Methoxy-PEG-propionicacid-N-succinimidylester

Product Name: Methoxy-PEG-propionicacid-N-succinimidylester
CAS No.: 174569-25-6
Chemical Name: Methoxy-PEG-propionicacid-N-succinimidylester
Synonyms: m-PEG17-NHS ester;Methyl-PEGn-NHS (n=12,13,24);m-PEGn-NHS ester;mPEG₂₄-NHS;MPEGn-SPA 2K, 5K, 10K, 20K;Methoxy-PEG-NHS average M.W. 2000;alpha-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-omega-methoxypoly(oxy-1,2-ethanediyl)
CBNumber: CB51074968
Molecular Formula: (C2H4O)nC8H11NO5
Formula Weight: 0
MOL File: 174569-25-6.mol

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Methoxy-PEG-propionicacid-N-succinimidylester Property

storage temp.: -20°C
solubility: Soluble in DMSO, DCM, DMF
form: solid
color: white to off-white
α-end: methoxy
Ω-end: NHS ester
InChI: InChI=1S/C10H15NO6/c1-15-6-7-16-5-4-10(14)17-11-8(12)2-3-9(11)13/h2-7H2,1H3
InChIKey: IMSXKORGOVQCNT-UHFFFAOYSA-N
SMILES: O(N1C(CCC1=O)=O)C(=O)CCO{-}CC{+n}OC

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-21104
Product name: m-PEG12-NHSester
Purity: 98%
Packaging: 100mg
Price: $175
Updated: 2021/12/16

BroadPharm

Product number: BP-22250
Product name: m-PEG25-NHSester
Purity: 97%
Packaging: 100mg
Price: $220
Updated: 2021/12/16

Iris Biotech GmbH

Product number: PEG1880
Product name: MeO-dPEG(3)-NHS
Packaging: 100mg
Price: $270
Updated: 2021/12/16

BroadPharm

Product number: BP-24281
Product name: m-PEG17-NHSester
Purity: 98%
Packaging: 50mg
Price: $280
Updated: 2021/12/16

BroadPharm

Product number: BP-22248
Product name: m-PEG37-NHSester
Purity: 97%
Packaging: 100mg
Price: $320
Updated: 2021/12/16

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Methoxy-PEG-propionicacid-N-succinimidylester Chemical Properties,Usage,Production

Description

m-PEG12-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reagent type: chemical modification reagent
reactivity: amine reactive

IC 50

PEGs

References

[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

Methoxy-PEG-propionicacid-N-succinimidylester Preparation Products And Raw materials

Raw materials

Preparation Products

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Methoxy-PEG-propionicacid-N-succinimidylester Suppliers

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174569-25-6, Methoxy-PEG-propionicacid-N-succinimidylesterRelated Search:

DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) METHYL ISOCYANOACETATE Benzyl isocyanide Ferric acetylacetonate TERT-BUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE N-BUTYLISOCYANIDE PHENYLSELENOL Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) SALCOMINE Ethyl isocyanoacetate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Cupric acetylacetonate Aluminum acetylacetonate Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE

MPEGn-SPA 2K, 5K, 10K, 20K

alpha-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-omega-methoxypoly(oxy-1,2-ethanediyl)

Methyl-PEGn-NHS (n=12,13,24)

m-PEG17-NHS ester

m-PEGn-NHS ester

mPEG<sub>24</sub>-NHS

Methoxy-PEG-NHS average M.W. 2000

174569-25-6

C2H4OnC8H11NO5

C38H71NO20

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Polydispersed PEG