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berberrubine

Product Name
berberrubine
CAS No.
15401-69-1
Chemical Name
berberrubine
Synonyms
Berberrubine chloride;Chileninone;Beroline;grubbiness;Nerberrubine;berberrubine;Beroline chloride;9-Berberoline chloride;Berberubine chloride form;Berberrubine/Berberrubine chloride
CBNumber
CB51356211
Molecular Formula
C19H16ClNO4
Formula Weight
357.78764
MOL File
15401-69-1.mol
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berberrubine Property

Melting point:
245℃ (DEC.)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Dark Yellow
Stability:
Hygroscopic
InChI
InChI=1S/C19H15NO4.ClH/c1-22-16-3-2-11-6-15-13-8-18-17(23-10-24-18)7-12(13)4-5-20(15)9-14(11)19(16)21;/h2-3,6-9H,4-5,10H2,1H3;1H
InChIKey
GYFSYEVKFOOLFZ-UHFFFAOYSA-N
SMILES
[Cl-].O1C([H])([H])OC2=C1C([H])=C1C(=C2[H])C2C([H])=C3C([H])=C([H])C(=C(C3=C([H])[N+]=2C([H])([H])C1([H])[H])O[H])OC([H])([H])[H]
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B200095
Product name
BerberrubineChloride
Packaging
1mg
Price
$50
Updated
2021/12/16
TRC
Product number
B200095
Product name
BerberrubineChloride
Packaging
2.5mg
Price
$100
Updated
2021/12/16
TRC
Product number
B200095
Product name
BerberrubineChloride
Packaging
5mg
Price
$150
Updated
2021/12/16
Usbiological
Product number
300000
Product name
Berberrubine
Packaging
10mg
Price
$390
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB74002
Product name
Berberrubine chloride
Packaging
10mg
Price
$120
Updated
2021/12/16
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berberrubine Chemical Properties,Usage,Production

Chemical Properties

Soluble in acidic solution, insoluble in petroleum ether, chloroform and other solvents. Derived from the roots of Thalictrum polygamun Muhl.

Uses

Berberrubine Chloride is a novel alkaloid with novel nitric-oxide donating activity. Antitumor and an antimicrobial agent.

Definition

ChEBI: Berberrubine is an alkaloid.

in vivo

Berberrubine (oral administration; 10-20 mg/kg; 7 days) has a beneficial effect in a mouse colitis model[3].

Animal Model:DSS (HY-116282) treated male Balb/c mice aged 6 weeks old[3]
Dosage:10 and 20 mg/kg
Administration:Oral administration (p.o.); 7 days
Result:Significantly reduced the disease activity index (DAI) with prolonged colon length and increased bodyweight at dose of 20 mg/kg.
Significantly ameliorated the DSS-induced colonic pathological alternations and decreased histological scores.
Markedly attenuated colonic inflammation by alleviating inflammatory cell infiltration and inhibiting myeloperoxidase (MPO) and cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10) productions in DSS mice.
Substantially upregulated the expression of tight junction proteins (zonula occludens-1, zonula occludens-2, claudin-1, occludin) and mRNA expression of mucins (mucin-1 and mucin-2), and decreased the Bax/Bcl-2 ratio.

berberrubine Preparation Products And Raw materials

Raw materials

Preparation Products

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berberrubine Suppliers

China 207 France 1 India 1 United Kingdom 1 United States 10 Global 220
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View Lastest Price from berberrubine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
berberrubine 15401-69-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Shanghai Standard Technology Co., Ltd.
Product
Berberrubine 15401-69-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥90%(HPLC)
Supply Ability
10 g
Release date
2019-11-27
Baoji Guokang Healthchem co.,ltd
Product
berberrubine 15401-69-1
Price
US $95.00/mg
Min. Order
20mg
Purity
99%
Supply Ability
10kg
Release date
2021-06-08

15401-69-1, berberrubineRelated Search:

Citric acid Schisandrin A Tetrahydroberberine Hydroxysafflor yellow A BERBAMINE DIHYDROCHLORIDE BERBAMINE BERBERINE ACID SULFATE Salicylic acid Resveratrol (+)-Camptothecin Rutin Coptisine chloride Glycyrrhizic acid epiberberine Potassium iodide Berberine hydrochloride BERBERINE CHLORIDE Berberine

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  • 9-Berberoline chloride
  • 9-Demethoxy-9-hydroxyberberinium chloride
  • Berberrubine chloride
  • Beroline chloride
  • berberrubine
  • Chileninone
  • Nerberrubine
  • 9-Hydroxy-10-methoxy-5,6-dihydro-[1,3]dioxolo-[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chlo
  • Berberubine chloride form
  • Beroline
  • BERBERRUBINE,HYDROCHLORIDE,DIHYDRATE
  • 9-hydroxy-10-methoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride
  • grubbiness
  • 10-methoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium-9-olate
  • Berberrubine/Berberrubine chloride
  • Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9-hydroxy-10-methoxy-, chloride (1:1)
  • 9-Berberoline Chloride|||Beroline|||Beroline Chloride|||Berberrubine|||9-Berberoline
  • Berberrubine chloride, 10 mM in DMSO
  • 15401-69-1
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract