ChemicalBook > CAS DataBase List > Methyl 3-amino-2-thiophenecarboxylate

Methyl 3-amino-2-thiophenecarboxylate

Product Name
Methyl 3-amino-2-thiophenecarboxylate
CAS No.
22288-78-4
Chemical Name
Methyl 3-amino-2-thiophenecarboxylate
Synonyms
METHYL 3-AMINOTHIOPHENE-2-CARBOXYLATE;M3AT2C;AKOS 92421;ina-5545-2;Methyl3-am;AKOS B020093;Methyl 3-amino-2-;3-Amino-2-thenoate;RARECHEM AM UC 0123;Methyl 3-amino-2-thi
CBNumber
CB5123399
Molecular Formula
C6H7NO2S
Formula Weight
157.19
MOL File
22288-78-4.mol
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Methyl 3-amino-2-thiophenecarboxylate Property

Melting point:
62-64 °C (lit.)
Boiling point:
100-102 °C/0.1 mmHg (lit.)
Density 
1.274 (estimate)
refractive index 
1.5500 (estimate)
Flash point:
100-102°C/0.1mm
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Fine Crystalline Powder
pka
1.86±0.10(Predicted)
color 
Beige to beige-brown
Water Solubility 
Slightly soluble in water.
BRN 
1365614
InChI
InChI=1S/C6H7NO2S/c1-9-6(8)5-4(7)2-3-10-5/h2-3H,7H2,1H3
InChIKey
TWEQNZZOOFKOER-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)SC=CC=1N
CAS DataBase Reference
22288-78-4(CAS DataBase Reference)
EPA Substance Registry System
2-Thiophenecarboxylic acid, 3-amino-, methyl ester (22288-78-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36/37/39-22
WGK Germany 
3
RTECS 
XM8347500
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
232904
Product name
Methyl 3-amino-2-thiophenecarboxylate
Purity
99%
Packaging
10g
Price
$43.15
Updated
2025/07/31
Sigma-Aldrich
Product number
232904
Product name
Methyl 3-amino-2-thiophenecarboxylate
Purity
99%
Packaging
50g
Price
$208.05
Updated
2025/07/31
TCI Chemical
Product number
A1039
Product name
Methyl 3-Amino-2-thiophenecarboxylate
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
A1039
Product name
Methyl 3-Amino-2-thiophenecarboxylate
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$157
Updated
2025/07/31
TRC
Product number
A612075
Product name
3-Amino-2-methoxycarbonylthiophene
Packaging
100g
Price
$360
Updated
2021/12/16
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Methyl 3-amino-2-thiophenecarboxylate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Methyl 3-amino-2-thiophenecarboxylate was used in:

  • the synthesis of 4-nitro and 4-aminothienyl ureas
  • total synthesis of quinazolinocarboline alkaloids
  • preparation of thienopyrimidinone analogs

Uses

Methyl 3-amino-2-thiophenecarboxylate is the starting material for synthesising Belvarafenib. Belvarafenib is a small-molecule RAF dimer (type II) inhibitor with potential antitumour activity.

General Description

Methyl 3-amino-2-thiophenecarboxylate reacts with hydrazonoyl chlorides in the presence of triethylamine to yield corresponding N-arylamidrazones.

Methyl 3-amino-2-thiophenecarboxylate Preparation Products And Raw materials

Raw materials

Methyl thioglycolate 1.3-Dichloropropene Sodium methoxide solution Acrylonitrile

Preparation Products

2,4-DICHLOROTHIENO[3,2-D]PYRIMIDINE 3-(Acetylamino)thiophene-2-carboxylic acid 3-(1H-PYRROL-1-YL)THIOPHENE-2-CARBOXYLIC ACID 2,4-Dichlorothieno[3,2-d]pyrimidine Methyl 3-aminosulfonylthiophene-2-carboxylate METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE 3-CHLOROTHIOPHENE-2-CARBOXAMIDE METHYL 3-[(2-BROMOACETYL)AMINO]THIOPHENE-2-CARBOXYLATE 2,4-DIHYDROXYTHIENO[3,2-D]PYRIMIDINE
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View Lastest Price from Methyl 3-amino-2-thiophenecarboxylate manufacturers

Shandong Vital Biotechnology Co., Ltd.
Product
Methyl3-amino-2-thiophenecarboxylate 22288-78-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100tons
Release date
2025-11-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Methyl 3-amino-2-thiophenecarboxylate 22288-78-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-25
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Methyl 3-amino-2-thiophene carboxylate 22288-78-4
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-26

22288-78-4, Methyl 3-amino-2-thiophenecarboxylate Related Search:

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  • Methyl 3-aminothiophene-2-carboxylateQ: What is Methyl 3-aminothiophene-2-carboxylate Q: What is the CAS Number of Methyl 3-aminothiophene-2-carboxylate Q: What is the storage condition of Methyl 3-aminothiophene-2-carboxylate Q: What are the applications of Methyl 3-aminothiophene-2-carboxylate
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