ChemicalBook > CAS DataBase List > Nedaplatin

Nedaplatin

Product Name
Nedaplatin
CAS No.
95734-82-0
Chemical Name
Nedaplatin
Synonyms
254-s;Aqupla;Nedaplait;NEDAPLATIN;NSC 375101D;Nedaplatin, >=99%;Nedaplatin USP/EP/BP;Nedaplatin (NSC 375101D);cis-diammine(glycolato)platinum(ii);(glycolato-o,o')diammineplatinum(ii)
CBNumber
CB5127746
Molecular Formula
C2H6N2O3Pt
Formula Weight
301.17
MOL File
95734-82-0.mol
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Nedaplatin Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29001
Product name
Nedaplatin
Packaging
25mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
29001
Product name
Nedaplatin
Packaging
250mg
Price
$671
Updated
2024/03/01
Cayman Chemical
Product number
29001
Product name
Nedaplatin
Packaging
50mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
29001
Product name
Nedaplatin
Packaging
100mg
Price
$287
Updated
2024/03/01
TRC
Product number
N388803
Product name
Nedaplatin
Packaging
10mg
Price
$130
Updated
2021/12/16
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Nedaplatin Chemical Properties,Usage,Production

Description

Nedaplatin, a novel second generation platinum complex, was marketed in Japan for the treatment of a variety of cancers including: head and neck, small-cell and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder, and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more active than cisplatin against several solid tumors while sharing less nephro- and gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by nedaplatin allows its use in patients with deteriorated renal function.

Originator

Shionogi (Japan)

Uses

anticancer

Uses

Nedaplatin is a platinum complex that has potent antineoplatic activity.

brand name

Aqupla

Pharmaceutical Applications

Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin. The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleaving groups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatin has been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular, ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effect is myelosuppression.

Nedaplatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Nedaplatin Suppliers

China 185 Europe 2 Germany 1 India 1 United Kingdom 6 United States 24 Global 219
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View Lastest Price from Nedaplatin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Nedaplatin 95734-82-0
Price
US $0.00/g
Min. Order
1g
Purity
98%-102%
Supply Ability
100g
Release date
2022-12-29
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nedaplatin 95734-82-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nedaplatin 95734-82-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

95734-82-0, NedaplatinRelated Search:

Platinum (II), diammineoxalato-, cis- Adriamycin Gemcitabine Cytarabine Fluorescein Sodium Dexrazoxane Zoledronic acid Carboplatin PHT-427 Dasatinib CHIR-99021 Sofosbuvir BEZ235 (NVP-BEZ235, Dactolisib) Cisplatin Miboplatin Oxaliplatin Nedaplatin NEDAPLATIN

  • (glycolato-o,o')diammineplatinum(ii)
  • cis-diammine(glycolato)platinum(ii)
  • NEDAPLATIN
  • 254-s
  • Aqupla
  • cis-diamine-glycolate-O,O'-platinum(II)
  • o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu
  • Nedaplait
  • o(sup 2))- diammine(hydroxyacetato(2-)-o(sup 1 (sp-4-3)-platinu (glycolato-o,o')diammineplatinum(ii) 254-s cis-diammine(glycolato)platinum(ii) nedaplatin nsc 375101d
  • 2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one
  • PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-, (SP-4-3)-
  • (SP-4-3)-diammine[2-(hydroxy-κO)acetato(2-)-κO]-platinum
  • Nedaplatin, >=99%
  • cis-Diammine(glycolato(2-)O,O')platinum
  • Cis-diammine-glycoloato-O,O'-platinum(II)
  • platinum(2+) azanide- hydroxyacetic acid(1:2:1)
  • NSC 375101D
  • Nedaplatin USP/EP/BP
  • Nedaplatin (NSC 375101D)
  • 95734-82-0
  • C2H4N2O3Pt
  • C2H8N2O3Pt
  • C2H2O3Pt2H3N
  • Inhibitors
  • Anticancer
  • Anticancer Platinum Agent