ChemicalBook > CAS DataBase List > Isopropyl 3-aminocrotonate

Isopropyl 3-aminocrotonate

Product Name
Isopropyl 3-aminocrotonate
CAS No.
14205-46-0
Chemical Name
Isopropyl 3-aminocrotonate
Synonyms
3-AIE;Nitrendipine Impurity J;Isopropyl aminocrotonate;Nitrendipine Impurity 10;Isopropy1-3-aminocrotomate;ISOPROPYL 3-AMINOCROTONATE;Intermediate Of Nimodipine;Isopropyl b-aminocrotonate;isopropylbeta-aminocrotonate;Isopropyl3-amino-2-butenoate
CBNumber
CB5194645
Molecular Formula
C7H13NO2
Formula Weight
143.18
MOL File
14205-46-0.mol
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Isopropyl 3-aminocrotonate Property

Melting point:
19-23°C
Boiling point:
80°C/1mmHg(lit.)
Density 
0.987±0.06 g/cm3(Predicted)
refractive index 
1.4870 to 1.4910
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform, Ethyl Acetate, Methanol
form 
Colourless Liquid
pka
5.36±0.70(Predicted)
color 
Colorless to Light yellow
InChI
InChI=1S/C7H13NO2/c1-5(2)10-7(9)4-6(3)8/h4-5H,8H2,1-3H3
InChIKey
YCKAGGHNUHZKCL-UHFFFAOYSA-N
SMILES
C(OC(C)C)(=O)C=C(N)C
CAS DataBase Reference
14205-46-0(CAS DataBase Reference)
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Safety

RTECS 
EM9095000
HazardClass 
IRRITANT
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
I0884
Product name
Isopropyl 3-Aminocrotonate
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
I0884
Product name
Isopropyl 3-Aminocrotonate
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$111
Updated
2025/07/31
Matrix Scientific
Product number
064718
Product name
Isopropyl (2Z)-3-aminobut-2-enoate
Packaging
500mg
Price
$119
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0000380
Product name
ISOPROPYL 3-AMINOCROTONATE
Purity
95.00%
Packaging
5G
Price
$121.8
Updated
2021/12/16
AK Scientific
Product number
P785
Product name
Isopropyl 3-Aminocrotonate
Packaging
500g
Price
$150
Updated
2021/12/16
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Isopropyl 3-aminocrotonate Chemical Properties,Usage,Production

Chemical Properties

Colourless Liquid

Uses

Isopropyl 3-Aminocrotonate (cas# 14205-46-0) is a compound useful in organic synthesis.

Hazard

Moderately toxic by ingestion. Low toxicity by inhalation. A mild skin and eye irritant.

Synthesis

542-08-5

14205-46-0

The general procedure for the synthesis of isopropyl 3-amino-2-butenoate from isopropyl acetoacetate was as follows: 2.0 g (~20.83 mmol) of isopropyl acetoacetate was accurately weighed and dissolved in 15 mL of anhydrous ethanol. Subsequently, 1.6 g of ammonium acetate was added and the reaction mixture was heated to reflux at 90°C in an oil bath. The reaction progress was monitored by thin layer chromatography (TLC). After 24 hours of reaction, the heating was stopped and the reaction mixture was evaporated to dryness at low temperature. Finally, the reaction solution was distilled under reduced pressure to afford the target compound isopropyl 3-amino-2-butenoate (compound Sf) in 100% yield.

References

[1] Patent: CN102464608, 2016, B. Location in patent: Paragraph 0153; 0154
[2] Patent: CN108101798, 2018, A. Location in patent: Paragraph 0022; 0024; 0026; 0028; 0030-0032; 0034; 0036
[3] Patent: CN105461691, 2016, A. Location in patent: Paragraph 0016
[4] Chemical and Pharmaceutical Bulletin, 1979, vol. 27, # 6, p. 1426 - 1440
[5] Chemical and Pharmaceutical Bulletin, 1989, vol. 37, # 8, p. 2117 - 2121

Isopropyl 3-aminocrotonate Preparation Products And Raw materials

Raw materials

Isopropyl acetoacetate Ammonia

Preparation Products

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Isopropyl 3-aminocrotonate Suppliers

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View Lastest Price from Isopropyl 3-aminocrotonate manufacturers

Career Henan Chemical Co
Product
Isopropyl 3-aminocrotonate 14205-46-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20KG
Release date
2018-08-07

14205-46-0, Isopropyl 3-aminocrotonateRelated Search:

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  • ISOPROPYL 3-AMINOCROTONATE
  • isopropylbeta-aminocrotonate
  • 3-Aminobutenoic acid isopropylester
  • BETA-AMINOCROTONIC ACID ISOPROPYL ESTER
  • ISOPROPYL 3-AMINOCROTONATE(3-AMINOCROTONIC ACID ISOPROPYL ESTER)
  • Isopropy1-3-aminocrotomate
  • 3-amino-2-butenoic acid 1-methylethyl ester
  • Isopropyl aminocrotonate
  • Isopropyl (2Z)-3-aminobut-2-enoate
  • Isopropyl 3-AMinocrotonate, 97+%
  • 2-Butenoic acid, 3-amino-, 1-methylethyl ester
  • NiModipine interMediate product
  • Isopropyl 3-aMinobut-2-enoate
  • 3-Aminocrotonic acid isopropyl ester
  • 3-AMINO-BUT-2-ENOIC ACID ISOPROPYL ESTER
  • 1-methylethyl3-amino-2-butenoate
  • 1-methylethyl3-aminocrotonate
  • 3-amino-2-butenoicaci1-methylethylester
  • 3-amino-crotonicaciisopropylester
  • Isopropyl3-amino-2-butenoate
  • Nitrendipine Impurity J
  • 3-amino-2-butenoic acid propan-2-yl ester
  • Isopropyl3-Aminocrotonate&gt
  • 3-amino-crotonic acid isopropyl
  • Isopropyl 3-aminocrotonate ISO 9001：2015 REACH
  • Nitrendipine Impurity 10
  • 2-Butenoic acid, 3-amino-, 1-methylethyl ester (9CI, ACI)
  • 3-amino-2-Butenoic acid 1-methylethyl ester (9CI ACI)
  • 3-Amino-but-2-enoic acid 1-methylethyl ester
  • Intermediate Of Nimodipine
  • Isopropyl b-aminocrotonate
  • 3-AIE
  • 14205-46-0
  • Heterocyclic Acids
  • Miscellaneous Reagents