abciximab

Product Name: abciximab
CAS No.: 143653-53-6
Chemical Name: abciximab
Synonyms: Reopro;Rheopro;CentoRx;c7E3 Fab;Abcixifiban;Unii-X85G7936gv;Research Grade Abciximab(DHC33301);Immunoglobulin G1, (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain
CBNumber: CB51319184
Formula Weight: 0
MOL File: Mol file

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abciximab Property

storage temp.: Store at -80°C
form: Liquid
color: Colorless to light yellow

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Safety

Hazardous Substances Data: 143653-53-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: ATB0010203
Product name: ABCIXIMAB
Purity: 98.00%
Packaging: 5MG
Price: $498
Updated: 2021/12/16

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abciximab Chemical Properties,Usage,Production

Uses

Monoclonal antibody (antithrombotic).

brand name

ReoPro (Lilly).

Clinical Use

Antiplatelet agent:
Prevention of ischaemic cardiac complications in patients undergoing percutaneous coronary intervention
Short-term prevention of myocardial infarction in patients with unstable angina not responding to treatment or awaiting percutaneous coronary intervention.

Enzyme inhibitor

This antithrombotic (MW = 47455 g/mol; CAS 143653-53-6; also known as Reopro?) consists of an immunoglobulin G1 Fab fragment from a chimeric human-murine monoclonal antibody directed against the human platelet glycoprotein IIb/IIIa receptor. Abciximab also facilitates the dispersal of newly formed platelet aggregates in vitro, by partially displacing fibrinogen from activated GPIIb/IIIareceptors. In vivo, abciximab may destabilize coronary thrombi by preventing aggregate formation and dispersing mural thrombi. Target(s): coagulation factor Xa, in presence of heparin; glycoprotein IIb/IIIa receptor.

Drug interactions

Potentially hazardous interactions with other drugs
Heparin, anticoagulants, antiplatelets and thrombolytics: increased risk of bleeding.

Metabolism

Following IV administration, abciximab rapidly binds to the platelet GPIIb/IIIa receptors, and remains in the circulation for 15 days or more in a platelet-bound state. Metabolism is via proteolytic cleavage

abciximab Preparation Products And Raw materials

Raw materials

Preparation Products

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abciximab Suppliers

China 16 United States 3 Global 19

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143653-53-6, abciximabRelated Search:

Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Tosylmethyl isocyanide SALCOMINE PHENYLSELENOL TERT-BUTYL ISOCYANIDE Aluminum acetylacetonate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE Ethyl isocyanoacetate Cupric acetylacetonate METHYL ISOCYANOACETATE Benzyl isocyanide Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

Reopro

Unii-X85G7936gv

CentoRx

Immunoglobulin G1, (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain

Rheopro

Research Grade Abciximab(DHC33301)

Abcixifiban

c7E3 Fab

143653-53-6