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Nisoldipine

Product Name
Nisoldipine
CAS No.
63675-72-9
Chemical Name
Nisoldipine
Synonyms
Sular;NisoL;Syseor;SYSCOR;Nisocor;NORVASC;Nikameal;ZADIPINA;BAYMYCARD;Nisomynard
CBNumber
CB5147166
Molecular Formula
C20H24N2O6
Formula Weight
388.41
MOL File
63675-72-9.mol
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Nisoldipine Property

Melting point:
147-148°C
Boiling point:
503.3±50.0 °C(Predicted)
Density 
1.205±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: >10mg/mL
form 
powder
pka
2.67±0.70(Predicted)
color 
yellow
Merck 
14,6565
InChIKey
VKQFCGNPDRICFG-UHFFFAOYSA-N
CAS DataBase Reference
63675-72-9(CAS DataBase Reference)
NIST Chemistry Reference
Nisoldipine(63675-72-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
RTECS 
US7975600
HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N0165
Product name
Nisoldipine
Purity
≥98% (HPLC)
Packaging
10mg
Price
$84.1
Updated
2024/03/01
Sigma-Aldrich
Product number
N0165
Product name
Nisoldipine
Purity
≥98% (HPLC)
Packaging
50mg
Price
$351
Updated
2024/03/01
TCI Chemical
Product number
N0900
Product name
Nisoldipine
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$91
Updated
2024/03/01
TCI Chemical
Product number
N0900
Product name
Nisoldipine
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$227
Updated
2024/03/01
Alfa Aesar
Product number
H37972
Product name
Nisoldipine
Purity
98%
Packaging
1g
Price
$119
Updated
2023/06/20
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Nisoldipine Chemical Properties,Usage,Production

Description

Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.

Chemical Properties

Nisoldipine D4 is Light Tan Crystals

Originator

Bayer AG (Germany)

Uses

Dihydropyridine calcium channel blocker. Antihypertensive and antianginal

Uses

urease inhibitor

Uses

Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.

Manufacturing Process

Boiling a solution of 12.7 g of 2'-nitrobenzylideneacetoacetic acid methyl ester and 7.1 g of β-amino-crotonic acid isopropyl ester in 50 ml of methanol for 10 hours yielded 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid 3-methyl ester-5-isopropyl ester of melting point 174°C (from ethanol). Yield 48% of theory.

brand name

Sular (Sciele);Baymycard.

Therapeutic Function

Coronary vasodilator

General Description

In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.

Biochem/physiol Actions

L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.

Nisoldipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate 2-Nitrobenzaldehyde Isobutyl acetoacetate

Preparation Products

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View Lastest Price from Nisoldipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Nisoldipine 63675-72-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2021-07-01
Hebei Weibang Biotechnology Co., Ltd
Product
Nisoldipine 63675-72-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06
Hebei Mojin Biotechnology Co., Ltd
Product
Nisoldipine 63675-72-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-05

63675-72-9, NisoldipineRelated Search:

Dimethyl sulfate Dimethyl carbonate 2,5-PYRIDINEDICARBOXYLIC ACID 4-Nitrobenzoic acid ETHANE Dihydromyrcenol Quinolinic acid N,N-Dimethylformamide Dimethyl sebacate 2,6-Lutidine Dimethyl fumarate Dimethyl sulfide Dimethyl sulfoxide Dimethyl ether Nitrendipine Nicardipine Nimodipine Doxazosin

  • 3-Isobutyl 5-Methyl 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid-3-methyl 5-(2-methylpropyl) ester
  • (±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
  • 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isobutyl ester
  • Nikameal
  • Ninobarucin
  • Nisomynard
  • 3-Methyl 5-(2-Methylpropyl) (4R)-2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Nisoldipine (Sular)
  • 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)-, 3-Methyl 5-(2-Methylpropyl)ester
  • Nisoldipine-d4
  • methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Nisoldipine, >=99%
  • Nisoldipine(BAY-k 5552
  • 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester
  • 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-met
  • hyl2-methylpropylester
  • BAYMYCARD
  • BAY K 5552
  • ZADIPINA
  • ISOBUTYL METHYL (- 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
  • Baymycard, Norvasc, Syscor, Zadipina, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-methylpropyl Ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester (9CI)
  • Nisocor
  • Sular
  • Syseor
  • 2，6-Dimethyl-4-(2-nitmphenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-methylpropyl ester
  • NORVASC
  • NISOLDIPINE
  • NISOLIDIPINE
  • SYSCOR
  • Nisoldipin
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2-METHYLPROPYL ESTER
  • Nisoldipine-d6
  • Nisoldipine&gt
  • Nisoldipine Nisoldipine
  • NisoL
  • 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Isobutyl Methyl Ester
  • Nisoldipine USP/EP/BP
  • NisoldipineQ: What is Nisoldipine Q: What is the CAS Number of Nisoldipine Q: What is the storage condition of Nisoldipine Q: What are the applications of Nisoldipine
  • hexakis(dihydrogen phosphate)
  • 63675-72-9
  • C20H18N2O6D6
  • C20H24N2O6
  • Calcium channel
  • Cardiovascular APIs
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