Isopropyl 3-aminocrotonate
- Product Name
- Isopropyl 3-aminocrotonate
- CAS No.
- 14205-46-0
- Chemical Name
- Isopropyl 3-aminocrotonate
- Synonyms
- 3-AIE;Nitrendipine Impurity J;Isopropyl aminocrotonate;Nitrendipine Impurity 10;Isopropy1-3-aminocrotomate;ISOPROPYL 3-AMINOCROTONATE;Intermediate Of Nimodipine;Isopropyl b-aminocrotonate;isopropylbeta-aminocrotonate;Isopropyl3-amino-2-butenoate
- CBNumber
- CB5194645
- Molecular Formula
- C7H13NO2
- Formula Weight
- 143.18
- MOL File
- 14205-46-0.mol
Isopropyl 3-aminocrotonate Property
- Melting point:
- 19-23°C
- Boiling point:
- 80°C/1mmHg(lit.)
- Density
- 0.987±0.06 g/cm3(Predicted)
- refractive index
- 1.4870 to 1.4910
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform, Ethyl Acetate, Methanol
- form
- Colourless Liquid
- pka
- 5.36±0.70(Predicted)
- color
- Colorless to Light yellow
- InChI
- InChI=1S/C7H13NO2/c1-5(2)10-7(9)4-6(3)8/h4-5H,8H2,1-3H3
- InChIKey
- YCKAGGHNUHZKCL-UHFFFAOYSA-N
- SMILES
- C(OC(C)C)(=O)C=C(N)C
- CAS DataBase Reference
- 14205-46-0(CAS DataBase Reference)
Safety
- RTECS
- EM9095000
- HazardClass
- IRRITANT
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I0884
- Product name
- Isopropyl 3-Aminocrotonate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- I0884
- Product name
- Isopropyl 3-Aminocrotonate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- 064718
- Product name
- Isopropyl (2Z)-3-aminobut-2-enoate
- Packaging
- 500mg
- Price
- $119
- Updated
- 2021/12/16
- Product number
- APN0000380
- Product name
- ISOPROPYL 3-AMINOCROTONATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $121.8
- Updated
- 2021/12/16
- Product number
- P785
- Product name
- Isopropyl 3-Aminocrotonate
- Packaging
- 500g
- Price
- $150
- Updated
- 2021/12/16
Isopropyl 3-aminocrotonate Chemical Properties,Usage,Production
Chemical Properties
Colourless Liquid
Uses
Isopropyl 3-Aminocrotonate (cas# 14205-46-0) is a compound useful in organic synthesis.
Hazard
Moderately toxic by ingestion. Low toxicity by inhalation. A mild skin and eye irritant.
Synthesis
542-08-5
14205-46-0
The general procedure for the synthesis of isopropyl 3-amino-2-butenoate from isopropyl acetoacetate was as follows: 2.0 g (~20.83 mmol) of isopropyl acetoacetate was accurately weighed and dissolved in 15 mL of anhydrous ethanol. Subsequently, 1.6 g of ammonium acetate was added and the reaction mixture was heated to reflux at 90°C in an oil bath. The reaction progress was monitored by thin layer chromatography (TLC). After 24 hours of reaction, the heating was stopped and the reaction mixture was evaporated to dryness at low temperature. Finally, the reaction solution was distilled under reduced pressure to afford the target compound isopropyl 3-amino-2-butenoate (compound Sf) in 100% yield.
References
[1] Patent: CN102464608, 2016, B. Location in patent: Paragraph 0153; 0154
[2] Patent: CN108101798, 2018, A. Location in patent: Paragraph 0022; 0024; 0026; 0028; 0030-0032; 0034; 0036
[3] Patent: CN105461691, 2016, A. Location in patent: Paragraph 0016
[4] Chemical and Pharmaceutical Bulletin, 1979, vol. 27, # 6, p. 1426 - 1440
[5] Chemical and Pharmaceutical Bulletin, 1989, vol. 37, # 8, p. 2117 - 2121
Isopropyl 3-aminocrotonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isopropyl 3-aminocrotonate manufacturers
- Product
- Isopropyl 3-aminocrotonate 14205-46-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20KG
- Release date
- 2018-08-07