STEM CELL FACTOR, HUMAN
Description Background- Product Name
- STEM CELL FACTOR, HUMAN
- CAS No.
- 133352-98-4
- Chemical Name
- STEM CELL FACTOR, HUMAN
- Synonyms
- RHSCF;HUMAN SF;HUMAN SCF;HUMAN MGF;SCF, HUMAN;REC SCF (HUMAN);C-KIT LIGAND HUMAN;HUMAN STEEL FACTOR;HUMAN C-KIT LIGAND;RECOMBINANT HUMAN SCF
- CBNumber
- CB5149605
- Formula Weight
- 0
- MOL File
- Mol file
STEM CELL FACTOR, HUMAN Property
- storage temp.
- −20°C
- form
- powder
- color
- white
- biological source
- human
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- SRP3151
- Product name
- SCF human
- Purity
- Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 10μg
- Price
- $459
- Updated
- 2025/07/31
- Product number
- S7901
- Product name
- Stem Cell Factor human
- Purity
- SCF, recombinant, expressed in E. coli, powder, suitable for cell culture
- Packaging
- 10μg
- Price
- $492
- Updated
- 2025/07/31
- Product number
- S7901
- Product name
- Stem Cell Factor human
- Purity
- SCF, recombinant, expressed in E. coli, powder, suitable for cell culture
- Packaging
- 50μg
- Price
- $726
- Updated
- 2025/07/31
- Product number
- H8416
- Product name
- Stem Cell Factor human
- Purity
- SCF, recombinant, expressed in HEK 293 cells, suitable for cell culture
- Packaging
- 10μg
- Price
- $423
- Updated
- 2025/07/31
- Product number
- H8416
- Product name
- Stem Cell Factor human
- Purity
- SCF, recombinant, expressed in HEK 293 cells, suitable for cell culture
- Packaging
- 5x10μg
- Price
- $1650
- Updated
- 2023/01/07
STEM CELL FACTOR, HUMAN Chemical Properties,Usage,Production
General Description
The KITLG (KIT ligand) gene is mapped to human chromosome 12q21.32.
Biochem/physiol Actions
Stem Cell Factor (SCF), also known as c-Kit ligand (KL), steel factor (SLF) and mast cell growth factor (MGF), is a 30 kDa glycoprotein with broad activities on various tissues, including hematopoietic cells, pigment cells, and primordial germ cells. SCF is secreted by endothelial cells, fibroblasts, and bone marrow stromal cells as a membrane-bound form which may be cleaved to release the soluble form. Both forms are active in promoting colony formation from murine bone marrow cells, but membrane-bound SCF is more effective in promoting hematopoieses in vivo, suggesting a role in cellular interactions between hematopoietic and stromal cells. The soluble is thought to exist in solution as a noncovalently linked dimer. SCF is structurally related to M-CSF (CSF-1) and Flt-3/Flk-2 Ligand (FL) with all three sharing a similar size, existence of transmembrane and soluble forms, four conserved cysteines, and alternative splicing exon locations, but they share little sequence homology. SCF alone is a modest colony stimulating factor. However, in the presence of other cytokines such as EPO, TPO, GM-CSF, G-CSF, M-CSF, IL-3, and IL-7, SCF is a potent costimulant that works synergistically to increase the size of myeloid, erythroid or lymphoid lineage colonies without influencing the lineage differentiation of the progenitors.
Description
Stem Cell Factor Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids and having a molecular mass of 18409 Dalton.
The SCF is purified by proprietary chromatographic techniques.
Background
Stem cell factor / KIT ligand (SCF) is a cytokine which binds CD117(c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases. SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E (burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid).
STEM CELL FACTOR, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
STEM CELL FACTOR, HUMAN Suppliers
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