2g
Price: $340
Updated: 2021/12/16

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2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Chemical Properties,Usage,Production

Uses

3-Chloro-4-(2-pyridylmethyloxy)nitrobenzene was used to synthesize aniline ''headgroups'' and incorporat them into an alkynyl thienopyrimidine series of EGFR and ErbB-?2 inhibitors.

Synthesis

619-08-9

6959-47-3

179687-79-7

General procedure for the synthesis of 2-((2-chloro-4-nitrophenoxy)methyl)pyridine from 2-chloro-4-nitrophenol and 2-chloromethylpyridine hydrochloride: 2-chloromethylpyridine hydrochloride (16.4 g, 0.1 mol) and potassium carbonate (K2CO3, 27.6 g, 0.2 mol) were suspended in N,N-dimethylformamide (DMF, 100 mL). stirred for 30 min at room temperature. Subsequently, 2-chloro-4-nitrophenol (17.4 g, 0.1 mol) and potassium iodide (KI, 0.83 g, 5 mol%) were added, and the reaction mixture was stirred for 12 hours at 60 °C. After completion of the reaction, the reaction mixture was diluted with water (400 mL), the resulting solid was collected by filtration, washed with water and dried to afford 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (26 g, 98% yield) as a white solid. The melting point of the product was 149.2-149.9 °C; mass spectra (MS-EI) m/z: 92, 229, 263 (M+).

References

[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 11, p. 3090 - 3104
[2] Patent: US2016/214964, 2016, A1. Location in patent: Paragraph 0138
[3] Patent: WO2005/10008, 2005, A1. Location in patent: Page/Page column 114-115
[4] Patent: WO2006/23843, 2006, A2. Location in patent: Page/Page column 64
[5] Patent: US2010/298297, 2010, A1. Location in patent: Page/Page column 14

2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Preparation Products And Raw materials

Raw materials

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2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Suppliers

China 74 India 1 United Kingdom 1 United States 6 Global 82

Alchem Pharmtech,Inc.

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View Lastest Price from 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine 179687-79-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-04-29

Career Henan Chemical Co

Product: 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine 179687-79-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-31

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179687-79-7