Nedaplatin
- Product Name
- Nedaplatin
- CAS No.
- 95734-82-0
- Chemical Name
- Nedaplatin
- Synonyms
- 254-s;Aqupla;Nedaplait;NEDAPLATIN;NSC 375101D;Nedaplatin, >=99%;Nedaplatin USP/EP/BP;Nedaplatin (NSC 375101D);cis-diammine(glycolato)platinum(ii);(glycolato-o,o')diammineplatinum(ii)
- CBNumber
- CB5127746
- Molecular Formula
- C2H6N2O3Pt
- Formula Weight
- 301.17
- MOL File
- 95734-82-0.mol
Nedaplatin Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29001
- Product name
- Nedaplatin
- Packaging
- 25mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 29001
- Product name
- Nedaplatin
- Packaging
- 250mg
- Price
- $671
- Updated
- 2024/03/01
- Product number
- 29001
- Product name
- Nedaplatin
- Packaging
- 50mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 29001
- Product name
- Nedaplatin
- Packaging
- 100mg
- Price
- $287
- Updated
- 2024/03/01
- Product number
- N388803
- Product name
- Nedaplatin
- Packaging
- 10mg
- Price
- $130
- Updated
- 2021/12/16
Nedaplatin Chemical Properties,Usage,Production
Description
Nedaplatin, a novel second generation platinum complex, was marketed in Japan for the treatment of a variety of cancers including: head and neck, small-cell and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder, and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more active than cisplatin against several solid tumors while sharing less nephro- and gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by nedaplatin allows its use in patients with deteriorated renal function.
Originator
Shionogi (Japan)
Uses
anticancer
Uses
Nedaplatin is a platinum complex that has potent antineoplatic activity.
brand name
Aqupla
Pharmaceutical Applications
Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin. The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleaving groups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatin has been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular, ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effect is myelosuppression.
Nedaplatin Preparation Products And Raw materials
Raw materials
Preparation Products
Nedaplatin Suppliers
View Lastest Price from Nedaplatin manufacturers
- Product
- Nedaplatin 95734-82-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%-102%
- Supply Ability
- 100g
- Release date
- 2022-12-29
- Product
- Nedaplatin 95734-82-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Nedaplatin 95734-82-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08